Bioactive Glass Scaffolds for the Repair of Load‐Bearing Bones

Rahaman, Mohamed N.; Liu, Xin; Huang, Tieshu

doi:10.1002/9781118095263.ch7

Cited by 4 publications

(4 citation statements)

References 26 publications

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“…Figure D finally reveals that the filaments welded perfectly in the vertical direction: the successful interpenetration of filaments obviously favors the mechanical properties, by minimizing the stress concentrations. This is confirmed by the data reported in Table : with a total porosity of about 60%, the compressive strength exceeded 6 MPa, comparing well with compressive strength data (in the 2‐12 MPa range) of scaffolds applicable to bone regeneration …”

Section: Resultssupporting

confidence: 84%

Biosilicate^® scaffolds produced by 3D‐printing and direct foaming using preceramic polymers

et al. 2018

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Monolithic and powdered Biosilicate®, produced by conventional glass‐ceramic technology, have been widely recognized as excellent materials for bone tissue engineering applications. In the current research, we focus on an alternative processing route for this material, consisting of the thermal treatment of silicone polymers containing micro‐sized oxide fillers, which offers a unique integration between materials synthesis and shaping. In particular, the new method allows obtaining highly porous Biosilicate® glass‐ceramics, in the form of 3D printed scaffolds and foams. 3D scaffolds were successfully fabricated by direct writing using an ink based on a silicone polymer and active inorganic fillers, followed by firing in air at 1000°C. The products showed regular geometries, large open porosity (~60 vol%) and still high compressive strength (~7 MPa). Open‐cellular foams with porosity up to ∼80 vol% were also prepared from liquid silicones mixed with several fillers, including hydrated sodium phosphate. This specific filler acted both as a foaming agent, because of the gas release by dehydration occurring at low temperature, and as a provider of liquid phase upon firing in air, again at 1000°C.

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Section: Resultssupporting

confidence: 84%

Biosilicate^® scaffolds produced by 3D‐printing and direct foaming using preceramic polymers

et al. 2018

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“…Given the presence of microcracks, the mechanical strength of the developed scaffolds is remarkable: as reported in table 1, the compressive strength (σ comp ) was 2.9±0.7 MPa for t-1 samples and 5.5±0.3 MPa for t-2 ones, respectively. These values are in good agreement with the compressive strength of natural trabecular bone, which is reported to be in the 2-12 MPa range [29]. In particular, for t-2 samples, the standard deviation is quite low, as a proof of high sample reproducibility and more reliable values.…”

Section: Morphological and Mechanical Characterization Of Scaffoldssupporting

confidence: 85%

Direct ink writing of silica-bonded calcite scaffolds from preceramic polymers and fillers

et al. 2017

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Silica-bonded calcite scaffolds have been successfully 3D-printed by direct ink writing, starting from a paste comprising a silicone polymer and calcite powders, calibrated in order to match a SiO/CaCO weight balance of 35/65. The scaffolds, fabricated with two slightly different geometries, were first cross-linked at 350 °C, then fired at 600 °C, in air. The low temperature adopted for the conversion of the polymer into amorphous silica, by thermo-oxidative decomposition, prevented the decomposition of calcite. The obtained silica-bonded calcite scaffolds featured open porosity of about 56%-64% and compressive strength of about 2.9-5.5 MPa, depending on the geometry. Dissolution studies in SBF and preliminary cell culture tests, with bone marrow stromal cells, confirmed the in vitro bioactivity of the scaffolds and their biocompatibility. The seeded cells were found to be alive, well anchored and spread on the samples surface. The new silica-calcite composites are expected to be suitable candidates as tissue-engineering 3D scaffolds for regeneration of cancellous bone defects.

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“…The data reported in Table 1 confirm the expected ‘tuning’ of porosity operating on solid loading and/or on firing temperature. With a compressive strength ranging from 2.5 ± 0.4 to 15.5 ± 1.7 MPa, the developed foams compare well with the values for cancellous bone (2–12 MPa) [ 33 , 34 ].…”

Section: Resultsmentioning

confidence: 62%

Bioactive Glass-Ceramic Foam Scaffolds from ‘Inorganic Gel Casting’ and Sinter-Crystallization

et al. 2018

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Highly porous bioactive glass-ceramic scaffolds were effectively fabricated by an inorganic gel casting technique, based on alkali activation and gelification, followed by viscous flow sintering. Glass powders, already known to yield a bioactive sintered glass-ceramic (CEL2) were dispersed in an alkaline solution, with partial dissolution of glass powders. The obtained glass suspensions underwent progressive hardening, by curing at low temperature (40 °C), owing to the formation of a C–S–H (calcium silicate hydrate) gel. As successful direct foaming was achieved by vigorous mechanical stirring of gelified suspensions, comprising also a surfactant. The developed cellular structures were later heat-treated at 900–1000 °C, to form CEL2 glass-ceramic foams, featuring an abundant total porosity (from 60% to 80%) and well-interconnected macro- and micro-sized cells. The developed foams possessed a compressive strength from 2.5 to 5 MPa, which is in the range of human trabecular bone strength. Therefore, CEL2 glass-ceramics can be proposed for bone substitutions.

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Bioactive Glass Scaffolds for the Repair of Load‐Bearing Bones

Cited by 4 publications

References 26 publications

Biosilicate^® scaffolds produced by 3D‐printing and direct foaming using preceramic polymers

Biosilicate^® scaffolds produced by 3D‐printing and direct foaming using preceramic polymers

Direct ink writing of silica-bonded calcite scaffolds from preceramic polymers and fillers

Bioactive Glass-Ceramic Foam Scaffolds from ‘Inorganic Gel Casting’ and Sinter-Crystallization

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Bioactive Glass Scaffolds for the Repair of Load‐Bearing Bones

Cited by 4 publications

References 26 publications

Biosilicate® scaffolds produced by 3D‐printing and direct foaming using preceramic polymers

Biosilicate® scaffolds produced by 3D‐printing and direct foaming using preceramic polymers

Direct ink writing of silica-bonded calcite scaffolds from preceramic polymers and fillers

Bioactive Glass-Ceramic Foam Scaffolds from ‘Inorganic Gel Casting’ and Sinter-Crystallization

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Product

Resources

About

Biosilicate^® scaffolds produced by 3D‐printing and direct foaming using preceramic polymers

Biosilicate^® scaffolds produced by 3D‐printing and direct foaming using preceramic polymers