Bioactive Fraction of Geopropolis from<i>Melipona scutellaris</i>Decreases Neutrophils Migration in the Inflammatory Process: Involvement of Nitric Oxide Pathway

Franchin, Marcelo; Cunha, Marcos Guilherme da; Denny, Carina; Napimoga, Marcelo Henrique; Cunha, Thiago M.; Bueno‐Silva, Bruno; Alencar, Severino Matias de; Ikegaki, Masaharu; Rosalen, Pedro Luiz

doi:10.1155/2013/907041

Cited by 41 publications

(32 citation statements)

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“…Among bee products, propolis has been the subject of pharmacological studies due to its antimicrobial (Simões et al 2008), anti-inflammatory (Franchin et al 2013), antioxidant properties (Perchyonok et al 2013), among others. This biological potential is due to a synergy that occurs between the many constituents.…”

Section: Introductionmentioning

confidence: 99%

Physicochemical properties and antioxidant capacity of propolis of stingless bees (Meliponinae) and Apisfrom two regions of Tocantins, Brazil

et al. 2016

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The composition of propolis depends on time, vegetation and the location of the collection area. The objective of this study was to determine the physicochemical characteristics, the concentration of phenol compounds and the antioxidant capacity of propolis of native stingless bees (Meliponinae) and Apis from the State of Tocantins. Extraction with 80% ethanol (v/v) was performed in order to obtain the extracts. Parameters examined were: propolis mass loss by desiccation at 105 ºC, ashes, wax concentration and pH. Furthermore, the propolis antioxidant activity was measured, as well as the total concentration of phenol compounds. The extracts were also analyzed by high performance liquid chromatography. The total concentration of phenol compounds varied between 121.78 and 631.29 (mg GAE g . High performance liquid chromatography analysis allowed us to infer the existence of phenol compounds. The results indicated that the studied propolis samples constitute good sources of natural antioxidants. The variety of phenol compounds identified in this study, and the diverse biological functions reported in literature for these compounds indicated that this stingless bee propolis (Meliponinae) and Apis has a high pharmacological potential. KEYWORDS: Propolis, antioxidant, phenol compounds.Propriedades físico-químicas e capacidade antioxidante de própolis de abelhas sem ferrão (Meliponinae) e Apis de duas regiões do Tocantins, Brasil RESUMO A composição da própolis depende do tempo, da vegetação e a localização da área de coleta. Este estudo teve como objetivo determinar as características físicas e químicas, o teor de compostos fenólicos e capacidade antioxidante da própolis de abelhas nativas sem ferrão (Meliponinae) e Apis do Estado do Tocantins. Para a obtenção dos extratos empregou-se extração com etanol 80% (v/v). Os parâmetros analisados foram: perda de peso por dessecação a 105 °C, cinzas, Teor de cera e pH. Além dessas foi mensurada a atividade antioxidante e o teor de compostos fenólicos totais. Adicionalmente os extratos de própolis foram também analisados por cromatografia líquida de alta eficiência. O teor de compostos fenólicos totais variou entre 121,78 e 631,29 (mg GAE g -1 ). A atividade antioxidante expressa pelo valor de CE 50 variou entre 29,81 e 845,38 µg mL -1 . As análises por cromatografia líquida de alta eficiência permitiram inferir a existência de compostos fenólicos. Os resultados indicaram que as amostras de própolis estudadas constituem boas fontes de antioxidantes naturais. A variedade de compostos fenólicos identificada neste estudo, e as diversas funções biológicas relatadas na literatura para estes compostos, indicaram que a própolis de abelhas sem ferrão (Meliponinae) e Apis tem um grande potencial farmacológico. PALAVRAS-CHAVE: Própolis, antioxidante, compostos fenólicos. Physicochemical properties and antioxidant capacity of propolis of stingless bees (Meliponinae) and Apis from two regions of Tocantins, Brazil ACTA

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Section: Introductionmentioning

confidence: 99%

Physicochemical properties and antioxidant capacity of propolis of stingless bees (Meliponinae) and Apisfrom two regions of Tocantins, Brazil

et al. 2016

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“…Moreover, it is a powerful ROS scavenger [53] as it enhances the levels of reduced glutathione (GSH) suggesting GSHdependent detoxification of free radicals [54] . Propolis also inhibits the migration of neutrophil thus reduces the inflammatory response [55] .…”

