Bioactive glass–chitosan composite coatings on PEEK: Effects of surface wettability and roughness on the interfacial fracture resistance and in vitro cell response

Wei, Hong; Guo, Fangwei; Chen, Jianwei; Wang, Xin M.; Zhao, Xiaofeng; Xiao, Ping

doi:10.1016/j.apsusc.2018.01.183

Cited by 51 publications

(29 citation statements)

References 61 publications

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“…Moreover, zinc-modified sulfonated PEEK exhibits the property of bacteriostasis and immunomodulation (Liu et al., 2018 ), and the dexamethasone plus minocycline-loaded liposome-modified PEEK reveals antibacterial ability and anti-inflammatory property (Xu et al., 2019 ). These reports illustrate the feasibility of the achievement of dual- or triple-functional PEEK (Gan et al., 2016 ; Hong et al., 2018 ). It still requires a simple and cost-effective strategy without potential biotoxicity or the need of complex device for PEEK modification with promoted bioactivity (Zheng et al., 2019 ).…”

Section: Introductionmentioning

confidence: 60%

Facile surface functional polyetheretherketone with antibacterial and immunoregulatory activities for enhanced regeneration toward bacterium-infected bone destruction

et al. 2021

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Existing biologically inert or unmodified implants to treat infectious bone defects or osteomyelitis still cannot effectively solve bacterial infection and osseointegration. In this work, a simple co-deposition strategy was developed to modify porous polyetheretherketone (PEEK) with improved antibacterial activity and controllable immunoregulatory ability. After PEEK was treated by H 2 SO 4 to obtain porous PEEK (SPEEK), the self-polymerization of dopamine was operated on SPEEK in the solution of dopamine and gentamicin sulfate (GS) to prepare polydopamine (pDA) and GS layer-modified SPEEK (labeled as SPEEK–pDA–GS). The morphology, surface property, and molecular structure of SPEEK–pDA–GS were investigated. Besides the antibacterial property of SPEEK–pDA–GS ascribed to the successful immobilization of GS, SPEEK–pDA–GS exhibited promoted osseointegration through the results of mineralization, alkaline phosphatase (ALP) levels and osteogenic gene expression. Furthermore, the evaluation of the cell proliferation suggested that SPEEK–pDA–GS possessed the biocompatibility and the immunoregulatory ability that induced macrophages to anti-inflammatory M2 phenotype. Using rat as model, in vivo results containing X-ray, μ-CT, immunohistochemistry, and pathological analysis showed the excellent healing effect of SPEEK–pDA–GS on bone defect with infection with biological safety. This work illustrates a new insight into the simple and effective modification of PEEK and other implants with antibacterial, immunoregulatory, and osseointegration abilities for clinical requirement.

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Section: Introductionmentioning

confidence: 60%

Facile surface functional polyetheretherketone with antibacterial and immunoregulatory activities for enhanced regeneration toward bacterium-infected bone destruction

et al. 2021

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“…PEKK is a promising implantable material for load-bearing bone replacement owing to its superior mechanical strength, biocompatibility and biostability. However, the bioinert nature and hydrophobicity of PEKK limit its efficiently integration with host bone tissue, which can cause the loosening and ultimate failure of implantation [ 9 ]. Both Ta and SN possess excellent outstanding osteogenic activity and can be integrated with the host bone, while SN possesses additional outstanding antibacterial activity [ 27 , 30 ].…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, osseointegration of PAEK is considered as the gold standard for successful implantation in vivo [ 8 ]. Several strategies (e.g., surface modification with physical, chemical and biological ways) have been applied to increase the surface bioactivity of PAEK (e.g., PEEK) to facilitate new bone regeneration and osteointegration, such as plasma treatment, NaOH-etched/boron-doped nanohydroxyapatite coating or a bone morphogenetic protein-2 immobilized collagen coating on PEEK [ [9] , [10] , [11] ]. However, these surface modification strategies may not be sufficient to produce biomedical implants with excellent osteogenic bioactivity and stability for clinical applications [ 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

A microporous surface containing Si3N4/Ta microparticles of PEKK exhibits both antibacterial and osteogenic activity for inducing cellular response and improving osseointegration

