Bioactive nanocarbon assemblies: Nanoarchitectonics and applications

Nakanishi, Waka; Minami, Kosuke; Shrestha, Lok Kumar; Ji, Qingmin; Hill, Jonathan P.

doi:10.1016/j.nantod.2014.05.002

Cited by 245 publications

(119 citation statements)

References 106 publications

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“…[17] Nakanishi et al have summarised the biological applications, especially cell growth, sensing, and control using nanoarchitectures of nanocarbons. [18] Wang et al [19] proposed that nanodiamondÀepirubicin drug delivery complex is capable of killing chemoresistant cancer stem cells and preventing secondary tumour formation in liver cancer. It has been noticed that compound naphthalocyanine encapsulated in water soluble polymer dendrimer can be used to kill the tumour and cancer cells in ovarian cancer.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, characterisation and antimicrobial activity of manganese- and iron-doped zinc oxide nanoparticles

Sharma

Jandaik

Kumar

et al. 2015

Journal of Experimental Nanoscience

111

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The present work reports study on antimicrobial activity of pure and doped ZnO nanocomposites. Polyvinyl pyrrolidone capped Mn-and Fe-doped ZnO nanocomposites were synthesised using simple chemical co-precipitation technique. The synthesised materials were characterised using transmission electron microscope (TEM), X-ray powder diffraction (XRD), energy dispersive X-ray fluorescence (EDXRF), Fourier transform infrared (FTIR) spectroscopy and ultraviolet (UV) visible spectroscopy. The XRD and TEM studies reveal that the synthesised ZnO nanocrystals have a hexagonal wurtzite structure with average crystalline size »7À14 nm. EDXRF and FTIR study confirmed the doping and the incorporation of impurity in ZnO nanostructure. The antimicrobial activities of nanoparticles (NPs) were studied against fungi, grampositive and gram-negative bacteria using the standard disc diffusion method. The photocatalytic activities of prepared NPs were evaluated by degradation of methylene blue dye in aqueous solution under UV light irradiation. Experimental results demonstrated that ZnO NPs doped with 10% of Mn and Fe ions showed maximum antimicrobial and photodegradation efficiency in contrast with that of the 1% loading. The enhancement in antimicrobial effect and photocatalytic degradation is attributed to the generation of reactive oxygen species due to the synergistic effects of Mn and Fe loading.

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Section: Introductionmentioning

confidence: 99%

Synthesis, characterisation and antimicrobial activity of manganese- and iron-doped zinc oxide nanoparticles

Sharma

Jandaik

Kumar

et al. 2015

Journal of Experimental Nanoscience

111

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show abstract

“…Such dispersing approaches facilitate the bottom-up formation of highly ordered structures resulting in fascinating synergies, affording additional functions useful for a large number of applications ranging from sensing, catalysis, drug delivery and to tissue engineering. [11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30] In this regard, the use of de novo peptides, whose sequence, length, structure and assembly can be conveniently tailored, is an efficient and elegant route for the preparation of stable CNT dispersions, [31][32][33][34][35][36] as well as for the directed incorporation of CNT building blocks into hierarchical structures 31,[37][38][39][40] and functional devices. [41][42][43] In particular, peptide-functionalized nanomaterials are increasingly playing an important role in tissue and biomedical engineering for the development of novel synthetic scaffolds for cell culture in vitro that closely resemble in vivo conditions and show improved biomimetic properties.…”

Section: Introductionmentioning

confidence: 99%

Multifunctional, biocompatible and pH-responsive carbon nanotube- and graphene oxide/tectomer hybrid composites and coatings

et al. 2017

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“…[5][6][7] Many new types of nanocarriers have been developed to optimize solid tumor therapy. [8][9][10][11][12] However, traditional nanocarriers generally cannot effectively overcome the physiological barriers of the solid tumor itself; thus, the major nanocarriers often simply distribute around the tumor vessels. [13][14][15] The tumor extravascular barrier, which is composed of tumor extracellular matrix (ECM) and multiple layers of tumor cells (MLTC), represents the most formidable barrier.…”

Section: Introductionmentioning

confidence: 99%

A functional nanocarrier that copenetrates extracellular matrix and multiple layers of tumor cells for sequential and deep tumor autophagy inhibitor and chemotherapeutic delivery

et al. 2016

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To further enhance the intensity of deep tumor drug delivery and integrate a combined therapy, we herein report on a core-shell nanocarrier that could simultaneously overcome the double barriers of the extracellular matrix (ECM) and multiple layers of tumor cells (MLTC). A pH-triggered reversible swelling-shrinking core and an MMP2 (matrix metallopeptidase 2) degradable shell were developed to encapsulate chemotherapeutics and macroautophagy/autophagy inhibitors, respectively. MMP2 degraded the shell, which was followed by the autophagy inhibitors' release. The exposed core could diffuse along the pore within the ECM to deliver chemotherapeutics into deep tumors, and it was able to swell in lysosomes and shrink back in the cytoplasm or ECM. The swelling of the core resulted in the rapid release of chemotherapeutics to kill autophagy-inhibited cells. After leaving the dead cells, the shrinking core could act on neighboring cells that were closer to the center of the tumor. The core thus could also cross MLTC layer by layer to deliver chemotherapeutics into the deep tumor.

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Bioactive nanocarbon assemblies: Nanoarchitectonics and applications

Cited by 245 publications

References 106 publications

Synthesis, characterisation and antimicrobial activity of manganese- and iron-doped zinc oxide nanoparticles

Synthesis, characterisation and antimicrobial activity of manganese- and iron-doped zinc oxide nanoparticles

Multifunctional, biocompatible and pH-responsive carbon nanotube- and graphene oxide/tectomer hybrid composites and coatings

A functional nanocarrier that copenetrates extracellular matrix and multiple layers of tumor cells for sequential and deep tumor autophagy inhibitor and chemotherapeutic delivery

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