Bioactive Fatty Acids in the Resolution of Chronic Inflammation in Skin Wounds

Jara, Carlos Poblete; Mendes, Nelson F.; Prado, Thaís Paulino do; Araújo, Eliana P.

doi:10.1089/wound.2019.1105

Cited by 35 publications

(25 citation statements)

References 127 publications

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“…Diet impacts the organism’s condition, and dietary factors are likely to modulate the effect of regenerative therapies. For our tests, we selected a fat-rich diet enriched in unsaturated fatty acids [ 55 , 56 ] fortified with vitamins A, B 5 , C, and D 3 ( Table 1 ). The diet alone did not strongly affect ear hole closure, although slight statistically significant increases were observed on days 35 and 42 ( Figure 9 a).…”

Section: Resultsmentioning

confidence: 99%

Regenerative Drug Discovery Using Ear Pinna Punch Wound Model in Mice

et al. 2022

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The ear pinna is a complex tissue consisting of the dermis, cartilage, muscles, vessels, and nerves. Ear pinna healing is a model of regeneration in mammals. In some mammals, including rabbits, punch wounds in the ear pinna close spontaneously; in common-use laboratory mice, they remain for life. Agents inducing ear pinna healing are potential regenerative drugs. We tested the effects of selected bioactive agents on 2 mm ear pinna wound closure in BALB/c mice. Our previous research demonstrated that a DNA methyltransferase inhibitor, zebularine, remarkably induced ear pinna regeneration. Although experiments with two other demethylating agents, RG108 and hydralazine, were unsuccessful, a histone deacetylase inhibitor, valproic acid, was another epigenetic agent found to increase ear hole closure. In addition, we identified a pro-regenerative activity of 4-ketoretinoic acid, a retinoic acid metabolite. Attempts to counteract the regenerative effects of the demethylating agent zebularine, with folates as methyl donors, failed. Surprisingly, a high dose of methionine, another methyl donor, promoted ear hole closure. Moreover, we showed that the regenerated areas of ear pinna were supplied with nerve fibre networks and blood vessels. The ear punch model proved helpful in testing the pro-regenerative activities of small-molecule compounds and observations of peripheral nerve regeneration.

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Section: Resultsmentioning

confidence: 99%

Regenerative Drug Discovery Using Ear Pinna Punch Wound Model in Mice

et al. 2022

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“…In previous investigations, squalene has been shown to reduce MPO and increase HO-1 gene expression in human neutrophils and monocytes treated with LPS. MPO is a human protein found mostly in neutrophil azurophilic granules and monocyte lysosomes [ 85 , 86 , 87 ]. MPO is generated when LPS is activated, and it catalyzes the development of a potent oxidant like hypochlorous acid, a 14-reactive chlorine species that accumulate in chronic inflammation sites [ 87 ].…”

Section: Squalene Anti-inflammatory Mechanismmentioning

confidence: 99%

A review on the potential of underutilized Blackjack (Biden Pilosa) naturally occurring in sub-Saharan Africa

Mtenga

Ripanda

2022

Heliyon

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“…Given their high safety profile, low cost, and ease of supplementation, dietary ω-3 PUFAs have been proposed as an adjunct therapy for their anti-inflammatory properties and ability to induce a protective effect against cutaneous diseases, including psoriasis [ 4 , 5 ] and acne vulgaris [ 6 , 7 , 8 ]. In addition, they can be topically applied to exert an anti-inflammatory effect [ 9 ] and are successful in managing psoriasis [ 5 , 10 ] and for wound healing resolution [ 11 , 12 ]. Polyunsaturated fatty acids are among the bioactives from marine resources that show potential as natural skin care agents for the development of novel cosmetics and nutricosmetics with dermatologic benefits and as promising applications for skin regeneration, photoprotection and wound healing [ 1 , 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

Extraction of Fatty Acids and Phenolics from Mastocarpus stellatus Using Pressurized Green Solvents

et al. 2021

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Polyunsaturated fatty acids are well known for their protective properties in relation to different skin diseases. Although seaweeds possess a low lipid fraction, they could act as an alternative renewable source of polyunsaturated fatty acids whenever other valuable seaweed components are also valorized. In this study, a biorefinery process using Mastocarpus stellatus as a model seaweed was proposed. The process started with the supercritical carbon dioxide extraction of the lipid and phenolic fractions. The influence of pressure during extraction with pure supercritical CO2 was studied while operating at a selected temperature and solvent flow rate. Kinetic data obtained during the ethanol-modified supercritical CO2 extraction were fitted to the spline model. Sequential processing was proposed with (i) pure CO2 to obtain a product with 30% PUFA content and ω-3:ω-6 ratio 1:1, (ii) ethanol-modified CO2 to extract phenolics, and (iii) microwave-assisted subcritical water extraction operating under previously optimized conditions for the extraction of phenolics, carrageenan and protein fractions. The composition of the supercritical extracts showed potential for use in both dietary and topical applications in skin care products. The remaining solids are suitable for the extraction of other valuable fractions.

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Bioactive Fatty Acids in the Resolution of Chronic Inflammation in Skin Wounds

Cited by 35 publications

References 127 publications

Regenerative Drug Discovery Using Ear Pinna Punch Wound Model in Mice

Regenerative Drug Discovery Using Ear Pinna Punch Wound Model in Mice

A review on the potential of underutilized Blackjack (Biden Pilosa) naturally occurring in sub-Saharan Africa

Extraction of Fatty Acids and Phenolics from Mastocarpus stellatus Using Pressurized Green Solvents

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