Bioactive lipid regulation of platelet function, hemostasis, and thrombosis

One-Year Effects of High-Intensity Statin on Bioactive Lipids: Findings From the JUPITER Trial

“…[10][11][12] BALs are a diverse group of lipid-signaling molecules that act through interactions with specific receptors or directly affect cellular processes, with versatile and bioactive roles in various biological functions. [13][14][15][16] These biomolecules are involved in proinflammatory and anti-inflammatory responses and inflammation resolution, 15,16 hemostasis and platelet aggregation activity, 17 endothelial integrity and vascular permeability, 18 control of vascular tone, 19 and diabetogenic pathways. 20 We hypothesized that randomized statin treatment favorably alters levels of BALs and other lipid features with cardioprotective properties compared with placebo, helping to elucidate the spectrum of pleiotropic effects of statins.…”

“…BALs are a diverse group of lipid-signaling molecules that act through interactions with specific receptors or directly affect cellular processes, with versatile and bioactive roles in various biological functions. 13–16 These biomolecules are involved in proinflammatory and anti-inflammatory responses and inflammation resolution, 15,16 hemostasis and platelet aggregation activity, 17 endothelial integrity and vascular permeability, 18 control of vascular tone, 19 and diabetogenic pathways. 20…”