Bioactive Natural Leads Targeting Cancer Cell Metabolism

Dey, Prasanta Kumar; Kundu, Amit; Kar, Babli; Bhakta, Anushree; Vishal, Vineet; Keerthana, S; Kumar, Anoop; Bhakta, Tejendra; Dash, Susmita; Kim, Hyung Sik

doi:10.1007/978-981-15-8127-4_2

Cited by 1 publication

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“…Since primordial times, natural medicinal plants containing different phytochemicals such as alkaloids, glycosides, steroids, flavonoids, tannins, and polysaccharides, which help to cure various diseases, have been used [ 22 , 23 , 24 , 25 , 26 , 27 , 28 ]. Previous studies have shown that the methanol extracts from the leaves of MR contain several compounds including steroids, alkaloids, and flavonoids.…”

Section: Discussionmentioning

confidence: 99%

Molineria recurvata Ameliorates Streptozotocin-Induced Diabetic Nephropathy through Antioxidant and Anti-Inflammatory Pathways

et al. 2022

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Molineria recurvata (MR) has been traditionally used to manage diabetes mellitus in India. However, the molecular mechanism of MR on the diabetic-induced nephropathy has not been clearly investigated. Thus, this study investigates the protective effects of the MR extract on nephropathy in streptozotocin (STZ)-induced diabetic rats. Diabetes was instigated by a single intraperitoneal injection of STZ (45 mg/kg) in male Sprague-Dawley rats. Once the diabetes was successfully induced, the MR extract (200 mg/kg/day) or metformin (200 mg/kg/day) was orally administered for 14 days. Renal function, morphology changes and levels of inflammatory cytokines were measured. Blood glucose concentrations were considerably reduced in STZ-induced diabetic rats following treatment with the MR extract. The administration of the MR extract substantially restored the abnormal quantity of the oxidative DNA damage marker 8-hydroxy-2′-deoxy-guanosine (8-OHdG), malondialdehyde, glutathione, oxidized glutathione, superoxide dismutase, catalase, interleukin (IL)-1β, IL-6, IL-10, and transforming growth factor-β (TGF-β). The urinary excretion of kidney injury molecule-1 (KIM-1), neutrophil gelatinase-associated lipocalin (NGAL), selenium binding protein 1 (SBP1), and pyruvate kinase M2 (PKM2) was significantly reduced in diabetes rats after administration of the MR extracts. In the kidneys of STZ-induced diabetic rats, the MR extracts markedly downregulated the expression of fibronectin, collagen-1, and α-smooth muscle actin (α-SMA). In particular, the MR extracts markedly increased the level of SIRT1 and SIRT3 and reduced claudin-1 in the kidney. These results suggest that the MR extracts exhibits therapeutic activity in contrast to renal injury in STZ-induced diabetic rats through repressing inflammation and oxidative stress.

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