Mei

Wang

et al. 2021

Bioactive Materials

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As an implantable biomaterial, polyetherketoneketone (PEKK) exhibits good mechanical strength but it is biologically inert while tantalum (Ta) possesses outstanding osteogenic bioactivity but has a high density and elastic modulus. Also, silicon nitride (SN) has osteogenic and antibacterial activity. In this study, a microporous surface containing both SN and Ta microparticles on PEKK (STP) exhibiting excellent osteogenic and antibacterial activity was created by sulfonation. Compared with sulfonated PEKK (SPK) without microparticles, the surface properties (roughness, surface energy, hydrophilicity and protein adsorption) of STP significantly increased due to the SN and Ta particles presence on the microporous surface. In addition, STP also exhibited outstanding antibacterial activity, which inhibited bacterial growth in vitro and prevented bacterial infection in vivo because of the presence of SN particles. Moreover, the microporous surface of STP containing both SN and Ta particles remarkably induced response (e.g., proliferation and differentiation) of rat bone mesenchymal stem (rBMS) cells in vitro . Furthermore, STP significantly improved new bone regeneration and osseointegration in vivo . Regarding the induction of cellular response in vitro and improvement of osseointegration in vivo , the microporous surface containing Ta was better than the surface with SN particles. In conclusion, STP with optimized surface properties activated cellular responses in vitro , enhanced osseointegration and prevented infection in vivo . Therefore, STP possessed the dual biofunctions of excellent osteogenic and antibacterial activity, showing great potential as a bone substitute.

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“…Physically adsorbed coatings have been applied to PEEK through a variety of methods, including dip coating, poly(dopamine) (PDA) mussel‐like adhesion, layer‐by‐layer (LbL) assembly of polyelectrolyte multilayer films, and the adsorption of proteins or drugs . LbL film deposition has been used to change the surface chemistry of PEEK by adsorbing new functional groups to its surface as the molecules used to build the films contain charged functional groups.…”

Section: Surface Modification Techniquesmentioning

confidence: 99%

Surface Modification Strategies to Improve the Osseointegration of Poly(etheretherketone) and Its Composites

Buck

Cerruti

2019

Macromolecular Bioscience

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In the last 5 years, a wide variety of surface modification strategies are explored to improve the integration of poly(etheretherketone) (PEEK) implants with bone. Since PEEK does not support bone on‐growth, its surface properties need to be tailored to promote osteogenesis at the bone‐implant interface. Surface modifications applied to achieve this response range from simple surface morphology changes to the deposition of osteoconductive coatings. Of the many methods, titanium and/or hydroxyapatite coatings, extrusion to create surface pores, and an accelerated neutral atom beam treatment have been approved by the U.S. Food and Drug Administration to improve the integration of PEEK spinal cages. The success of these surface modifications brings hope for the clinical translation of other techniques in the future, but there are several limitations that may be preventing other treatments from reaching the clinic. This review describes numerous strategies that have been applied to PEEK‐based implants for improving their osseointegration and enhancing their antibacterial properties. The review concludes with a discussion about future directions for the field and provides suggestions for advancing clinical translation of surface‐modified PEEK implants to improve the lives of patients in need of these implants.

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Bioactive glass–chitosan composite coatings on PEEK: Effects of surface wettability and roughness on the interfacial fracture resistance and in vitro cell response

Abstract: Bioactive glass-chitosan composite coatings on PEEK: Effects of surface wettability and roughness on the interfacial fracture resistance and in vitro cell response

Cited by 51 publications

References 61 publications

Facile surface functional polyetheretherketone with antibacterial and immunoregulatory activities for enhanced regeneration toward bacterium-infected bone destruction

Facile surface functional polyetheretherketone with antibacterial and immunoregulatory activities for enhanced regeneration toward bacterium-infected bone destruction

A microporous surface containing Si3N4/Ta microparticles of PEKK exhibits both antibacterial and osteogenic activity for inducing cellular response and improving osseointegration

Surface Modification Strategies to Improve the Osseointegration of Poly(etheretherketone) and Its Composites

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