Bioactive Natural Compounds from the Plant Endophytic Fungi Pestalotiopsis spp.

Wang, Kuiwu; Lei, Jinxiu; Ji, Wei; Yao, Nan

doi:10.2174/138955712804586710

Cited by 1 publication

(1 citation statement)

References 34 publications

(52 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For example, some endophytic fungi with the ability to produce bioactive compounds of plant origin, such as paclitaxel, onychotoxin, camptothecin, vincristine, chrysin, and diosgenin, are gradually being exploited. [6,7]. Therefore, fully exploiting the utilization of certain endophytic fungi present in medicinal plants has potentially great application value in the production of natural bioactive compounds.…”

Section: Introductionmentioning

confidence: 99%

Genome sequencing analysis of the endophytic fungus Aspergillus tamarii TPD11

Zhang,

Liu,

Zhao

et al. 2023

Preprint

View full text Add to dashboard Cite

Background The excavation and utilization of endophytic fungi from medicinal plants is of great importance for the development of new drugs. The endophytic fungus Aspergillus tamarii TPD11, which was isolated and obtained by the authors in the previous stage, can produce a variety of polyphyllin with important potential applications in hemostasis, inflammation and antitumor, however, the genomic information of TPD11 is still unknown. Results In this study, we sequenced and assembled the whole genome of the endophytic fungus A. tamarii TPD11, resolved the genomes of 24 Aspergillus for relationships, and phylogenetic analysis of the genomes of 16 strains revealed the evolutionary differences between Aspergillus and Penicillium and the mechanisms of genome expansion and contraction. CAZy annotation analysis showed that TPD11 obtains nutrients mainly by ingesting starch from the host plant. TPD11 has a biosynthetic gene cluster for the synthesis of squalestatin S1, and the silencing of this biosynthetic gene cluster might have a positive effect on increasing the content of polyphyllin. Annotation to 11 UDP-glycosyltransferase genes helps to further reveal the biosynthetic pathway of polyphyllin. In addition, secondary metabolism gene clusters and CAZy analysis confirmed the potential pro-biotic, insecticidal and antimicrobial activities of TPD11 on host plants. Conclusions This study reveals the intrinsic mechanism of endophytic fungi to promote the content of polyphyllin in paris, which provides a basis for the synthetic synthesis of the natural product polyphyllin.

show abstract

Section: Introductionmentioning

confidence: 99%