Bioactive glass for dentin remineralization: A systematic review

Fernando, Delihta; Attik, Nina; Pradelle-Plasse, Nelly; Jackson, Phil; Grosgogeat, Brigitte; Colon, Pierre

doi:10.1016/j.msec.2017.03.083

Cited by 104 publications

(64 citation statements)

References 56 publications

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“…The mechanism of the high bioactivity of bioglass could be described as the follows; leaching out of ions from the glass to form carbonated calcium deficient hydroxyl apatite, which binds to the collagen of the tissue. Moreover the leached ions regulate genes that encode growth factors and stimulate the secretion of bone matrix via osteogenic cells [7]. The term bioactive material appears first by Hench et al to describe the interfacial bond developed between the calcium silico-phosphate glass (bioactive glass) and host tissue, due to the unique surface reactivity of bioactive glasses [8].…”

Section: Introductionmentioning

confidence: 99%

“…The term bioactive material appears first by Hench et al to describe the interfacial bond developed between the calcium silico-phosphate glass (bioactive glass) and host tissue, due to the unique surface reactivity of bioactive glasses [8]. Nowadays there are a new paradigm in bioactivity concept, it expand to comprise the ability of a bioactive material to contribute calcium and phosphate ions to help rebuild demineralized dental tissues [7,9]. Previous investigations have suggested that incorporation of bioactive glass into conventional and resin-modified glass ionomer enhance mineral formation [10,11].…”

Section: Introductionmentioning

confidence: 99%

“…Currently, there is a trend for the development of nano-sized dental materials that have a bioactive function, in addition to their inherent properties [13]. Bioglass has been used in orthopedics and dentistry in many applications such as bone repair, implants coating and as a scaffolds for bone repair [6,7]. Bioglass have a proven excellent ability for apatite formation.…”

Section: Introductionmentioning

confidence: 99%

“…Bioglass have a proven excellent ability for apatite formation. Therefore, recent investigations have considered bioglass as one of the most suggested materials for remineralization of hard dental tissues [7]. Therefore, the aim of this study is to bioactivate the conventional zinc phosphate dental cement by incorporation of nano-sized bioglass.…”

Section: Introductionmentioning

confidence: 99%

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Novel Bioactive Zinc Phosphate Dental Cement with Low Irritation and Enhanced Microhardness

Hamdy

El-Korashy

2018

e-J. Surf. Sci. Nanotech.

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Wide range of cements used in dentistry for cementation of dental restorations to tooth structure. The properties of dental cements should be carefully considered during their selection for achievement of long-term clinical performance of cemented dental restorations. Conventional zinc phosphate cement and other types of dental cements except polycarboxylate and glass-ionomer depend on their retention to tooth structure upon mechanical bonding. Bioactive glasses have shown a talented result in minerals regeneration. Therefore, the aim of this article is to create bioactivate zinc phosphate dental cement by incorporation of nano-sized bioglass. A total of 20 specimens; 10 specimens per type of cement were prepared. The control group was made by mixing the conventional zinc phosphate dental cement. The other group was made by addition of 5 wt% nano-sized bioactive glass powders (45S5) to the conventional zinc phosphate dental cement. The fresh mix packed into cylindrical Teflon molds and then stored in deionized water for 7 days. The pH variations were measured immediately after immersion and after 7 days storage using pH meter. Calcium and phosphorus ion release were measured using inductively coupled plasma optical emission spectroscopy. It also evaluated the surface microhardness of the experimental cements using digital Vickers hardness tester. Regarding pH changes mean values, the bioglass contained zinc phosphate cement group showed significantly higher mean pH values than control group. As regards the bioglass contained zinc phosphate cement group; there was a significant increase in mean pH values after setting as well as after 7 days storage. While in control group, there was a significant decrease in mean pH values after setting followed by a significant increase in mean pH values after 7 days storage. Regarding calcium and phosphorus ions release mean values, the bioglass contained zinc phosphate cement group showed significantly higher mean values than the other control group. Regarding surface microhardness, the bioglass contained zinc phosphate cement group showed significantly higher mean surface microhardness values than control group. In conclusion, bioactivation of conventional zinc phosphate cement by addition of nano-sized bioglass filler leads to calcium and phosphorus ions release which may be beneficial for chemical bonding to tooth structure with enhanced surface microhardness and minimal irritating effect.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Novel Bioactive Zinc Phosphate Dental Cement with Low Irritation and Enhanced Microhardness

Hamdy

El-Korashy

2018

e-J. Surf. Sci. Nanotech.

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“…Casein phosphate is for instance known to inhibit demineralization of enamel in vitro; clinical evidence of remineralization of enamel and dentin by casein phosphate is however today still lacking 13 . Likewise, bioactive glass was shown to have remineralization potential in vitro, while this effect has so far not been proven in vivo 14 . Another remineralization strategy concerns biomimetic analogs of noncollagenous proteins 2,15 .…”

mentioning

confidence: 99%

Three-dimensional observation and analysis of remineralization in dentinal caries lesions

Nagaoka

Nakamura

Hara

et al. 2020

Sci Rep

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the remineralization mechanism in dental caries lesions is not completely understood. this study reports on ultrastructural and chemical changes observed within arrested caries lesions. carious human teeth were observed using scanning electron microscopy (SeM) and focused-ion-beam (fiB)-SeM. the crystals detected in the caries lesions were characterized by transmission electron microscopy (TEM), along with chemical element mapping using energy-dispersive spectroscopy (EDS)-STEM. FIB-SEM 3D reconstructions revealed a severely damaged dentin surface abundantly covered by bacteria. Although the dentin tubules were clogged up to a depth of 100 μm, bacterial invasion into dentin tubules was not observed. TEM crystal analysis and EDS-STEM revealed the presence of Ca and P, as well as of Mg within the HAp crystals deposited inside the dentin tubules. It was concluded that extensive remineralization with deposition of Mg-HAp crystals had occurred in dentin tubules of caries-arrested dentin. Understanding the natural remineralization process is thought to be helpful for developing clinical biomimetic remineralization protocols.Dental caries is the most prevalent health condition in the world 1,2 . This disease is a dysbiosis caused by undisturbed bacterial accumulations, which can be up regulated by the presence of fermentable carbohydrates and down regulated by fluoride. Although salivary flow rate has its role in the process, the general and main etiologic cause is undoubtedly undisturbed biofilm accumulations with release of metabolic acids leading to substantial mineral loss from the tooth structure 3,4 . When the pH of the oral cavity is neutral and saliva is sufficiently saturated with calcium and phosphate, remineralization by mineral deposition will occur 5 . The caries process is well documented to progress when the balance between demineralization and remineralization is disturbed 6 . However, the process of caries initiation is not yet fully described and understood.Remineralization of carious dentin has been investigated before. Lesters and Boyde 6 documented the crystal formation and described the crystal structure of enamel and dentinal caries using SEM and TEM. Ogawa et al. investigated the transparent and sub-transparent layers of caries lesions by SEM and measured the different layer's surface hardness. They found that apatite was deposited in the tubules of the transparent and sub-transparent caries layers 7 . Frank and Voegel 8 also observed partially and completely calcified dentin tubules in the area between the translucent zone of carious dentin and inner dentin. However, they did not report the presence of remineralized dentin in the immediate surrounding of the carious lesion. Later, several researchers documented the crystal structure of demineralized dentin using TEM [8][9][10][11] . Zavgorodny et al. 10,11 observed a transparent zone close to the demineralized caries area. This transparent zone constitutes carious dentinal tissue with intratubular mineralization. In their study, remineralization...

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