Bioactive Goniothalamin from <i>Goniothalamus tapis</i> with Cytotoxic Potential

Abstract

Goniothalamus (Annonaceae) is well known for the rich of styryllactone contents and these plants are famous for the potential to be applied as alternative biological activities. The chemical and biological investigations of Goniothalamus tapis is tested for anticancer activities. The research was processioned to extract, isolate, purify and elucidate structure from the leaves and twigs of G. tapis. The isolated compound was evaluated with cytotoxic activity. Goniothalamin was isolated from ethyl acetate extract of G. tapis and the spectroscopic techniques were used for structure elucidation. In addition, goniothalamin was the most powerful to cytotoxic activity which was the first reported for this specie. The goniothalamin was possessed a potent cytotoxicity. Therefore, it is possible to use this compound as a pharmacological agent.

Cytotoxic compounds from Goniothalamus repevensis Pierre ex Finet & Gagnep

“…Various Goniothalamus species are known to produce structurally diverse metabolites, comprising acetogenins [4][5][6][7][8][9][10], styryl lactones [11][12][13][14][15][16][17], alkaloids [14,[16][17][18][19], and flavonoids [20]. Several acetogenins and styryl lactones exhibited potent cytotoxic activity against various cancerous cell lines [21].…”

Review: Traditional knowledge of the Dayak Tribes (Borneo) in the use of medicinal plants

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