Bioactive Glasses in Orthopedic Applications

Madison, Jena; Oliver, Joy-anne N.; Zhu, Donghui

doi:10.1007/978-3-030-34471-9_21

Cited by 3 publications

(2 citation statements)

References 28 publications

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“…Bioglass is a specialised form of glass that contains a high molar ratio of calcium, which promotes apatite crystals rendering the substance osteoconductive ( 145 ). They are formed through the heating of phosphor-silicate materials with calcium and sodium oxides which are subsequently submerged in water causing crystallisation and formation of the glass ( 146 ).…”

Section: Synthetic Bone Substitutesmentioning

confidence: 99%

“…They are formed through the heating of phosphor-silicate materials with calcium and sodium oxides which are subsequently submerged in water causing crystallisation and formation of the glass ( 146 ). The product can be made into putty for simple application or manipulated into complex 3D structures through extrusion printing, with the ability to vary the pore size to provide topographic signals to osteogenic cells ( 145 ).…”

Section: Synthetic Bone Substitutesmentioning

confidence: 99%

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Biological aspects to enhance fracture healing

et al. 2023

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The ability to enhance fracture healing is paramount in modern orthopaedic trauma, particularly in the management of challenging cases including peri-prosthetic fractures, non-union and acute bone loss. Materials utilised in enhancing fracture healing should ideally be osteogenic, osteoinductive, osteoconductive, and facilitate vascular in-growth. Autologous bone graft remains the gold standard, providing all of these qualities. Limitations to this technique include low graft volume and donor site morbidity, with alternative techniques including the use of allograft or xenograft. Artificial scaffolds can provide an osteoconductive construct, however fail to provide an osteoinductive stimulus, and frequently have poor mechanical properties. Recombinant bone morphogenetic proteins can provide an osteoinductive stimulus; however, their licencing is limited and larger studies are required to clarify their role. For recalcitricant non-unions or high-risk cases, the use of composite graft combining the above techniques provides the highest chances of successfully achieving bony union.

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Section: Synthetic Bone Substitutesmentioning

confidence: 99%

Section: Synthetic Bone Substitutesmentioning

confidence: 99%