Bioactive glass as a drug delivery system of tetracycline and tetracycline associated with β-cyclodextrin

Domingues, Rosana Zacarias; Cortés, María Esperanza; Gomes, Tomás Andrade Magalhães; Diniz, Henrique; Freitas, Camila S.; Gomes, Jânderson Breder; Faria, Ana Maria Caetano; Sinisterra, Rubén D.

doi:10.1016/s0142-9612(03)00524-6

Cited by 113 publications

(62 citation statements)

References 22 publications

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“…In vitro, BGs are able to form a surface layer of (2002) foaming (i) effervescent salts (ammonium bicarbonate) are used as porogens and mixed with an organic viscous solution/suspension of polymer/ceramic (ii) after solvent evaporation, porosity is achieved by placing scaffolds into hot water or an aqueous solution of citric acid to dissolve the salts (iii) an alternative is CO 2 -based gas Mooney et al (1996); Harris et al (1998) template technique (i) scaffolds are prepared by dipping a polyurethane sponge into a slurry of proper viscosity containing ceramic particles (ii) the impregnation step and the removal of the surplus slurry should be adjusted to obtain, after the sponge removal, a defect-free porous three-dimensional scaffold (iii) sometimes, in order to obtain mesoporous structures, surfactants may be added Vitale- Chen, Q. Z. et al (2006) sol-gel (i) scaffolds are prepared by dissolving inorganic metal salts or metal organic compounds in a solvent where a series of hydrolysis and polymerization reactions allow the formation of a colloidal suspension ('sol') (ii) after casting the 'sol' into a mould, a wet 'gel' is formed (iii) with further drying and heat treatment, the 'gel' is converted into dense ceramic or glass articles Domingues et al (2004) powder compaction (i) scaffolds are prepared by compressing the polymers/ ceramics using projectiles or punch and dies (ii) the velocity of compaction of the projectile or punch and dies is adjusted to achieve powder consolidation and the desired porosity (iii) the process can include sintering (iv) an alternative is to use uniaxial or isostatic pressing Miyai et al (2008) microcrystalline HA when in contact with simulated body fluid (SBF) (Kim et al 1995;Hench 1998;Fujibayashi et al 2003). More recently, it has been discovered that ionic dissolution products released from silica-based BGs upregulate seven families of genes found in osteoblasts (Xynos et al 2001).…”

Section: Inorganic Scaffoldsmentioning

confidence: 99%

Bone tissue engineering therapeutics: controlled drug delivery in three-dimensional scaffolds

Mouriño

Boccaccını

2009

J. R. Soc. Interface.

483

298

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This paper provides an extensive overview of published studies on the development and applications of three-dimensional bone tissue engineering (TE) scaffolds with potential capability for the controlled delivery of therapeutic drugs. Typical drugs considered include gentamicin and other antibiotics generally used to combat osteomyelitis, as well as anti-inflammatory drugs and bisphosphonates, but delivery of growth factors is not covered in this review. In each case reviewed, special attention has been given to the technology used for controlling the release of the loaded drugs. The possibility of designing multifunctional three-dimensional bone TE scaffolds for the emerging field of bone TE therapeutics is discussed. A detailed summary of drugs included in three-dimensional scaffolds and the several approaches developed to combine bioceramics with various polymeric biomaterials in composites for drug-delivery systems is included. The main results presented in the literature are discussed and the remaining challenges in the field are summarized with suggestions for future research directions.

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Section: Inorganic Scaffoldsmentioning

confidence: 99%

Bone tissue engineering therapeutics: controlled drug delivery in three-dimensional scaffolds

