Bioactive moist bionanocellulose-based wound dressing material

Guzdek-Zając, Katarzyna; Krajcer, Aleksandra; Lewandowska-Łańcucka, Joanna; Nowakowska, Maria

doi:10.1016/j.apsusc.2020.146108

Cited by 7 publications

(3 citation statements)

References 47 publications

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“…During the first 72 hours of the experiment, weight gain was noted, and it was caused by swelling of the materials under employed conditions. A similar phenomenon of the initial increase in sample mass was presented by Guzdek–Zając et al 34 However, in the latter stage of the degradation study the remaining weight of all developed materials slowly decreased. After 168 hours of the degradation, a decreasing trend in mass was noticed for all samples in comparison to the initial hours of the experiment (no statistical significance).…”

Section: Resultssupporting

confidence: 82%

Innovative Vancomycin-Loaded Hydrogel-Based Systems – New Opportunities for the Antibiotic Therapy

Florczyk,

Krajcer,

Wójcik

et al. 2024

IJN

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Purpose Surgical site infections pose a significant challenge for medical services. Systemic antibiotics may be insufficient in preventing bacterial biofilm development. With the local administration of antibiotics, it is easier to minimize possible complications, achieve drugs’ higher concentration at the injured site, as well as provide their more sustained release. Therefore, the main objective of the proposed herein studies was the fabrication and characterization of innovative hydrogel-based composites for local vancomycin (VAN) therapy. Methods Presented systems are composed of ionically gelled chitosan particles loaded with vancomycin, embedded into biomimetic collagen/chitosan/hyaluronic acid-based hydrogels crosslinked with genipin and freeze-dried to serve in a flake/disc-like form. VAN-loaded carriers were characterized for their size, stability, and encapsulation efficiency (EE) using dynamic light scattering technique, zeta potential measurements, and UV–Vis spectroscopy, respectively. The synthesized composites were tested in terms of their physicochemical and biological features. Results Spherical structures with sizes of about 200 nm and encapsulation efficiencies reaching values of approximately 60% were obtained. It was found that the resulting particles exhibit stability over time. The antibacterial activity of the developed materials against Staphylococcus aureus was established. Moreover, in vitro cell culture study revealed that the surfaces of all prepared systems are biocompatible as they supported the proliferation and adhesion of the model MG-63 cells. In addition, we have demonstrated significantly prolonged VAN release while minimizing the initial burst effect for the composites compared to bare nanoparticles and verified their desired physicochemical features during swellability, and degradation experiments. Conclusion It is expected that the developed herein system will enable direct delivery of the antibiotic at an exposed to infections surgical site, providing drugs sustained release and thus will reduce the risk of systemic toxicity. This strategy would both inhibit biofilm formation and accelerate the healing process.

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Section: Resultssupporting

confidence: 82%

Innovative Vancomycin-Loaded Hydrogel-Based Systems – New Opportunities for the Antibiotic Therapy

Florczyk,

Krajcer,

Wójcik

et al. 2024

IJN

Self Cite

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“…As matrix of wound dressings, some important physicchemical characteristics, such as water absorption and retention, water vapor transmission rate (WVTR), should be measured because a moist environment can promote the penetration of the active substances, protect wounds against bacterial invasion, and provide a painless removal from wound surface after recovery. [31] An ideal wound dressing should lock the exudates, as well as maintain proper wound moisture during the healing process. Therefore, the FK-SA sponge and FK/SA composite were measured as followings.…”

Section: Resultsmentioning

confidence: 99%

A Flexible and Moisturizing Multilayer Microporous Sponge Copolymerized with Keratin and Alginate

Dai

Zhang

et al. 2021

ChemistrySelect

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Feather keratin (FK), a kind of low-cost natural biopolymer with strong mechanical properties, was pretreated by sodium hydroxide solution, and then reacted with N-hydroxy succinimide (NHS) coupled sodium alginate (SA) (SA-NHS), which afforded multilayer microporous materials (FK-SA sponge) of keratin combining alginate, and its performance as wound dressing was measured. Its structure and properties were characterized by Fourier-Transform infrared spectroscopy (FT-IR), thermogravimetric analysis/differential scanning calorimetry (TG/ DSC), scanning electron microscopy (SEM), absorption capacity, water retention and water vapor transmittance. The antimicrobial properties and release behavior were also studied. Under the condition of pH 7.4, the cumulative release rate of model drug-loaded FK-SA sponge got to 74 % within 13 hrs. Meanwhile, FK-SA sponge supported benzalkonium chloride, a typical broad-spectrum bactericide, has excellent antibacterial activity and unique biodegradability. That means this multilayer microporous sponge is expected to be used as wound dressing in the clinical nursing field and continuous drug delivery carrier in the biomedical field.

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“…Based on the extraction method and resultant morphology, cellulose fibres are classified into cellulose nanocrystals (CNCs) and cellulose micro- and nanofibres (CMFs and CNFs, respectively). The CNC has a needle-like morphology with dimensions of 4–20 nm in width and 100–500 nm in length, a highly crystalline structure, and a high mechanical stiffness [ 16 ]. In contrast, CMF and CNF have both amorphous and crystalline regions in their structures, with long and flexible chains up to several micrometres in length.…”

Section: Introductionmentioning

confidence: 99%

The Potential of Sugarcane Waste-Derived Cellulose Fibres as Haemostatic Agents

Malone,

Yegappan,

Kijas

et al. 2024

Polymers

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Haemorrhage control during surgery and following traumatic injury remains a critical, life-saving challenge. Cellulose products are already employed in commercially available haemostatic dressings. This work explores sourcing cellulose from sugarcane trash pulp to produce micro- and nanosized fibres with hydroxyl, carboxylic acid, and trimethylamine functional groups, resulting in either positive or negative surface charges. This paper assesses the influence of these fibres on multiple blood clotting parameters in both dispersed solutions and dry gauze applications. In vitro blood clotting studies demonstrated the significant haemostatic potential of cellulose fibres derived from sugarcane waste to initiate clotting. Plasma absorbance assays showed that the 0.25 mg/mL cellulose microfibre dispersion had the highest clotting performance. It was observed that no single property of surface charge, functionality, or fibre morphology exclusively controlled the clotting initiation measured. Instead, a combination of these factors affected clot formation, with negatively charged cellulose microfibres comprising hydroxyl surface groups providing the most promising result, accelerating the coagulation cascade mechanism by 67% compared to the endogenous activity. This difference in clot initiation shows the potential for the non-wood agricultural waste source of cellulose in haemostatic wound healing applications, contributing to the broader understanding of cellulose-based materials’ versatility and their applications in biomedicine.

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Bioactive moist bionanocellulose-based wound dressing material

Cited by 7 publications

References 47 publications

Innovative Vancomycin-Loaded Hydrogel-Based Systems – New Opportunities for the Antibiotic Therapy

Innovative Vancomycin-Loaded Hydrogel-Based Systems – New Opportunities for the Antibiotic Therapy

A Flexible and Moisturizing Multilayer Microporous Sponge Copolymerized with Keratin and Alginate

The Potential of Sugarcane Waste-Derived Cellulose Fibres as Haemostatic Agents

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