Bioactive, luminescent erbium-doped hydroxyapatite nanocrystals for biomedical applications

Nguyen, Van Tu; Park, Sumin; Choi, Jaeyeop; Tran, Le Hai; Yi, Myunggi; Shin, Joong Ho; Lee, Chang-Yong; Oh, Junghwan

doi:10.1016/j.ceramint.2020.03.152

Cited by 30 publications

(5 citation statements)

References 44 publications

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“…Crystallinity is reduced with increasing concentrations of the element [ 82 ]. On the other hand, A- and B-type substitutions have been reported [ 82 , 83 ]. Under 400 nm light irradiation, Er-HAp exhibits emissions associated with purple, blue and green colors ( 4 F 3/2 → 4 I 15/2 , 4 F 7/2 → 4 I 15/2 , and 4 S 3/2 → 4 I 15/2 transitions, respectively) [ 83 ].…”

Section: Impact Of Lanthanide Incorporation On the Morphology And Pro...mentioning

confidence: 99%

Lanthanides-Substituted Hydroxyapatite for Biomedical Applications

Lama-Odría

Valle

Puiggalı́

2023

IJMS

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Lately, there has been an increasing demand for materials that could improve tissue regenerative therapies and provide antimicrobial effects. Similarly, there is a growing need to develop or modify biomaterials for the diagnosis and treatment of different pathologies. In this scenario, hydroxyapatite (HAp) appears as a bioceramic with extended functionalities. Nevertheless, there are certain disadvantages related to the mechanical properties and lack of antimicrobial capacity. To circumvent them, the doping of HAp with a variety of cationic ions is emerging as a good alterative due to the different biological roles of each ion. Among many elements, lanthanides are understudied despite their great potential in the biomedical field. For this reason, the present review focuses on the biological benefits of lanthanides and how their incorporation into HAp can alter its morphology and physical properties. A comprehensive section of the applications of lanthanides-substituted HAp nanoparticles (HAp NPs) is presented to unveil the potential biomedical uses of these systems. Finally, the need to study the tolerable and non-toxic percentages of substitution with these elements is highlighted.

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Section: Impact Of Lanthanide Incorporation On the Morphology And Pro...mentioning

confidence: 99%

Lanthanides-Substituted Hydroxyapatite for Biomedical Applications

Lama-Odría

Valle

Puiggalı́

2023

IJMS

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“…The thermal treatment (600 °C) and 2% Eu 3+ doping content were optimized for fabricating nanocrystalline Eu-doped HAp (20–40 nm in diameter) with strong luminescence. In another study, luminescent erbium (Er 3+ ) ions at different concentrations (0.1, 0.25, 0.5, and 1.0 mol%) were added to HAp nanocrystals (Er-HAp) to develop a nontoxic luminescent agent for biomedical imaging applications [ 128 ]. The results showed that 1.0 mol% Er-doped HAp nanocrystals (<50 nm size distribution) had high-efficiency light emission after being excited at 400 nm ( Figure 4 ).…”

Section: Doped Hap Nps For Cancer Theranosticsmentioning

confidence: 99%

Hydroxyapatite Nanoparticles for Improved Cancer Theranostics

Kargozar

Mollazadeh

Kermani

et al. 2022

JFB

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Beyond their well-known applications in bone tissue engineering, hydroxyapatite nanoparticles (HAp NPs) have also been showing great promise for improved cancer therapy. The chemical structure of HAp NPs offers excellent possibilities for loading and delivering a broad range of anticancer drugs in a sustained, prolonged, and targeted manner and thus eliciting lower complications than conventional chemotherapeutic strategies. The incorporation of specific therapeutic elements into the basic composition of HAp NPs is another approach, alone or synergistically with drug release, to provide advanced anticancer effects such as the capability to inhibit the growth and metastasis of cancer cells through activating specific cell signaling pathways. HAp NPs can be easily converted to smart anticancer agents by applying different surface modification treatments to facilitate the targeting and killing of cancer cells without significant adverse effects on normal healthy cells. The applications in cancer diagnosis for magnetic and nuclear in vivo imaging are also promising as the detection of solid tumor cells is now achievable by utilizing superparamagnetic HAp NPs. The ongoing research emphasizes the use of HAp NPs in fabricating three-dimensional scaffolds for the treatment of cancerous tissues or organs, promoting the regeneration of healthy tissue after cancer detection and removal. This review provides a summary of HAp NP applications in cancer theranostics, highlighting the current limitations and the challenges ahead for this field to open new avenues for research.

