Bioactive leads for skin aging—Current scenario and future perspectives

Nema, Neelesh K.; Chaudhary, Sushil K.; Kar, Amit; Bahadur, Shiv; Harwansh, Ranjit K.; Haldar, Pallab Kanti; Sharma, Nanaocha; Mukherjee, Pulok Kumar

doi:10.1016/b978-0-323-85542-6.00020-2

Cited by 3 publications

(1 citation statement)

References 137 publications

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“…Most of the previous studies clinically proved the anti-aging effect of Bosewellia serrata resin extracts and its main components; the pentacyclic triterpene boswellic acids [ 38 , 39 ]. Despite the increasing interest in frankincense oil as one of the most important commercial essential oils available in the international market, becoming increasingly popular for promoting skin health [ 15 , 40 ], its anti-aging effect is still unclear.…”

Section: Introductionmentioning

confidence: 99%

Protective potential of frankincense essential oil and its loaded solid lipid nanoparticles against UVB-induced photodamage in rats via MAPK and PI3K/AKT signaling pathways; A promising anti-aging therapy

Kotb,

El-Shiekh,

Abd-Elsalam

et al. 2023

PLoS ONE

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Frankincense oil has gained increased popularity in skin care, yet its anti-aging effect remains unclear. The current study aimed to investigate the anti-photoaging effect of frankincense (Boswellia papyrifera (Del.) Hochst., Family Burseraceae) essential oil in an in vivo model. The oil was initially extracted by two methods: hydro-distillation (HD) and microwave-assisted hydro-distillation (MAHD). GC/MS analysis revealed the dominance of n-octyl acetate, along with other marker compounds of B. papyrifera including octanol and diterpene components (verticilla 4(20) 7, 11-triene and incensole acetate). Thereafter, preliminary investigation of the anti-collagenase and anti-elastase activities of the extracted oils revealed the superior anti-aging effect of HD-extracted oil (FO), comparable to epigallocatechin gallate. FO was subsequently formulated into solid lipid nanoparticles (FO-SLNs) via high shear homogenization to improve its solubility and skin penetration characteristics prior to in vivo testing. The optimimal formulation prepared with 0.5% FO, and 4% Tween® 80, demonstrated nanosized spherical particles with high entrapment efficiency percentage and sustained release for 8 hours. The anti-photoaging effect of FO and FO-SLNs was then evaluated in UVB-irradiated hairless rats, compared to Vitamin A palmitate as a positive standard. FO and FO-SLNs restored the antioxidant capacity (SOD and CAT) and prohibited inflammatory markers (IL6, NFκB p65) in UVB-irradiated rats via downregulation of MAPK (pERK, pJNK, and pp38) and PI3K/AKT signaling pathways, alongside upregulating TGF-β expression. Subsequently, our treatments induced Procollagen I synthesis and downregulation of MMPs (MMP1, MMP9), where FO-SLNs exhibited superior anti-photoaging effect, compared to FO and Vitamin A, highlighting the use of SLNs as a promising nanocarrier for FO. In particular, FO-SLNs revealed normal epidermal and dermal histological structures, protected against UVβ-induced epidermal thickness and dermal collagen degradation. Our results indicated the potential use of FO-SLNs as a promising topical anti-aging therapy.

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Section: Introductionmentioning

confidence: 99%

Protective potential of frankincense essential oil and its loaded solid lipid nanoparticles against UVB-induced photodamage in rats via MAPK and PI3K/AKT signaling pathways; A promising anti-aging therapy

Kotb,

El-Shiekh,

Abd-Elsalam

et al. 2023

PLoS ONE

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A novel quercetin-phospholipid complex gel for enhanced skin permeability and photoprotection - Ex vivo and in vivo studies

Rana,

Harwansh,

Deshmukh

2025

Journal of Drug Delivery Science and Technology

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Recent Insight into UV-induced Oxidative Stress and Role of Herbal Bioactives in the Management of Skin Aging

Harwansh

Deshmukh

2024

CPB

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Skin is a defensive barrier that protects the body against sun rays and other harmful environmental elements. Sun rays contain ultraviolet rays, UVA (320-400 nm) and UVB (280-320 nm), which are highly harmful to the skin, leading to photoaging. Nowadays, sunscreen products are being utilized to protect the skin against photodamage. Conventional sunscreens are useful but cannot provide skin protection against UV rays for a longer period of time. Therefore, they need to be applied frequently. Aromatic compounds (ACs)-based sunscreens may filter out the UV rays but give rise to several side effects, like premature aging, stress, atopic dermatitis, keratinocytes (KCs) damage, genetic interruption, and malignant melanoma due to deposition of their toxic metabolites on the skin. The concept of natural medicines has become popular worldwide because of their safety and efficacy. Natural medicines have been proven to possess a wide array of biological properties, including antioxidant, antityrosinase, antielastase, antiwrinkle, antiaging, anti-inflammatory, anticancer, etc., against sun rays-mediated skin damage. The present review article is focused on UV-induced oxidative stress, and pathological and molecular targets with updates on herbal bioactives for the management of skin aging.

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Bioactive leads for skin aging—Current scenario and future perspectives

Cited by 3 publications

References 137 publications

Protective potential of frankincense essential oil and its loaded solid lipid nanoparticles against UVB-induced photodamage in rats via MAPK and PI3K/AKT signaling pathways; A promising anti-aging therapy

Protective potential of frankincense essential oil and its loaded solid lipid nanoparticles against UVB-induced photodamage in rats via MAPK and PI3K/AKT signaling pathways; A promising anti-aging therapy

A novel quercetin-phospholipid complex gel for enhanced skin permeability and photoprotection - Ex vivo and in vivo studies

Recent Insight into UV-induced Oxidative Stress and Role of Herbal Bioactives in the Management of Skin Aging

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