Bioactive molecule encapsulation on metal-organic framework via simple mechanochemical method for controlled topical drug delivery systems

Noorian, Seyyed Abbas; Hemmatinejad, Nahid; Navarro, Jorge A. R.

doi:10.1016/j.micromeso.2020.110199

Cited by 48 publications

(24 citation statements)

References 31 publications

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“…It is a solvent-free, green, and economical drug loading technique, mechanically mixing drug powder and MOFs together in solid status. Drugs such as 5-FU, caffeine, p-aminobenzoic acid and benzocaine were caged into MOFs by grinding method, reaching high drug loading amount and sustained release 196 .…”

Section: Drug Loading and Characterizationsmentioning

confidence: 99%

Metal-organic frameworks for advanced drug delivery

et al. 2021

Acta Pharmaceutica Sinica B

292

116

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Metal-organic frameworks (MOFs), comprised of organic ligands and metal ions/metal clusters via coordinative bonds are highly porous, crystalline materials. Their tunable porosity, chemical composition, size and shape, and easy surface functionalization make this large family more and more popular for drug delivery. There is a growing interest over the last decades in the design of engineered MOFs with controlled sizes for a variety of biomedical applications. This article presents an overall review and perspectives of MOFs-based drug delivery systems (DDSs), starting with the MOFs classification adapted for DDSs based on the types of constituting metals and ligands. Then, the synthesis and characterization of MOFs for DDSs are developed, followed by the drug loading strategies, applications, biopharmaceutics and quality control. Importantly, a variety of representative applications of MOFs are detailed from a point of view of applications in pharmaceutics, diseases therapy and advanced DDSs. In particular, the biopharmaceutics and quality control of MOFs-based DDSs are summarized with critical issues to be addressed. Finally, challenges in MOFs development for DDSs are discussed, such as biostability, biosafety, biopharmaceutics and nomenclature.

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Section: Drug Loading and Characterizationsmentioning

confidence: 99%

Metal-organic frameworks for advanced drug delivery

et al. 2021

Acta Pharmaceutica Sinica B

292

116

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“…The structure of MOFs will gradually decompose under certain external stimulus conditions to release the drug and realize the sustained drug release. Hemmatinejad’s group used a ball-milling technique to effectively encapsulate the model drugs 5-fluorouracil, caffeine, para -aminobenzoic acid, and benzocaine in [Zn 4 O(3,5-dimethyl-4-carboxypyrazolato) 3 ] MOFs([Zn 4 O(dmcapz) 3 ]). And the controlled release of active pharmaceutical substances from [Zn 4 O(dmcapz) 3 ] was studied under simulated human physiological conditions, which proved its applicability as a local drug delivery system.…”

Section: Methods and Types Of Synthesized Micro/nano Reactorsmentioning

confidence: 99%

“…The structure of MOFs will gradually decompose under certain external stimulus conditions to release the drug and realize the sustained drug release. Hemmatinejad's group 47 human physiological conditions, which proved its applicability as a local drug delivery system. In Tan's work, 48 manual grinding and automatic vortex grinding were used to synthesize the anticancer drug 5-fluorouracil@MIL-100 (Figure 5c) and proved the feasibility of the simple solvent-free one-pot strategy.…”

Section: Coprecipitationmentioning

confidence: 99%

The Encounter of Biomolecules in Metal–Organic Framework Micro/Nano Reactors

Zhang

Jin

et al. 2021

ACS Appl. Mater. Interfaces

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In nature, biochemical reactions often take place in confined spaces, as typically exemplified by cells. As numerous cellular reactors can be integrated to maintain the living system, researchers have made constant efforts to construct cell-like structures for achieving similar transformations in vitro. Micro/nano reactors engineered by polymers and colloids are becoming popular and being applied in many fields, especially there has been an increasing trend toward constructing metal–organic framework (MOF) micro/nano reactors with the thriving of MOF nanotechnologies. Because of the uniform pores of MOFs, the transmission of substances can be regulated more accurately. Along with properties of large specific surface area, functional diversity and precise control of the particle size, MOFs are also ideal platforms for building distinct microenvironments for biological substances. Compared with traditional polymersomes and colloidosomes, the unique characteristics of MOFs render them potent micro/nano reactor shell materials, mimicking cells for applications in enzymatic catalysis, sensing, nanotherapy, vaccine, biodegradation, etc. This review highlights recent signs of progress on the design of MOF micro/nano reactors and their applications in biology, discusses the existing problems, and prospects their promising properties for smarter multifunctional applications.

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“…Structurally diverse carriers such as gels, liposomes, micropores, foams and lms have Loading [MathJax]/jax/output/CommonHTML/fonts/TeX/fontdata.js been introduced for DDSs, the most signi cant advantages of which are including the improved therapeutic effect, reduced toxicity, etc. [6][7][8][9][10][11][12][13][14][15]. The controlled drug release is the process through which a carrier such as polymeric, metal, protein or lipid nanoparticles is purposefully combined with the active drug to release it in the body in a predetermined and desired manner.…”

Section: Introductionmentioning

confidence: 99%

Controlled Release 7-Methoxytacrine-Polycaprolactone Nanocapsules Drug-Delivery System for Alzheimer's Disease Treatment: Synthesis and Physico-Chemical Characterization

et al. 2021

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Alzheimer's disease is the most prevalent cause of dementia in aging people. 7-Methoxytacrine (7-MEOTA) is one of the approved drugs for the treatment of this disease. In the current study, a 7-MEOTA delivery system has been prepared based on the polycaprolactone nanocapsules (7-MEOTA@PCL) and its physico-chemical properties were investigated as well. The drug amount loaded in nanocapsules has been estimated 65%. The average particle size of the 7-MEOTA@PCL nanocapsules was around 237 nm with polydispersity index of 0.31 and negative surface charge (-21.2 mV). The prepared nanoparticles are stable upon 40 days storage at 25 °C, without any decomposition. The morphological analysis of the 7-MEOTA@PCL nanoparticles indicated that the nanoparticles are spherical, and free of any aggregation. In vitro release experiments revealed controlled release of the 7-MEOTA from the polycaprolactone nanocapsules. Application of the Korsmeyer-Peppas model to the release kinetics data showed that the release of the drug was by diffusion Fick's law.

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Bioactive molecule encapsulation on metal-organic framework via simple mechanochemical method for controlled topical drug delivery systems

Cited by 48 publications

References 31 publications

Metal-organic frameworks for advanced drug delivery

Metal-organic frameworks for advanced drug delivery

The Encounter of Biomolecules in Metal–Organic Framework Micro/Nano Reactors

Controlled Release 7-Methoxytacrine-Polycaprolactone Nanocapsules Drug-Delivery System for Alzheimer's Disease Treatment: Synthesis and Physico-Chemical Characterization

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