Bioactive Mixed Ligand Metal Complexes Of Cu(II), Ni(II), And Zn(II) Ions: Synthesis, Characterization, Antimicrobial And Antioxidant Properties

Zahan, Md. Kudrat-E; Camellia, Farzana Khanm; Mahmud, Abdullah Al; Pramanik, Md. Joy; Nahar, Kamrun; Haque, M. M.

doi:10.4067/s0717-97072021000305295

Cited by 16 publications

(6 citation statements)

References 26 publications

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“…According to the findings, all of the metal complexes showed moderate DPPH radical scavenging activity (Figs. [13][14]. The order can be expressed as BHT> CuL1> NiL1> ZnL1>L1.…”

Section: Antioxidant Activitymentioning

confidence: 99%

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Synthesis, Characterization, Antibacterial and Antioxidant Studies of Isoniazid-based Schiff Base Ligands and Their Metal Complexes

Camellia

Ashrafuzzaman

Islam

et al. 2022

AJACR

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The condensation of aromatic aldehyde with amine results in the formation of Schiff's bases, which are considered to be one of the most significant groups of ligands. Schiff's base metal complexes have received a lot of attention because of their high biological activity. Such include antimicrobial, anticancer, antibacterial, and antifungal activities. The current research is focused on the synthesis and characterization of two Schiff's base ligands obtained from the reaction of isoniazid with 4-(N,N-dimethylamino)benzaldehyde (L1) and 5-nitro-2-furfurldehyde (L2), respectively and their metal complexes with Cu2+, Zn2+, and Ni2+ ions. FT-IR, UV-Vis, conductivity, and magnetic susceptibility (µeff) measurements were used to describe the ligands (L1 and L2) and their complexes. The square planar geometry of Cu2+ and Ni2+ complexes, as well as the tetrahedral geometry of Zn2+ complexes, are supported by the Uv-Vis spectra and magnetic moments data. Their antibacterial effectiveness against various pathogenic microorganisms was evaluated in the presence of standard Kanamycin-30. The CuL2 complex, among all the metal complexes derived from the L2 ligand, exhibited better antibacterial activity against S. aureus than that of Kanamycin-30. When compared to the BHT antioxidant, all Cu2+ complexes showed excellent efficacy.

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“…According to the findings, all of the metal complexes showed moderate DPPH radical scavenging activity (Figs. [13][14]. The order can be expressed as BHT> CuL1> NiL1> ZnL1>L1.…”

Section: Antioxidant Activitymentioning

confidence: 99%

“…It is well known that metal complexes obtained from isoniazid-based Schiff bases exhibit greater antibacterial activity than isoniazid as well as free ligands. The anti-oxidant action of the Schiff base is further improved when it is coordinated with transition metal ions [14].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization, Antibacterial and Antioxidant Studies of Isoniazid-based Schiff Base Ligands and Their Metal Complexes

Camellia

Ashrafuzzaman

Islam

et al. 2022

AJACR

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“…This focus stems from the recognition that oxidative stress and the detrimental effects caused by free radicals play a role in various pathological conditions such as cancer, cardiovascular diseases, neurodegenerative disorders, and the aging process. [11,12] The evaluation of the antioxidant potential of metal complexes derived from Schiff bases entails investigating their capacity to scavenge free radicals, inhibit oxidative reactions, and shield biomolecules from oxidative damage. These assessments commonly employ various in vitro assays, including the DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging, ABTS (2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid)) radical cation decolorization, superoxide radical scavenging, lipid peroxidation inhibition, and DNA damage protection assays.…”

Section: Introductionmentioning

confidence: 99%

“…In recent years, significant research efforts have been devoted to assessing the antioxidant capabilities of these metal complexes. This focus stems from the recognition that oxidative stress and the detrimental effects caused by free radicals play a role in various pathological conditions such as cancer, cardiovascular diseases, neurodegenerative disorders, and the aging process [11,12] …”

Section: Introductionmentioning

confidence: 99%

Antioxidant Activity and DFT Calculations of Metal Complexes Derived from a Schiff Base Ligand: Synthesis, Characterization, and Biological Evaluation

