Bioactive Diterpenoids from the Leaves of <i>Callicarpa macrophylla</i>

Xu, Jing; Sun, Yihang; Wang, Meicheng; Ren, Quanhui; Shen, Li; Wang, Hao; Sun, Xiaocong; Jin, Da-Qing; Sun, Hongwei; Ohizumi, Yasushi; Guo, Yuanqiang

doi:10.1021/acs.jnatprod.5b00018

Cited by 47 publications

(35 citation statements)

References 44 publications

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“…The genus of Callicarpa consists about 140 species that are distributed mostly in Oceania and east and southeast Asia including India, Myanmar, Thailand, and Vietnam [1][2][3], of which, several species such as Callicarpa candicans, C. americana L., C. japonica, C. macrophylla, and C. longissimi are highly valued for their essential oils, which are rich in terpenoids, phenylethanoids, volatile oils, lignans, and flavonoids. These classes have been known for a wide range of biological activities including antimicrobial, analgesic, antipyretic, anti-inflammatory, and anti-infection [2,[4][5][6][7]. C. candicans (Burm.…”

Section: Introductionmentioning

confidence: 99%

Optimization of Microwave-Assisted Extraction Process of Callicarpa candicans (Burm. f.) Hochr Essential Oil and Its Inhibitory Properties against Some Bacteria and Cancer Cell Lines

et al. 2020

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Callicarpa candicans (Burm. f.) Hochr. (Callicarpa cana L.) is a medicinal plant that is distributed mainly in the tropics and subtropics of Asia and finds a wide range of uses in traditional medicine. In this study, we attempted and optimized the microwave-assisted hydro-distillation (MAHD) process to obtain essential oil from the leaves of C. candicans. In addition, the obtained oil was analyzed for volatile composition by gas chromatography–mass spectrometry (GC-MS) and assayed for bioactivity against several bacteria and cancer cell lines. To optimize the extraction process, response surface methodology (RSM) in combination with central composite design (CCD) was adopted. Experimental design and optimization were carried out with respect to three experimental factors including the ratio of water to raw material, extraction time, and microwave power. The optimal extraction conditions were obtained as follows: water to raw material ratio of 6/1 (v/w), extraction time 42 min, and microwave power 440 W. Composition determination of the obtained C. candicans essential oil indicated the presence of predominant components including caryophyllene <b-> (10.45%), cadinene <d-> (10.28%), gurjunene <a-> (8.95%), muurolene <g-> (8.92%), selinene <a-> (7.06%), selinene <b-> (5.59%), and copaene <a-> (5.40%). In comparison with the essential oils obtained via traditional hydro-distillation method, the essential oil extracted by MAHD exhibited superior anti-proliferative activity on all tested cancer cell lines. Current results imply that the MAHD is capable of recovering biologically-active natural products of greater quantity than that recovered by the conventional distillation.

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Section: Introductionmentioning

confidence: 99%

Optimization of Microwave-Assisted Extraction Process of Callicarpa candicans (Burm. f.) Hochr Essential Oil and Its Inhibitory Properties against Some Bacteria and Cancer Cell Lines

et al. 2020

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“…The absolute configurations of 1 and 2 were elucidated by electronic circular dichroism (ECD) calculations . The two enantionmers of 1 ((3 S ) ‐ 1a and (3 R ) ‐ 1b ) and 2 ((6a S ,12a S )‐ 2a and (6a R ,12a R )‐ 2b ) were calculated for ECD spectra.…”

Section: Resultsmentioning

confidence: 99%

Two New Flavonoids from Derris eriocarpa How

Lou

Tan

et al. 2016

Helvetica Chimica Acta

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Two new flavonoids, 1 and 2, together with two known flavonoids, tephrosin (3) and 12a-hydroxy-a-toxicarol (4), were isolated from the whole herb of Derris eriocarpa HOW. The structures and absolute configurations of the new compounds were elucidated on the basis of their MS, NMR, and ECD data. The structures of the known compounds were established by extensive spectroscopic (MS, 1D-and 2D-NMR) analyses and comparison with the literature data. All compounds were isolated from D. eriocarpa for the first time. Compound 3 showed modest inhibitory activities against the growth of human cancer cells HEL and A549 with the IC 50 values of 15.03 AE 0.62 and 13.27 AE 0.39 lM, respectively.

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“…The ECD curves were extracted by SpecDis 1.6 soware. 22,23 The overall ECD curves of all the compounds were weighted by Boltzmann distribution aer UV correction.…”

Section: Methodsmentioning

confidence: 99%