Bioactive food components for managing cellular senescence in aging and disease: A critical appraisal and perspectives

Sharma, Rohit

doi:10.1016/j.phanu.2021.100281

Cited by 14 publications

(11 citation statements)

References 235 publications

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“…Dietary supplementation with potent anti-inflammatory supplements including omega-3 fatty acids, green tea, polyphenol, blueberry extracts, milk thistle extracts (silymarin) and stinging nettle extracts is a particularly attractive approach to combating low-grade inflammation. Such nutritional components have proven to selectively alleviate extrinsic cellular stressors, cellular senescence and consequently the inflammation state [137,174,175]. On the other hand, regular exercise and physical activity significantly contribute to the suppression of inflammation via preventing cellular senescence.…”

Section: Other Mechanisms Involved In Inflammation-induced Pathologic...mentioning

confidence: 99%

Interplay between Inflammation and Pathological Bone Resorption: Insights into Recent Mechanisms and Pathways in Related Diseases for Future Perspectives

Terkawi

Matsumae

Shimizu

et al. 2022

IJMS

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Bone is a mineralized and elastic connective tissue that provides fundamental functions in the human body, including mechanical support to the muscles and joints, protection of vital organs and storage of minerals. Bone is a metabolically active organ that undergoes continuous remodeling processes to maintain its architecture, shape, and function throughout life. One of the most important medical discoveries of recent decades has been that the immune system is involved in bone remodeling. Indeed, chronic inflammation has been recognized as the most significant factor influencing bone homeostasis, causing a shift in the bone remodeling process toward pathological bone resorption. Bone osteolytic diseases typified by excessive bone resorption account for one of the greatest causes of disability worldwide, with significant economic and public health burdens. From this perspective, we discuss the recent findings and discoveries highlighting the cellular and molecular mechanisms that regulate this process in the bone microenvironment, in addition to the current therapeutic strategies for the treatment of osteolytic bone diseases.

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Section: Other Mechanisms Involved In Inflammation-induced Pathologic...mentioning

confidence: 99%

Interplay between Inflammation and Pathological Bone Resorption: Insights into Recent Mechanisms and Pathways in Related Diseases for Future Perspectives

Terkawi

Matsumae

Shimizu

et al. 2022

IJMS

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“…Surprisingly, a recent study demonstrated that similar to tumorous cells, SC can also develop immune evasive properties which may augment their survival and persistence in tissues thereby indicating a deeper relationship between host immunity and SC [ 66 ]. Taken together, it is evident that accumulation of SC is harmful, and strategies aimed at prevention or regression of cellular senescence during aging are desirable to alleviate morbidity and mortality in the elderly [ 67 ].…”

Section: Cellular Senescence Links Biological Agingmentioning

confidence: 99%

Emerging Interrelationship Between the Gut Microbiome and Cellular Senescence in the Context of Aging and Disease: Perspectives and Therapeutic Opportunities

Sharma

2022

Probiotics & Antimicro. Prot.

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Graphical abstract The significance of diversity, composition, and functional attributes of the gut microbiota in shaping human health is well recognized. Studies have shown that gut microbiota is closely linked to human aging, and changes in the gut microbiome can predict human survival and longevity. In addition, a causal relationship between gut microbiota dysbiosis and chronic age-related disorders is also becoming apparent. Recent advances in our understanding of the cellular and molecular aspects of biological aging have revealed a cellular senescence-centric view of the aging process. However, the association between the gut microbiome and cellular senescence is only beginning to be understood. The present review provides an integrative view of the evolving relationship between the gut microbiome and cellular senescence in aging and disease. Evidence relating to microbiome-mediated modulation of senescent cells, as well as senescent cells-mediated changes in intestinal homeostasis and diseases, have been discussed. Unanswered questions and future research directions have also been deliberated to truly ascertain the relationship between the gut microbiome and cellular senescence for developing microbiome-based age-delaying and longevity-promoting therapies.

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“…In short, a preconditioning signal leading to cellular protection through hormesis [92] is an important redox dependent agingassociated to free radicals' species accumulation and inflammatory responses involved in neurodegenerative/neuroprotective mechanisms [93]. Several phytochemicals are being investigated to elucidate their role in mitochondrial protection [94][95][96] and it is conceivable to hypothesize a similar mechanism of action of KB.…”

Section: Ketone Bodies As Potential Effectors Of Fastingmentioning

confidence: 99%

Traditional and Medical Applications of Fasting

et al. 2022

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Fasting has been practiced for millennia, for religious, ethical, or health reasons. It is also commonplace among different species, from humans, to animals, to lower eukaryotes. Research on fasting is gaining traction based on recent studies that show its role in many adaptive cellular responses such as the reduction of oxidative damage and inflammation, increase of energy metabolism, and in boosting cellular protection. In this expert review, we recount the historical evolution of fasting and we critically analyze its current medical applications, including benefits and caveats. Based on the available data, we conclude that the manipulation of dietary intake, in the form of calorie restriction, intermittent fasting, dietary restriction with the exclusion of some nutrients, prolonged fasting, and so forth, is anthropologically engraved in human culture possibly because of its positive health effects. Indeed, many studies show that fasting ameliorates many biochemical parameters related to cardiovascular and cancer risk, and neurodegeneration. Mechanistic studies are plentiful, but largely limited to cell cultures or laboratory animals. Understandably, there are no controlled trials of any form of fasting that gauge the effects on [any cause] mortality. Physicians should be aware that misinformation is pervasive and that their patients often adopt dietary regimens that are far from being clinically validated. Moreover, doctors are often unaware of their patients’ religious or traditional fasting and of its potential health effects. Based on current evidence, no long-term fasting should be undertaken without medical supervision until future research will hopefully help shed further light on fasting and its effects on human health.

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Bioactive food components for managing cellular senescence in aging and disease: A critical appraisal and perspectives

Cited by 14 publications

References 235 publications

Interplay between Inflammation and Pathological Bone Resorption: Insights into Recent Mechanisms and Pathways in Related Diseases for Future Perspectives

Interplay between Inflammation and Pathological Bone Resorption: Insights into Recent Mechanisms and Pathways in Related Diseases for Future Perspectives

Emerging Interrelationship Between the Gut Microbiome and Cellular Senescence in the Context of Aging and Disease: Perspectives and Therapeutic Opportunities

Traditional and Medical Applications of Fasting

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