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“…The results also show Er-doped FAP samples have higher emissions than Er-doped HAPs. 24,26 In addition, the emission peaks' sharpness indicates a clearer color. Especially in powder samples, the color purity of 76% is much better than the values found for similar phosphors in the literature.…”

Section: Photoluminescence Properties-figuresmentioning

confidence: 99%

“…22 Therefore, natural fluorapatite is a potential candidate for its wider band gap (∼5.44 eV). 20 In the literature, Er-doped HAP nanoparticles have been extensively studied for NIR, 23 biomedical, 24,25 and biosensor 26 applications. On the other hand, FAP has been investigated for in-vitro biomedical imaging due to its near-infrared emission, generally with Er/Yb co-doped.…”

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confidence: 99%

Synthesis and Characterization of Luminescent Er³⁺-Doped Natural Fluorapatite

Demir¹,

Karacaoğlu²,

Ayas³

2022

ECS J. Solid State Sci. Technol.

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Ca10(PO4)6F2:xEr3+ (x = 0.1, 0.3 and 0.5) was synthesized using solid-state powder process (1150°C, 1h), conventional sintering (1150°C, 1h), and spark plasma sintering (SPS) techniques (1150°C, 10 min, and 50 MPa). X-ray diffraction analysis revealed that all samples are generally composed of fluorapatite (FAP) containing quartz as a minor phase, and the presence of Er2O3 peaks is becoming more evident as Er-doped increases. In the scanning electron microscopy microstructure images, non-diffused Er2O3 particles also increase with powder and pellet samples doping. However, the PL analysis showed that the luminescence intensity did not increase proportionally with the doping content caused by the concentration quenching effect. FAP samples doped with 0.3 mol Er have higher luminescence intensity than 0.1 and 0.5 mol Er-doped samples. In addition, powder samples have the highest luminescence intensity due to increased luminescence intensity with increasing crystallite size. The characteristic 2H11/2 to 4I15/2 emission bands of Er3+ at ~530 nm are seen in all samples. The maximum average lifetime was obtained in 125 µs in the powder sample with 0.3 mol Er. CIE color coordinates demonstrate the standard green color under ~275 nm excitation; eventually, these phosphors can be utilized as green phosphors for optical applications.

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Bioactive, luminescent erbium-doped hydroxyapatite nanocrystals for biomedical applications

Cited by 30 publications

References 44 publications

Lanthanides-Substituted Hydroxyapatite for Biomedical Applications

Lanthanides-Substituted Hydroxyapatite for Biomedical Applications

Hydroxyapatite Nanoparticles for Improved Cancer Theranostics

Synthesis and Characterization of Luminescent Er³⁺-Doped Natural Fluorapatite

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Bioactive, luminescent erbium-doped hydroxyapatite nanocrystals for biomedical applications

Cited by 30 publications

References 44 publications

Lanthanides-Substituted Hydroxyapatite for Biomedical Applications

Lanthanides-Substituted Hydroxyapatite for Biomedical Applications

Hydroxyapatite Nanoparticles for Improved Cancer Theranostics

Synthesis and Characterization of Luminescent Er3+-Doped Natural Fluorapatite

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Synthesis and Characterization of Luminescent Er³⁺-Doped Natural Fluorapatite