Bioactive natural compounds against human coronaviruses: a review and perspective

Xian, Yan‐Fang; Zhang, Juan; Bian, Zhaoxiang; Zhou, Hua; Zhang, Zhenbiao; Lin, Zhi‐Xiu; Hong, Xu

doi:10.1016/j.apsb.2020.06.002

Cited by 155 publications

(118 citation statements)

References 109 publications

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“…Their ability to disrupt the life cycle of SARS-CoV-2 is partially achieved via interference with viral proteins. For example, among our top-ranked molecules, epigallocatechin 3-gallate was demonstrated experimentally to inhibit 3-chymotrypsin-like protease (3CLpro) [ 38 ]; quercetin demonstrated binding affinity to inhibit 3CLpro and papain-like protease (PLpro) [ 40 ], while trans-resveratrol inhibits nucleocapsid (N) proteins [ 18 ].…”

Section: Resultsmentioning

confidence: 99%

“…Investigating the influence of a single drug or food component on any particular viral infection takes months to years of experimental research. Examples of experimentally derived phytochemicals with antiviral properties include hesperedin and naringin in citrus foods, tannic acid in black tea, emodin in rhubarb and myristicin in dill and parsley [ 17 , 18 ]. Given the vast molecular space, the traditional practicalities of investigating the influence of a single molecule or food component would take far too long to have an impact on the current COVID-19 crisis.…”

Section: Introductionmentioning

confidence: 99%

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Network machine learning maps phytochemically rich “Hyperfoods” to fight COVID-19

et al. 2021

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In this paper, we introduce a network machine learning method to identify potential bioactive anti-COVID-19 molecules in foods based on their capacity to target the SARS-CoV-2-host gene-gene (protein-protein) interactome. Our analyses were performed using a supercomputing DreamLab App platform, harnessing the idle computational power of thousands of smartphones. Machine learning models were initially calibrated by demonstrating that the proposed method can predict anti-COVID-19 candidates among experimental and clinically approved drugs (5658 in total) targeting COVID-19 interactomics with the balanced classification accuracy of 80–85% in 5-fold cross-validated settings. This identified the most promising drug candidates that can be potentially “repurposed” against COVID-19 including common drugs used to combat cardiovascular and metabolic disorders, such as simvastatin, atorvastatin and metformin. A database of 7694 bioactive food-based molecules was run through the calibrated machine learning algorithm, which identified 52 biologically active molecules, from varied chemical classes, including flavonoids, terpenoids, coumarins and indoles predicted to target SARS-CoV-2-host interactome networks. This in turn was used to construct a “food map” with the theoretical anti-COVID-19 potential of each ingredient estimated based on the diversity and relative levels of candidate compounds with antiviral properties. We expect this in silico predicted food map to play an important role in future clinical studies of precision nutrition interventions against COVID-19 and other viral diseases.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Network machine learning maps phytochemically rich “Hyperfoods” to fight COVID-19

et al. 2021

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“…PLpro is not only responsible for processing viral polyproteins, but is also involved in deubiquitination (cleaving ubiquitin chains) and deISGylation, which represent relevant factors in the host immune response to viruses (Cho et al 2013 ). By removing ubiquitin and ISG15 proteins from host cell proteins, the innate host immune response is likely to be compromised (Ratia et al 2014 ; Xian et al 2020 ). PLpro of both SARS- and MERS-CoV has been shown to possess deubiquitinating activities (Park et al 2017 ).…”

Section: Major Targets Of Flavonoids Against Covsmentioning

confidence: 99%

Flavonoids: A complementary approach to conventional therapy of COVID-19?

2020

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COVID-19, the highly contagious novel disease caused by SARS-CoV-2, has become a major international concern as it has spread quickly all over the globe. However, scientific knowledge and therapeutic treatment options for this new coronavirus remain limited. Although previous outbreaks of human coronaviruses (CoVs) such as SARS and MERS stimulated research, there are, to date, no antiviral therapeutics available that specifically target these kinds of viruses. Natural compounds with a great diversity of chemical structures may provide an alternative approach for the discovery of new antivirals. In fact, numerous flavonoids were found to have antiviral effects against SARS-and MERS-CoV by mainly inhibiting the enzymes 3-chymotrypsin-like protease (3CLpro) and papain-like protease (PLpro). In this review, we specifically focused on the search for flavonoids, polyphenolic compounds, which are proven to be effective against human CoVs. We therefore summarized and analyzed the latest progress in research to identify flavonoids for antiviral therapy and proposed strategies for future work on medicinal plants against coronaviruses such as SARS-CoV-2. We discovered quercetin, herbacetin, and isobavachalcone as the most promising flavonoids with anti-CoV potential.

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“…Medicinal plants and plant-based natural compounds are the rich source for the development of novel antiviral drugs. Some of the plant"s secondary metabolites have shown potent antiviral activities against different viral strains including coronavirus, herpes simplex, influenza virus, human immunodeficiency virus, SARS and MERS (Xian et al, 2020). Various studies have been running to explore the antiviral mechanism of these natural compounds to inhibit viral entry, replication, assembly, as well as virushost interactions.…”

Section: Introductionmentioning

confidence: 99%

Plant-Derived Secondary Metabolites as Potential Mediators against COVID-19: A Review

et al. 2020

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The current pandemic of COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has envisioned a global health concern. The scientists and physicians around the world have been racing to understand the pathophysiology and possible treatment régimes to discover an effective therapeutic resolution against the disease. Different secondary metabolites from plants exhibit substantial biological assets including antiviral activity. These compounds may be used against the infections of coronavirus. The research papers, reviews, and preprints were searched from the PubMed database using keywords like severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome (MERS), and traditional herbal medicine against COVID-19. The review focuses on those natural products which exhibited optimistic results against SARS-COV and SARS-CoV-2 in virtual as well as physical in vitro and in vivo tests. It summarizes the epidemiological characters, pathogenesis, structure, and targeting strategies of the virus. The compounds like lycorine, psoralidin, quercetin, glycyrrhizin, baicalin, caffeic acid, etc. could be the leads for the drug development against COVID-19.

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Bioactive natural compounds against human coronaviruses: a review and perspective

Cited by 155 publications

References 109 publications

Network machine learning maps phytochemically rich “Hyperfoods” to fight COVID-19

Network machine learning maps phytochemically rich “Hyperfoods” to fight COVID-19

Flavonoids: A complementary approach to conventional therapy of COVID-19?

Plant-Derived Secondary Metabolites as Potential Mediators against COVID-19: A Review

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