Lawan,

Mshelia,

Mala

et al. 2024

ChemistrySelect

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Metal complexes derived from Schiff bases are known to have a wide range of applications, spanning the areas of material and medicinal sciences. Herein, a Schiff base ligand, (Z)‐2‐(((4‐chlorophenyl)imino)methyl)naphthalen‐1‐ol HL, was synthesized via a condensation reaction between 2‐hydroxy‐1‐naphthaldehyde and 4‐chloroaniline using methanol as a solvent in the presence of a catalytic amount of formic acid. The obtained ligand was further reacted with Mn(II), Ni(II), and Cu(II) using their acetate salts in a 1 : 2 stoichiometric ratio of metal to ligand to afford complexes C1–C3, respectively. Physicochemical and analytical techniques consisting of FTIR, UV‐Vis, elemental (CHN and metal content), TGA, HRMS, 1H, and 13 C NMR spectroscopy were deployed to establish the formation of the compounds. Results show that the ligand coordinated with the metal ions through the oxygen and nitrogen atoms of the phenolate and azomethine moieties, respectively, forming ON‐type complexes. Furthermore, the free ligand and its complexes were evaluated for their antioxidant activity compared to the standard (ascorbic acid) using an in vitro DPPH radical scavenging assay. From this investigation, C1 demonstrated higher radical scavenging activity than the free ligand, the complexes, and the standard (ascorbic acid). But the ligand has better scavenging activity than C2 and C3 at higher concentrations. DFT was also used to examine the electronic properties of the compounds, and the data obtained corroborated well with the experimental study.

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“…Many mixed ligand-complexes of transition metals have demonstrated a wide range of biological properties. These biologically important metal ions and their mixed ligand complexes have also been linked to the activation of several enzymes [ 12 ], transportation of active molecules through membrane and storage [ 13 ]. It was extensively reported that transition metal mixed ligand complexes are employed in treating microbial infections because they are shown to be more biologically active than the ligand alone and its binary complexes [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Computational Drug Designing, Synthesis, Characterization and Anti-bacterial Activity Evaluation of Some Mixed Ligand–Metal Complexes of 2-hydroxybenzaldehydethiosemicarbazone as Primary Ligand

Khan¹,

Zehra²,

Fatima³

et al. 2023

Chemistry Africa

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This paper reports the mixed ligand–metal complexes of CuSO 4 ·5H 2 O and ZnSO 4 ·7H 2 O with salicylaldehyde thiosemicarbazone (2-hydroxybenzaldehyde thiosemicarbazone) as primary ligand and imidazole (im), pyridine (py) and triphenylphosphine (PPh 3 ) as secondary ligands through a general preparatory route. The ligand and complexes were characterized by FTIR, UV, 1 H-NMR and molar conductance techniques. Computational studies to know the physicochemical parameters, bioactivity scores, absorption, distribution, metabolism, excretion and toxicity (ADMET) properties were carried out through Molinspiration, SwissADME and admetSAR softwares. Molecular docking was perfomed with M pro of SARS-CoV-2 (PDB i.d.6LU7), Aspartate Kinase (PDB i.d.5YEI) and Transforming Growth Factor β (PDB i.d. 3KFD) using PyRx automated docking software. The antibacterial activity was tested using Agar well method. Computational findings revealed that almost all the complexes had clogP values less than 5 indicating their bioavailability. The bioactivity scores of the complexes were between moderate to good. The mixed ligand complexes having imidazole as secondary ligand displayed relatively high FCsp 3 , indicating their potential as lead candidates. [Zn(C 8 H 9 N 3 OS)(PPh 3 ) 2 (SO 4 )] and [Cu(C 8 H 9 N 3 OS)(im) 2 (SO 4 )] exhibited appreciable binding affinity against the selected proteins. Furthermore, the molecular simulation findings with the ligated [Cu(C 8 H 9 N 3 OS)(im) 2 (SO 4 )] and aspartate kinase showed compact folding, less deviations and significant stability. The stability of the ligand was further confirmed by the frontier molecular orbitals (FMOs) gap. The energy gap (− 0.423 eV) indicated molecular stability. The ligand was active against L. monocytogenes, S. aureus and E.coli having zone of inhibition of 11, 11 and 10 mm respectively. Among the complexes, [Cu(C 8 H 9 N 3 OS)(im) 2 (SO 4 )] had the minimum inhibitory concentrations (MIC) ranging between 32 and 128 µg/mL against the selecetd bacterial strains. Graphical Abstract Supplementary Information The online version contains supplementary material available at 10.1007/s42250-023-00640-4.

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Bioactive Mixed Ligand Metal Complexes Of Cu(II), Ni(II), And Zn(II) Ions: Synthesis, Characterization, Antimicrobial And Antioxidant Properties

Cited by 16 publications

References 26 publications

Synthesis, Characterization, Antibacterial and Antioxidant Studies of Isoniazid-based Schiff Base Ligands and Their Metal Complexes

Synthesis, Characterization, Antibacterial and Antioxidant Studies of Isoniazid-based Schiff Base Ligands and Their Metal Complexes

Antioxidant Activity and DFT Calculations of Metal Complexes Derived from a Schiff Base Ligand: Synthesis, Characterization, and Biological Evaluation

Computational Drug Designing, Synthesis, Characterization and Anti-bacterial Activity Evaluation of Some Mixed Ligand–Metal Complexes of 2-hydroxybenzaldehydethiosemicarbazone as Primary Ligand

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