Bioactive molecules from<i>Nocardia</i>: diversity, bioactivities and biosynthesis

Dhakal, Dipesh; Rayamajhi, Vijay; Mishra, Rajneesh Kumar; Sohng, Jae Kyung

doi:10.1007/s10295-018-02120-y

Cited by 43 publications

(31 citation statements)

References 160 publications

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“…AD domain sequences associated with the non-Streptomyces actinobacteria, showed a prevalent distribution (>50% of relative abundance) in some samples: e.g., Mycobacterium in sample 87 and Nocardia in sample 72 (Table S5). Nocardia strains are also very rich producers of bioactive NPs [67] and have been previously isolated in Antarctic studies [68], but, to our knowledge, no compounds have been reported from Antarctic Nocardia strains (Table S5).…”

Section: Taxonomic Identity Of Nrps Genesmentioning

confidence: 99%

Diversity of Bacterial Biosynthetic Genes in Maritime Antarctica

et al. 2020

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Bacterial natural products (NPs) are still a major source of new drug leads. Polyketides (PKs) and non-ribosomal peptides (NRP) are two pharmaceutically important families of NPs and recent studies have revealed Antarctica to harbor endemic polyketide synthase (PKS) and non-ribosomal peptide synthetase (NRPS) genes, likely to be involved in the production of novel metabolites. Despite this, the diversity of secondary metabolites genes in Antarctica is still poorly explored. In this study, a computational bioprospection approach was employed to study the diversity and identity of PKS and NRPS genes to one of the most biodiverse areas in maritime Antarctica-Maxwell Bay. Amplicon sequencing of soil samples targeting ketosynthase (KS) and adenylation (AD) domains of PKS and NRPS genes, respectively, revealed abundant and unexplored chemical diversity in this peninsula. About 20% of AD domain sequences were only distantly related to characterized biosynthetic genes. Several PKS and NRPS genes were found to be closely associated to recently described metabolites including those from uncultured and candidate phyla. The combination of new approaches in computational biology and new culture-dependent and -independent strategies is thus critical for the recovery of the potential novel chemistry encoded in Antarctica microorganisms. target the highly conserved ketosynthase (KS) and adenylation (AD) domains of PKS and NRPS genes, respectively. A growing number of studies have employed the PCR-based sequence tag approach to uncover PKS and NRPS gene diversity across different environmental microbiomes [7][8][9].Extreme environments, such as Antarctica, have the potential to reveal novel molecules since they are still a poorly explored source of chemical scaffolds and novel chemical diversity [10,11]. As such, metabarcoding approaches to study PKS and NRPS diversity in Antarctic ecosystems represent a simple and effective strategy to understand the biosynthetic potential of a large number of sampling sites [7]. A couple of such studies have been carried out very recently in Antarctica [12,13] revealing that soils at different Antarctica locations harbor multiple endemic PKS and NRPS genes, likely to be involved in the synthesis of new chemical diversity. In Antarctic soils, the percentage of yet-uncultured genera is expected to be much higher [14] than the 82% described for general soils [15]. A considerable fraction of such uncultured bacteria corresponds to members of the NP-rich Actinobacteria [16,17] and Cyanobacteria [18,19] phyla.King George Island is one of the largest ice-free and biodiverse areas in maritime Antarctica [20]. It harbors a high density of scientific stations, particularly in Maxwell Bay [21], where most of terrestrial biology research takes place. Although bacterial diversity studies have been conducted in this area [22,23], the diversity of bacterial biosynthetic genes has not been a target of study. Here, we perform a detailed study on soil samples from Maxwell Bay, with the main goal of assessing the...

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Section: Taxonomic Identity Of Nrps Genesmentioning

confidence: 99%

Diversity of Bacterial Biosynthetic Genes in Maritime Antarctica

et al. 2020

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“…These bacteria have been shown to produce structurally diverse NPs with potent bioactivities. [29][30][31][32][33] The antimicrobials from Nocardia spp. and bacteriocins from Staphylococcus spp.…”

Section: Scope Of the Reviewmentioning

confidence: 99%

“…and bacteriocins from Staphylococcus spp. have been summarized in recent reviews, 25,33 and thus those NPs with remarkable activities from these bacteria were highlighted. Finally, we provide a thorough compilation of the antimicrobial NPs from bacterial pathogens, Burkholderia spp., C. puniceum, Dickeya spp., E. amylovora, Nocardia spp., Photorhabdus spp., P. larvae, Pseudomonas spp., Staphylococcus spp., S. marcescens, S. mutans, Streptomyces spp., Vibrio spp., Xanthomonas spp., Xenorhabdus spp., and Yersinia ruckeri (see Table S1 in the ESI † of this article listed in alphabetical order).…”

Section: Scope Of the Reviewmentioning

confidence: 99%

Bacterial pathogens: threat or treat (a review on bioactive natural products from bacterial pathogens)

Maglangit

Deng

2021

Nat. Prod. Rep.

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“…In this review, the bacteria causing respiratory tract infections are introduced, and in the next step, the experimental methods used to recognize the cause of infections are explained. (31)(32)(33) On standard laboratory media, after incubation at 35-37°C for several days, they develop as heaped, irregular, and waxy colonies.…”

Section: Infection Epidemiology and Microbiologymentioning

confidence: 99%

A Review on Bacterial Respiratory Infections and Optimization of Their Identification

Mirhoseini

Heydari

Abednezhad

et al. 2020

IEM

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Background: The current narrative review aims to describe microbial agents causing pneumonia briefly. In addition, the ongoing review tries to introduce the diagnostic methods from biochemical to molecular tests used routinely and the promising molecular methods which will be used in near future. Materials & Methods: PubMed was searched for all review and original articles related to the lung infection. Studies providing insights into clinical symptoms, microbiology, risk factors, and diagnosis were included. Conclusion: Untreated respiratory infections are one of the most common health care problems worldwide. We tried to provide a collective view of new aspects of bacteriology and diagnosis methodology of lung infection detection.

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Bioactive molecules fromNocardia: diversity, bioactivities and biosynthesis

Cited by 43 publications

References 160 publications

Diversity of Bacterial Biosynthetic Genes in Maritime Antarctica

Diversity of Bacterial Biosynthetic Genes in Maritime Antarctica

Bacterial pathogens: threat or treat (a review on bioactive natural products from bacterial pathogens)

A Review on Bacterial Respiratory Infections and Optimization of Their Identification

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