Bioactive Marine Molecules and Derivatives with Biopharmaceutical Potential

Schroeder, G.; Bates, Stephen S.; Barre, Stéphane

doi:10.1002/9783527801718.ch19

Cited by 5 publications

(9 citation statements)

References 94 publications

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“…Where required, low resolution ESI tandem MS was performed on a Bruker amaZon SL ion trap via syringe infusion or by injection into a constant flow stream with a rheodyne valve and an Alltech HPLC pump (mobile phase methanol, flow rate 0.3 mL min -1 ) connected to an Apollo II ESI MTP ion source in positive ion mode. Tandem mass spectra of the [M+H] + parent ion were obtained manually up to MS 5 (depending on sensitivity). Spectra were acquired in positive ion mode using a 1–4 Da isolation window, with the excitation amplitude manually optimized for each spectrum to have the selected mass at ~10% of the height of the largest fragment.…”

Section: Experimental Methodsmentioning

confidence: 99%

“…Marine ecosystems have long been a rich source of bioactive natural products, in the search for interesting molecules and novel therapeutic agents. 1–5 Many interesting and structurally diverse secondary metabolites have been isolated from marine sources and characterised over the last 70 years. 6–9 Yet the first ‘drugs from the sea’ were only approved in the early 2000s: the cone snail peptide ziconotide (ω-conotoxin MVIIA) in 2004 to alleviate chronic pain, 10 and sea squirt metabolite trabectedin in 2007 for treatment of soft-tissue sarcoma.…”

Section: Introductionmentioning

confidence: 99%

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Discovery of antimicrobial compounds from Lendenfeldia, Ircinia and Dysidea sponges using bioassay guided fractionation of marine extracts

Dinarvand

Proschogo

Spain

et al. 2018

Preprint

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Multidrug resistant bacteria have emerged as a threat to public health all over the world. At the same time, the discovery of new bioactive small molecules with antimicrobial activity and suitable pharmacological properties has waned. Herein we report the screening of marine extracts to identify novel compounds with antimicrobial activity. Bioassay guided fractionation has enabled the discovery and identification of a family of simple amines with promising activity against methicillin resistant Staphylococcus aureus (MRSA). To confirm the natural product structures proposed, these compounds and analogues have been prepared synthetically. Several of the synthetic analogues showed promising bioactivity against the medically important pathogens MRSA (MICs to 12.5 µM), Mycobacterium tuberculosis (MICs to 0.02 µM), uropathogenic Escherichia coli (MIC 6.2 µM) and Pseudomonas aeruginosa (MIC 3.1 µM). Cross-referencing antimicrobial activity and toxicity show that these synthetic compounds display a favourable therapeutic index for their target pathogens.

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Section: Experimental Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Discovery of antimicrobial compounds from Lendenfeldia, Ircinia and Dysidea sponges using bioassay guided fractionation of marine extracts

Dinarvand

Proschogo

Spain

et al. 2018

Preprint

View full text Add to dashboard Cite

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“…Nevertheless, these enzymes are not enough to respond to the new technological challenges that appear each day [157]. [158]. The market for industrial enzymes is growing every year and the exploitation of extremozymes is a huge and mostly unexplored resource [159].…”

Section: Biotechnological Applications Of Piezophilesmentioning

confidence: 99%

“…Additionally, many piezophilic bacteria contain omega 3-PUFAs associated with their cell membrane, which are precursors to hormones and hormonelike molecules in many animals. Consequently, it could be used for hypertriglyceridemia diseases and clinical studies for this purpose have already been approved [158].…”

Section: Biotechnological Applications Of Piezophilesmentioning

confidence: 99%

High-pressure adaptation of extremophiles and biotechnological applications

Salvador-Castell

Oger

Peters

2020

Physiological and Biotechnological Aspects of Extremophiles

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During the last decades, high pressure has been an important physical parameter not only to study biomolecules, but also for its biotechnological applications. High pressure affects organism's ability to survive by altering most of cell's macromolecules. These effects can be used, for example, to inactivate microorganisms, enhance enzymatic reactions or to modulate cell activities. Moreover, some organisms are capable to growth under high pressures thanks to their adaptation at all cellular levels. Such adaptation confers a wide range of potentially interesting macromolecules still to be discovered. In this chapter, we firstly present the different effects of pressure on cells and the diverse strategies used to cope against this harsh environment. Secondly, we explored the pressure biotechnological applications on pressure-sensitive and adaptedpressure organisms.

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“…1 Marine ecosystems have long been a rich source of bioactive natural products in the search for interesting molecules and novel therapeutic agents. 2–6 Many interesting and structurally diverse secondary metabolites have been isolated from marine sources over the last 70 years. 7–10 In addition, the preclinical pharmacology of seventy-five compounds isolated from marine organisms have been reported to have biological activities.…”

Section: Introductionmentioning

confidence: 99%

Identification bioactive compounds from marine microorganism and exploration of structure–activity relationships (SARs)

Dinarvand

2020

Preprint

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Marine natural products (MNPs) have become new strong leads for antimicrobial drug discovery and an effective alternative to control drug resistant infections. Herein we report the bioassay guided fractionation of marine extracts from sponges Lendenfeldia, Ircinia and Dysidea that led us to identify novel compounds with antimicrobial properties. Tertiary amines or quaternary amine salts: anilines 1, benzylamines 2, tertiary amines 3 and 4, and quaternary amine salt 5, along with three known compounds (6-8) were isolated from a crude extract and MeOH eluent marine extracts. The absolute configurations of the new compounds were assigned based on tandem mass spectrometry (MS) analysis. Several of the compounds exhibited potent in-vitro antibacterial activity, especially against Methicillin-resistant Staphylococcus aureus (MRSA) (MICs from 15.6 to 62.5 micro g/mL). Herein, we also, report structure activity relationships of a diverse range of commercial structurally similar compounds. The structure activity relationships (SARs) results clearly demonstrate that modification of the amines through linear chain length, and inclusion of aromatic rings, modifies the observed antimicrobial activity towards different biological activity. Several commercially available compounds, which are structurally related to the molecules we discovered showed broad spectrum antimicrobial activity against different test pathogens with an MIC50 range of 50 to 0.01 micro M. The results of cross-referencing antimicrobial activity and cytotoxicity establish that these compounds are promising potential lead molecules, with a favourable therapeutic index for antimicrobial drug development. Additionally, the SAR studies show that simplified analogues of the isolated compounds with increased bioactivity

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Bioactive Marine Molecules and Derivatives with Biopharmaceutical Potential

Cited by 5 publications

References 94 publications

Discovery of antimicrobial compounds from Lendenfeldia, Ircinia and Dysidea sponges using bioassay guided fractionation of marine extracts

Discovery of antimicrobial compounds from Lendenfeldia, Ircinia and Dysidea sponges using bioassay guided fractionation of marine extracts

High-pressure adaptation of extremophiles and biotechnological applications

Identification bioactive compounds from marine microorganism and exploration of structure–activity relationships (SARs)

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