Bioactive Ingredients Obtained from Agro-industrial Byproducts: Recent Advances and Innovation in Micro- and Nanoencapsulation

Rossi, Yanina; Braber, Noelia Luciana Vanden; Vergara, Ladislao Díaz; Montenegro, Mariana

doi:10.1021/acs.jafc.1c05447

Cited by 12 publications

(15 citation statements)

References 62 publications

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“…After being placed into a centrifuge tube, the sample was spun at 5000 rpm for 30 min to test centrifugal stability. 14 To study the freeze−thaw stability of the samples, ME and CIA-ME were placed for three cycles (24 h) at 4°C and 40 °C to evaluate the appearance of phase separation. Photos of the microscopic morphology of the sample were taken using a JEM-2100 transmission electron microscope (TEM) (JEOL Ltd., Japan).…”

Section: ■ Methodsmentioning

confidence: 99%

“…The pH was measured with a digital pH meter (Mettler Toledo, Switzerland) at RT. After being placed into a centrifuge tube, the sample was spun at 5000 rpm for 30 min to test centrifugal stability . To study the freeze–thaw stability of the samples, ME and CIA-ME were placed for three cycles (24 h) at 4°C and 40 °C to evaluate the appearance of phase separation.…”

Section: Methodsmentioning

confidence: 99%

“…Typically, effective delivery of bioactive ingredients into food products is crucial. 13,14 However, generating a stable formulation of CO and CE is challenging due to the complex ingredients and difficulty in dissolving in water or oils. Moreover, essential oils are unstable in the presence of light, heat, moisture, air, and metals, which may result in the loss of characteristic aroma and cause irritation to the skin.…”

Section: ■ Introductionmentioning

confidence: 99%

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Sustainable Use of Chrysanthemum indicum var. aromaticum as Value-Added Green Materials in Microemulsion Hydrogels

Feng

et al. 2023

ACS Sustainable Chem. Eng.

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The essential oil extracted from the flowers of Chrysanthemum indicum var. aromaticum (CIA) has excellent biological properties; however, the stems and leaves of CIA often get wasted. Maximizing the use of these wastes will help solve the sustainability issues of CIA resources. The present study analyzed the chemical compositions of CIA flower essential oil (CO) and stem and leaf extract (CE) by gas chromatography–mass spectrometry (GC–MS) and ultra-performance liquid chromatography–mass spectrometry (UPLC-MS). Then, the phytochemical properties, stability, antioxidant capacity, and cell (human L929) toxicity of CO and CE were further evaluated. Finally, oil-in-water microemulsion (ME) and hyaluronic acid hydrogel systems composed of CO and CE were developed to deliver bioactive ingredients effectively. The analysis identified 64 and 31 compounds in CO and CE, respectively, and indicated them as readily available sources of natural antioxidants, such as flavonoids and phenols. In addition, the formulation of the ME system (CIA-ME) improved CO stability and increased CE loading; these optimal formulations (ME, CIA-ME, CIA-ME gel) exhibited good stability, rheological properties, and sustained release properties without causing cell toxicity and skin irritation. The CIA-ME significantly inhibited intracellular tyrosinase activity and decreased intracellular melanin production in a dose-dependent manner. It also demonstrated skin photoprotection and inhibited tyrosinase, collagenase, and elastase activities. Overall, CIA as a plant raw material can serve as a promising topical cosmetic or medicine prototype. Applying CO and CE in combination provides a basis for the sustainable utilization of CIA resources.

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Section: ■ Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: ■ Introductionmentioning

confidence: 99%

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Sustainable Use of Chrysanthemum indicum var. aromaticum as Value-Added Green Materials in Microemulsion Hydrogels

Feng

et al. 2023

ACS Sustainable Chem. Eng.

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“…It has been mentioned that liposome embedding probiotics and prebiotics and other substances can help active substances reach the gut safely to achieve colonization and improve their activity and function (Sarao & Arora, 2017). At present, liposomes are used to protect probiotics in food to reach the intestine (Rossi et al., 2021). For example, Bifidobacterium and Lactobacillus have been encapsulated in liposomes and applied to dairy products and other beverage products to help alleviate gastrointestinal environmental problems.…”

Section: Release Of the Liposomal Core Materials In The Gutmentioning

confidence: 99%

Specific surface modification of liposomes for gut targeting of food bioactive agents

Zhang

Pan

et al. 2023

Comp Rev Food Sci Food Safe

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Liposomes have become a research hotspot in recent years as food delivery systems with attractive properties, including the bilayer structure assembled like the cell membrane, reducing the side‐effect and improving environmental stability of cargos, controlling release, extending duration of functional ingredients, and high biodegradable and biocompatible abilities in the body. However, the conventional liposomes lack stability during storage and are weak in targeted absorption in the gastrointestinal track. At present, surface modification has been approved to be an effective platform to shield these barricades and help liposomes deliver the agents safely and effectively to the ideal site. In this review, the gastrointestinal stability of conventional liposomes, cargo release models from liposomes, and the biological fate of the core materials after release were emphasized. Then, the strategies in both physical and chemical perspectives to improve the stability and utilization of liposomes in the gastrointestinal tract, and the emerging approaches for improving gut targeting by specifically modified liposomes and the intestinal receptors relative to liposomes/cargos absorption were highlighted. Last but not the least, the safety, challenges, and opportunities for the improvement of liposomal bioavailability were also discussed to inspire new applications of liposomes as oral carriers.

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“…These fish by-products, especially fish skins, are a good source of collagen or gelatin and are widely used in the food, cosmetic, and biomedical industries. They are also the raw materials for the production of bioactive peptides or protein hydrolysates, which can be used as functional food ingredients [ 12 , 13 ]. Although processing protein hydrolysates into powders is a common procedure, to our knowledge, limited research has been undertaken on developing drying strategies to balance the preparation process, functionality, and bioactivity of hydrolysates [ 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of Spray Drying and Freeze Drying on Physicochemical Properties, Antioxidant and ACE Inhibitory Activities of Bighead Carp (Aristichthys nobilis) Skin Hydrolysates

Dong

Yan

Zhang

2022

Foods

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The physicochemical, structural properties, antioxidant, and angiotensin I-converting enzyme (ACE) inhibitory activities of fish skin protein hydrolysate (SPH) that were freeze-dried (SPH-FD) and spray-dried (SPH-SD) were investigated. SPH-SD showed abundant volatile compounds, higher DPPH radical scavenging activity and ferrous iron chelating activity than SPH-FD, while the ABTS radical scavenging activity and ACE inhibitory activity were not influenced by the drying method. Amino acid compositions showed a higher proportion of proline and hydroxyproline residues in SPH-FD. The major molecular weights were both distributed below 1000 Da. SPH-SD had spherical structures, while SPH-FD had glass shard-like structures. The results indicated that the drying method could affect the physicochemical properties of hydrolysates, and SPH-SD showed potential prospects in developing functional fortified foods.

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Bioactive Ingredients Obtained from Agro-industrial Byproducts: Recent Advances and Innovation in Micro- and Nanoencapsulation

Cited by 12 publications

References 62 publications

Sustainable Use of Chrysanthemum indicum var. aromaticum as Value-Added Green Materials in Microemulsion Hydrogels

Sustainable Use of Chrysanthemum indicum var. aromaticum as Value-Added Green Materials in Microemulsion Hydrogels

Specific surface modification of liposomes for gut targeting of food bioactive agents

Effects of Spray Drying and Freeze Drying on Physicochemical Properties, Antioxidant and ACE Inhibitory Activities of Bighead Carp (Aristichthys nobilis) Skin Hydrolysates

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