2023
DOI: 10.3389/fimmu.2023.1031968
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Bioactive lipids as biomarkers of adverse reactions associated with apheresis platelet concentrate transfusion

Abstract: Platelet concentrate (PC) transfusion seeks to provide haemostasis in patients presenting severe central thrombocytopenia or severe bleeding. PCs may induce adverse reactions (AR) that can occasionally be severe (SAR). PCs contain active biomolecules such as cytokines and lipid mediators. The processing and storage of PCs creates so-called structural and biochemical storage lesions that accumulate when blood products reach their shelf life. We sought to investigate lipid mediators as bioactive molecules of int… Show more

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Cited by 6 publications
(1 citation statement)
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“…As a consequence, platelet concentrates accumulate BRMs during processing and storage, and these BRMs are ultimately transfused alongside platelets and can induce immune responses and posttransfusion reactions in the transfusion recipient. [30][31][32] This hypothesis and other mechanisms related to endothelial injury and microthrombi formation need to be explored relative to how platelets are manufactured to include storage temperature.…”
Section: Methodsmentioning
confidence: 99%
“…As a consequence, platelet concentrates accumulate BRMs during processing and storage, and these BRMs are ultimately transfused alongside platelets and can induce immune responses and posttransfusion reactions in the transfusion recipient. [30][31][32] This hypothesis and other mechanisms related to endothelial injury and microthrombi formation need to be explored relative to how platelets are manufactured to include storage temperature.…”
Section: Methodsmentioning
confidence: 99%