Mouriño

Boccaccını

2009

J. R. Soc. Interface.

483

298

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“…Chromatography (Attebery, 1975;Rocca and Rouchouse, 1976;Fahlvik et al, 1990;Zhang and El Rassi, 1999;Spegel et al, 2001) Imaging (Cuthbertson et al, 2003;Cavalieri et al, 2005;Huang et al, 2006;Klibanov, 2006) Filling of defects (Schepers et al, 1991;Guicheux et al, 1997;Santos et al, 1998;Schepers et al, 1998;Falaize et al, 1999;Huygh et al, 2002;Day et al, 2004;Domingues et al, 2004;Gosain, 2004) Adjuvants in vaccines (Ohagan et al, 1993;Moore et al, 1995;Nakaoka et al, 1995;Ertl et al, 1996;Heritage et al, 1996;Ohagan et al, 1997;Stertman et al, 2006) Cell culture (Malda et al, 2003b;Xu et al, 2003;Zhang et al, 2003;Liu and Wu, 2004;Yokomizo et al, 2004;Hong et al, 2005;Melero-Martin et al, 2006) Drug delivery (Herrmann and Bodmeier, 1995;Guicheux et al, 1997;Berthold et al, 1998;Herrmann and Bodmeier, 1998;Jeong et al, 1998;Cruaud et al, 1999;Ganza-Gonzalez et al, 1999;Lam et al, 2000;Lim et al, 2000;…”

Section: Applications In the Biomedical Field Referencesmentioning

confidence: 99%

Materials in particulate form for tissue engineering. 1. Basic concepts

Silva

Ducheyne

Reis

2007

J Tissue Eng Regen Med

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For biomedical applications, materials small in size are growing in importance. In an era where 'nano' is the new trend, micro-and nano-materials are in the forefront of developments. Materials in the particulate form aim to designate systems with a reduced size, such as micro-and nanoparticles. These systems can be produced starting from a diversity of materials, of which polymers are the most used. Similarly, a multitude of methods are to produce particulate systems, and both materials and methods are critically reviewed here. Among the varied applications that materials in the particulate form can have, drug delivery systems are probably the most prominent, as these have been in the forefront of interest for biomedical applications. The basic concepts pertaining to drug delivery are summarized, and the role of polymers as drug delivery systems conclude this review. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE R E V I E W A R T I C L E

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“…Furthermore, the microbiological test showed better antimicrobial activity for complexcoated vascular prostheses, and also showed that a wide range of antibiotics can be included into CDs, which makes them potential for the treatment of multigerm vascular prostheses infections. 56,60,61 Not only are CDs used alone as a carrier, but they are also incorporated into other carriers, such as bioactive glasses 62 and polymers, 63 to obtain an extended release.…”

Section: Antibiotic Materials Extended-release Dds P Gao Et Almentioning

confidence: 99%

Recent advances in materials for extended-release antibiotic delivery system

et al. 2011

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To maintain antimicrobial activity, frequent administration of conventional formulations of many antibiotics with short half-life is necessary. Otherwise, concentration under MIC occurs frequently in the course of anti-infective treatment, which induces antibiotic resistance. By maintaining a constant plasma drug concentration over MIC for a prolonged period, extended-release dosage forms maximize the therapeutic effect of antibiotics while minimizing antibiotic resistance. Another undoubted advantage of extended-release formulation is improved patient compliance. For better release properties, many materials have been introduced into the matrix and coating extended-release system in the past few years. Materials that have been widely used in industry are hydrophilic matrix materials such as hydroxypropylmethylcellulose. The excellent biocompatibility and extensive laboratory studies provide biodegradable polymers great potential for industrial applications. In addition, it seems like the researches on tailored materials that are obtained by chemical modification of the existing materials or combination of different carriers in physical mixtures have a long way to go. Meanwhile, with the development of polymers and inorganic porous nanocarriers, nanotechnology is applied increasingly for the extended delivery of antibiotics. This review highlights the development of materials used in extended-release formulation and nanoparticles for antibiotic delivery. We also provide an overview of the antibiotic extended-release products that have provided clinical benefit or are undergoing the clinical trial.

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Bioactive glass as a drug delivery system of tetracycline and tetracycline associated with β-cyclodextrin

Cited by 113 publications

References 22 publications

Bone tissue engineering therapeutics: controlled drug delivery in three-dimensional scaffolds

Bone tissue engineering therapeutics: controlled drug delivery in three-dimensional scaffolds

Materials in particulate form for tissue engineering. 1. Basic concepts

Recent advances in materials for extended-release antibiotic delivery system

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