Bioactive PCL microspheres with enhanced biocompatibility and collagen production for functional hyaluronic acid dermal fillers

Abstract

Polymeric microspheres containing magnesium hydroxide (MH) and a bioactive agent (BA), such as apocynin (APO) and astaxanthin (ATX), have been prepared as functional dermal fillers with enhanced physicochemical and biological performance.

Preparation and morphology control of porous microspheres of different crystalline polymers

“…Like PLLA, it is also suitable for subcutaneous implantation in the face to correct long-term facial wrinkles, signs of aging, or any age-related condition of the face and hand rejuvenation. 10 It also has better viscoelasticity than other biodegradable polymers, making it easy to manufacture and operate, and can be made into a variety of structures (microspheres, fibers, micelles, films, nanofibers, foams, etc. ).…”

Multifunctional porous microspheres encapsulating oncolytic bacterial spores and their potential for cancer immunotherapy

“…Microspheres, which have been extensively explored as drug delivery systems, are spherical microparticles in the range of 1–1000 μm and can carry a variety of functions based on the material and structure. 25–31 Since porous microspheres have a low mass density and a wide surface area, due to their linked internal and external pores, they can serve as carriers for biopharmaceuticals, including therapeutic proteins, peptides, and genes. 32–34 Magnetic microspheres can be effectively directed to a diseased region with the aid of an external magnetic field and utilized for image-guided treatment with magnetic resonance (MR) imaging.…”

An Efficient Strategy for Fabricating and Controlling the Morphology of Hollow Poly(p-dioxanone) Microspheres Using an O/W Emulsions Solvent Evaporation Method

“…5 Compared with semicrystalline PCL, the ether bond in PPDO greatly enhances its hydrophilicity, and the complete degradation and absorption cycle of the material is about 6 months, 8,9 which is much faster than that of PCL. 10 PPDO sutures have been widely used to tighten and lift the facial tissue, 11 while similar polyesters, such as PLLA and PCL are used in the form of particles. 10,12 Recently PPDO has shown the features of stimulating collagen regeneration and can be regarded as a potential dermal filler, for which further study is needed.…”

“…PPDO sutures have been widely used to tighten and lift the facial tissue, while similar polyesters, such as PLLA and PCL are used in the form of particles. , Recently PPDO has shown the features of stimulating collagen regeneration and can be regarded as a potential dermal filler, for which further study is needed. , However, PPDO is rarely prepared into regular microspheres, and the morphology of the microspheres is without control. Tae-Rin Kwon et al have begun to analyze PPDO as an injection material to prepare PPDO into irregular particles or powders for filling irregular facial tissue defects.…”