Section: Discussionmentioning

confidence: 99%

The Possible Role of Propolis in Ameliorating Paclitaxel-Induced Peripheral Neuropathy in Sciatic Nerve of Adult Male Albino Rats

Kassab

Elkaliny

2017

Egyptian Journal of Histology

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Background: Paclitaxel is a neurotoxic chemotherapeutic agent. The sensorimotor peripheral neuropathy is a serious dose limiting complication of paclitaxel therapy. Propolis is a natural honeybee product collected from plants. It has broad biological and pharmacological activities and a proposed neuroprotective role. Aim: To assess the possible protective role of propolis on paclitaxel-induced peripheral neuropathy in rat's sciatic nerve. Material and Methods: Twenty-four adult male albino rats were divided into four equal groups; control group, propolistreated group (50 mg/kg orally once daily), paclitaxel -treated group (16 mg/kg intraperitoneally once a week), and both paclitaxel & propolis-treated group. Animals were treated for 5 consecutive weeks. Specimens of sciatic nerve were processed for histological study by light and electron microscopy. Immunohistochemical study was carried out using CD68 antibody. Morphometric study and statistical analysis of light microscopic data were performed for all groups. Results: Compared to the control group, the sciatic nerve specimens of the paclitaxel-treated rats showed splitting of myelin lamellae with infolded myelin loops, together with invagination and evagination of the myelin sheath. Changes in the axons included formation of myelin figures, compression and irregularity. Schwann cells showed cytoplasmic vacuolation and dilated rER. Immunohistochemical study revealed a significant increase in the number of CD68 positive cells. On the other hand, minimal changes were observed in rats treated concomitantly with both paclitaxel and propolis, with a non-significant increase in CD68 positive cells. Conclusion: Paclitaxel induced structural changes in the myelinated fibers of sciatic nerve of albino rats. The concomitant treatment with propolis ameliorated these changes.

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“…The therapeutic properties of the geopropolis produced by different species of stingless bees have been described. The activities of geopropolis collected from the following species were related: from M. scutellaris , which presented gastroprotective and antimicrobial activities; M. fasciculata , which presented gastroprotective, antioxidant, antimicrobial, and anticancer activities; M. orbignyi , which presented antioxidant, antimicrobial and anti‐inflammatory activities; M. scutellaris , which presented anti‐inflammatory activities; and Scaptotrigona postica , which presented antiviral activities …”

Section: Introductionmentioning

confidence: 99%

“…9 The therapeutic properties of the geopropolis produced by different species of stingless bees have been described. The activities of geopropolis collected from the following species were related: from M. scutellaris, which presented gastroprotective 10 and antimicrobial 11 activities; M. fasciculata, which presented gastroprotective, 10 antioxidant, 7,11 antimicrobial, 12 and anticancer 13 activities; M. orbignyi, which presented antioxidant, antimicrobial and anti-inflammatory activities; 9 M. scutellaris, which presented anti-inflammatory activities; 14,15 and Scaptotrigona postica, which presented antiviral activities. 8 Studies investigating the geopropolis produced by M. subnitida collected in the state of Paraiba, north-eastern Brazil, have shown potential antioxidant and antinociceptive activities 16 leading to the isolation and characterisation of phenylpropanoids…”

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confidence: 99%

Characterisation of phenolic compounds by UPLC‐QTOF‐MS/MS of geopropolis from the stingless bee Melipona subnitida (jandaíra)

Souza

Silva

et al. 2018

Phytochemical Analysis

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Bioactive Fraction of Geopropolis fromMelipona scutellarisDecreases Neutrophils Migration in the Inflammatory Process: Involvement of Nitric Oxide Pathway

Cited by 41 publications

References 28 publications

Physicochemical properties and antioxidant capacity of propolis of stingless bees (Meliponinae) and Apisfrom two regions of Tocantins, Brazil

Physicochemical properties and antioxidant capacity of propolis of stingless bees (Meliponinae) and Apisfrom two regions of Tocantins, Brazil

The Possible Role of Propolis in Ameliorating Paclitaxel-Induced Peripheral Neuropathy in Sciatic Nerve of Adult Male Albino Rats

Characterisation of phenolic compounds by UPLC‐QTOF‐MS/MS of geopropolis from the stingless bee Melipona subnitida (jandaíra)

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