Bioactive furanocoumarins from the berries of <i>Zanthoxylum americanum</i>

Saqib, Qazi Najam us; Hui, Yu‐Hua; Anderson, Jon E.; McLaughlin, Jerry L.

doi:10.1002/ptr.2650040604

Cited by 16 publications

(6 citation statements)

References 11 publications

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“…For example, most Zanthoxylum extracts have antioxidant properties. [ ][ ] These also account for several types of biological activities such as hepatoprotective, anti‐inflammatory or antibiotic effects, developed by the pharmaceutical, medical or biocides industries . Zanthoxylum fruits or leaves are interesting for the production of high value essential oils designed to cosmetics and fragrances industries.…”

Section: Introductionmentioning

confidence: 99%

Study of Some Zanthoxylum Species by Chemical and DNA Analysis Approaches

Périchet¹,

Florian²,

Dupouyet³

et al. 2018

Chemistry & Biodiversity

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The authentication and traceability of spices is a major concern for industrials and consumers. We focused on species from Zanthoxylum genera which are used for many different applications by local populations and also for trading as spices (dried pericarps or whole fruits). In this case, literature gives contradictory data about botanical names, and commercial labelling is often confusing. We studied commercial fruits pericarps extracts obtained by supercritical CO and analyzed them by GC/MS. The very complex volatile and semi volatile fractions composition of each extract is described. The barcoding method including molecular biology and phylogenetic analyses was also developed in order to check the commercial botanical identification of the raw material. This is a robust method to identify species in berries samples. We used one genetic marker to identify two Rutaceae clusters, including several species of Zanthoxylum genus. These results indicate that Fagara and Zanthoxylum groups could be considered as two different genera. Combination of chemical analysis and DNA analysis provides an original approach to increase chemical and botanical Zanthoxylum genus knowledge.

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Section: Introductionmentioning

confidence: 99%

Study of Some Zanthoxylum Species by Chemical and DNA Analysis Approaches

Périchet¹,

Florian²,

Dupouyet³

et al. 2018

Chemistry & Biodiversity

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“…It was extensively used by Native Americans and nineteenth century physicians (Bruneton, 1995;Cluaus, 1959). Earlier phytochemical work on the bark and berries resulted in the identification of some coumarins and alkaloids (Fish et al, 1975;Saqib et al, 1990;Robert and Sabramanin, 1937). Coumarins constitute a major class of O-heterocyclic natural products with widespread distribution and broad pharmacological profile (Fish et al, 1976;Murray, 1991;Murray and Forbes, 1967), including anticancer, carcinogenic and antiviral (HIV) activities (Gustatson et al, 1994).…”

Section: Introductionmentioning

confidence: 99%

Cytotoxic coumarins and lignans from extracts of the northern prickly ash (Zanthoxylum americanum)

Still

Sacalis

et al. 2001

Phytotherapy Research

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Four pyranocoumarins; dipetaline, alloxanthoxyletin, xanthoxyletin and xanthyletin; and two lignans; sesamin and asarinin were isolated from the northern prickly ash, Zanthoxylum americanum. To varying degrees, all inhibited the incorporation of tritiated thymidine into human leukaemia (HL-60) cells. Dipetaline was the most active with an IC(50) of 0.68 ppm, followed by alloxanthoxyletin (1.31 ppm), sesamin (2.71 ppm), asarinin (4.12 ppm), xanthoxyletin (3.48 ppm) and xanthylletin (3.84 ppm).

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“…In studies done on this species, from the bark of Z. schinifolium were isolated auraptene 33 and collinine 34, terpenylcoumarins with antiplatelet activity and inhibitory activity of DNA replication in hepatitis B virus . Furanocoumarins with cytotoxic activity against human tumor cells have been found in berries of Z. americanum, for example psoralen 35 (Saquib et al, 1990).…”

Section: Coumarinsmentioning

confidence: 99%