Bioactive Lupane and Hopane Triterpenes from Lepisanthes senegalensis

Lomchid, Pornwimon; Nasomjai, Pitak; Kanokmedhakul, Somdej; Boonmak, Jaursup; Youngme, Sujittra; Kanokmedhakul, Kwanjai

doi:10.1055/s-0042-116438

Cited by 9 publications

(22 citation statements)

References 20 publications

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“…and has also been used to cure infection and diarrhoea in some regions of Guizhou Province, China. It is a prolific source of natural hopane triterpenoids which exhibit cytotoxicity and antiproliferative activity [6,7]. The bond lengths and angles derived from the title structure are within normal ranges.…”

Section: Commentmentioning

confidence: 99%

Crystal structure of (4S,4aS,6aR,6bR,12aS,12bR,14aS,14bR)-3,3,6a,6b,9,9,12a-heptamethyloctadecahydro-1H,3H-4,14b-ethanophenanthro[1,2-h]isochromene, C₃₀H₅₀O

Fan

et al. 2018

Zeitschrift Für Kristallographie - New Crystal Structures

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Section: Commentmentioning

confidence: 99%

Crystal structure of (4S,4aS,6aR,6bR,12aS,12bR,14aS,14bR)-3,3,6a,6b,9,9,12a-heptamethyloctadecahydro-1H,3H-4,14b-ethanophenanthro[1,2-h]isochromene, C₃₀H₅₀O

Fan

et al. 2018

Zeitschrift Für Kristallographie - New Crystal Structures

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“…The rest of compounds belong to this category, which have different skeletons and sometimes attached to sugar ring like glucose, galactopyranosyl and hexoseside-pentoside (90-96) (Figure 8). 46 3-O-trans-caffeoylbetulin L. senegalensis (st & r) 46 3-O-trans -caffeoylbetulinic acid L. senegalensis (st) 46 Betulin L. senegalensis (st) 46 Betulinic acid L. senegalensis (st) 46 Lupeol L. senegalensis (st & r) 46 3-O-trans -caffeoyllupeol L. senegalensis (r) 46 3-O-α-ʟ-arabinopyranosyl hederagenin L. rubiginosa (b) 47 3-O-α-ʟ-rhamnopyranosyl(1-2)-α-ʟ-arabinopyranosyl hederagenin L. rubiginosa (b) 47 3…”

Section: Other Compoundsmentioning

confidence: 99%

Phytochemistry and Pharmacological Activities of Lepisanthes Genus: A Review

2021

TJNPR

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The genus Lepisanthes belonging to Sapindaceae family, comprises of 26 species and 2 subspecies of trees and shrubs. 1 They are widely distributed in tropical region from Africa to Madagascar, South to Southeast Asia and from northwestern Australia to New Guinea. The distribution of plants according to species are summarized in Table 1. The trees of Lepisanthes genus are commonly found in a coastal forest or on islands, or in the transition zone between mangrove and dry land. It can also grow in lowland forest, wastelands, by streams, or in secondary forest up to 500 m altitude. Plants from the genus Lepisanthes are discriminated based on their micro-morphological characters such as cuticular striation, stomata structure, type of waxes, trichome 2 as well as vessels, parenchyma, rays and fiber morphology. 3 Traditionally, plants from this genus are used to cure headache, fever, 4 chest pain and nosebleed. 5 Aside from medicinal uses, it is also utilized as food preservatives and as sleep-inducing food. 6 The timbers are used for house building, manufactured as tool handles, crafted as kitchen utensil and chopped as firewood. 7 Unripe fruits are green in color and when the fruits are ripe, the color change from yellow to orange to red. Some species are planted for their fruits. [8][9][10] Due to its colorful fruits, Lepisanthes alata is used as decorative plant among local in Malaysia. 11 The fruits are 3 to 4 cm long obovoid berries borne in clusters, and can be eaten fresh, as it is sweet when ripe. This species is widely planted due to the sweetness of the fruits. The phytochemical screening of this genus has shown the presence of alkaloids, flavonoids, tannins, saponin triterpenoids, phenolics and glycosides. 6,[12][13] Pharmacological studies of the extracts showed the presence of anticancer, antimicrobial, antiacetylcholinesterase,

