Bioactive glass S53P4 in repair of septal perforations and its interactions with the respiratory infection-associated microorganismsHeamophilus influenzae andStreptococcus pneumoniae

Abstract

Interpositional grafts between mucoperiosteal flaps are commonly used in the repair of septal perforations. We studied the use of bioactive glass (BAG) S53P4 as an interpositional graft in 11 patients suffering from septal perforations. In aqueous environments, ions are released from the BAG and the pH rises in its vicinity, both of which may influence the growth and adhesion of microorganisms. Thus, we also studied the effects of the BAG S53P4 as granules or discs on the respiratory infection-associated microorganisms Haemophilus influenzae and Streptococcus pneumoniae. Growth inhibition was studied using an agar plate test and adhesion was analyzed both with and without serum precoating of the BAG S53P4. The perforations were successfully closed in 10 of 11 patients. One patient had a near total septum perforation, which could not be closed. No BAG-associated infections were seen during the follow-up. The BAG S53P4 did not show any clear growth inhibition of the microorganisms, which showed low adhesion to the material. Serum precoating increased the adsorption. Thus, uncoated BAG S53P4 seems to be a good graft in the repair of septal perforations.

Fiber glass–bioactive glass composite for bone replacing and bone anchoring implants

“…In addition, the ion dissolution from the bioactive glasses changing the ion concentration and increasing the pH of the interfacial solution affects the viability of several anaerobic and aerobic bacteria [50][51][52][53][54].…”

Fechamento de perfuração septal nasal em coelhos com celulose bacteriana

“…Although relatively inert from the biological standpoint, after its placement on the receiving site, a fibrous capsule can cover it with time, causing tangible mobility and consequently greater likelihood of migration and extrusion 24 . Stoor et al 25 studied the septal closure and infection by Haemophilus influenza and Streptococcus pneumoniae with the use of bioactive glass (BAG) in 11 patients with septal perforation not having contamination by these germs in any patient and being able to close the perforation in 10 cases.…”

Effect of S53P4 bone substitute on staphylococcal adhesion and biofilm formation on other implant materials in normal and hypoxic conditions

“…& R. Pérez-Tanoira ramontanoira@hotmail.com the human bone cavities tend to be hypoxic even after the successful revision surgery [8][9][10].…”

“…It provides bone conductive properties and serves as excellent reconstruction material in osteomyelitis revision surgery, in craniofacial defects and in sinus or mastoid cavity obliteration [10,12,17]. It has been shown that S53P4 has antimicrobial properties [18][19][20] probably based on several factors, including high pH and osmotic effects caused by the non physiological concentration of the dissolved ions [9,15] and that the presence of S53P4 granules interfere with bacterial biofilm production and decrease its adherence on titanium surface [18,21].…”