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“…Structures of the triterpenoid pyracrenic acid (3β-O-trans-caffeoyl betulinic acid, 3) and betulinic acid (3b) isolated from the Lao plant, Diospyros quaesita, and of selected derivatives 3a and 3c-3g. Lomchid et al (2017), Ma et al (2008), andShi et al (2014). 1 (Kim et al, 2010), 2 (Shi et al, 2014), 3 (Pan et al, 2008), and 4 (Ma et al, 2008).…”

Section: Ebenaceae (Diospyros Quaesita Thw)mentioning

confidence: 99%

Bioactive small-molecule constituents of Lao plants

Ren¹,

Bethany²,

Joshua³

et al. 2021

J. Med. Plants Res.

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Laos has a rich plant diversity, and medicinal plants are used extensively in Lao traditional medicine for the treatment of a variety of human diseases. However, only a relatively small number of these plants have been investigated for their major components with potential antitumor, anti-infective, and other types of bioactivities. These species include Asparagus cochinchinensis, Diospyros quaesita, Gongronema napalense, Marsypopetalum modestum, Nauclea orientalis, Rourea minor, Stemona pierrei, and Stemona tuberosa. Thus far, the bioactive compounds isolated from these Lao plants include alkaloids, glycerol esters, phenolic compounds such as lignans and stilbenoids, steroids, and triterpenoids. Of these, the norlignan, nyasol (1b), the triterpenes, pyracrenic acid [3β-O-transcaffeoylbetulinic acid (3)] and betulinic acid (3b), and the dimeric thiopyridine, dipyrithione (5), were found to show both cancer cell cytotoxicity and anti-infective activity. The present review focuses on examples of promising lead compounds isolated from Lao plants, with their possible development as potential therapeutic agents being discussed. It is hoped that this contribution will provide useful information on higher plants growing in Laos to help stimulate future discoveries of potential agents for the treatment of cancer, infections, and other diseases.

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Bioactive Lupane and Hopane Triterpenes from Lepisanthes senegalensis

Cited by 9 publications

References 20 publications

Crystal structure of (4S,4aS,6aR,6bR,12aS,12bR,14aS,14bR)-3,3,6a,6b,9,9,12a-heptamethyloctadecahydro-1H,3H-4,14b-ethanophenanthro[1,2-h]isochromene, C₃₀H₅₀O

Crystal structure of (4S,4aS,6aR,6bR,12aS,12bR,14aS,14bR)-3,3,6a,6b,9,9,12a-heptamethyloctadecahydro-1H,3H-4,14b-ethanophenanthro[1,2-h]isochromene, C₃₀H₅₀O

Phytochemistry and Pharmacological Activities of Lepisanthes Genus: A Review

Bioactive small-molecule constituents of Lao plants

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Bioactive Lupane and Hopane Triterpenes from Lepisanthes senegalensis

Cited by 9 publications

References 20 publications

Crystal structure of (4S,4aS,6aR,6bR,12aS,12bR,14aS,14bR)-3,3,6a,6b,9,9,12a-heptamethyloctadecahydro-1H,3H-4,14b-ethanophenanthro[1,2-h]isochromene, C30H50O

Crystal structure of (4S,4aS,6aR,6bR,12aS,12bR,14aS,14bR)-3,3,6a,6b,9,9,12a-heptamethyloctadecahydro-1H,3H-4,14b-ethanophenanthro[1,2-h]isochromene, C30H50O

Phytochemistry and Pharmacological Activities of Lepisanthes Genus: A Review

Bioactive small-molecule constituents of Lao plants

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Product

Resources

About

Crystal structure of (4S,4aS,6aR,6bR,12aS,12bR,14aS,14bR)-3,3,6a,6b,9,9,12a-heptamethyloctadecahydro-1H,3H-4,14b-ethanophenanthro[1,2-h]isochromene, C₃₀H₅₀O

Crystal structure of (4S,4aS,6aR,6bR,12aS,12bR,14aS,14bR)-3,3,6a,6b,9,9,12a-heptamethyloctadecahydro-1H,3H-4,14b-ethanophenanthro[1,2-h]isochromene, C₃₀H₅₀O