Bioactive peptide functionalized superparamagnetic iron oxide nanoparticles (SPIONs) for targeted imaging with MRI

Sardan, Melis; Eren, E.; Özdemir, Ayşe; Tekinay, Ayşe B.; Güler, Mustafa O.

doi:10.1109/iwmpi.2015.7107067

Cited by 3 publications

(2 citation statements)

References 3 publications

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“…PEG is thought to display good resistance against nonspecific protein adsorption in large part due to its extensive hydrogen bonding with water [20]. SPIONs are often coated with PEG in addition to targeting moieties such as antibodies, peptides, or aptamers, [7], [21] and have been thoroughly reported in the literature for in vivo imaging of early disease markers.…”

Section: Introductionmentioning

confidence: 99%

Assessment of Superparamagnetic Iron Oxide Nanoparticle Poly(Ethylene Glycol) Coatings on Magnetic Resonance Relaxation for Early Disease Detection

Meisel

Bainbridge

Mulkern

et al. 2020

IEEE Open J. Eng. Med. Biol.

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Section: Introductionmentioning

confidence: 99%

Assessment of Superparamagnetic Iron Oxide Nanoparticle Poly(Ethylene Glycol) Coatings on Magnetic Resonance Relaxation for Early Disease Detection

Meisel

Bainbridge

Mulkern

et al. 2020

IEEE Open J. Eng. Med. Biol.

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“…To this end, several methods of chemically functionalizing nanoparticle surfaces, thereby targeting them to specific cells or tissues, have been developed. These methods include attachment of biological or biologically derived molecules to the nanoparticle surface, including antibodies, peptides, and aptamers intended to interact with specific proteins. − For some applications (e.g., cancer treatment) these specific interactions may be intended to cause uptake of drug-carrying nanoparticles into cells via receptor-mediated endocytosis. − For other applications (e.g., disease detection) it is simply necessary for the interaction between the targeting moiety and the target to cause association of the nanoparticle with the disease target. , These targeting methods have shown high rates of success in vitro ; however, they have often failed in vivo. − …”

Section: Introductionmentioning

confidence: 99%

Targeted Nanoparticle Binding to Hydroxyapatite in a High Serum Environment for Early Detection of Heart Disease

Meisel

Bainbridge

Mitsouras

et al. 2018

ACS Appl. Nano Mater.

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The impact of the protein-rich in vivo environment on targeted binding of functionalized nanoparticles has been an active field of research over the past several years. Current research aims at better understanding the nature of the protein corona and how it may be possible for targeted binding to occur even in the presence of serum. Much of the current research focuses on nanoparticles targeted to particular cell receptors or features with the aim of cellular uptake. However, similar research has not been performed on nanoparticles that are targeted to non-protein disease features, such as hydroxyapatite (HA). HA is a crystalline calcium-phosphate mineral that is present in large quantities in bone, and in smaller quantities in diseased cardiovascular tissue in cases of atherosclerosis or various stenoses. Our work aims to gain a better understanding of the behavior of PEGylated, peptide-coated superparamagnetic iron oxide nanoparticles (SPIONs) in a biologically-relevant high-protein environment (50% serum). We first determined that specific binding to HA occurs at significantly higher rates than non-specific binding in the absence of serum protein. We then examined nanoparticle interactions with serum proteins, including determination of the relative quantities of protein in the hard vs. soft protein corona. Finally, we examined specific and non-specific binding of targeted SPIONs in 50% serum, and determined that targeted binding may still occur with significant (p < 0.05) selectivity. We hypothesize that this may be because the nature of the binding interactions between the peptides and the HA are, by definition, less specific than the protein-protein interactions required for nanoparticles to bind to specific cells or cell features. These results suggest that these targeted SPIONs may be further developed for use in early detection of heart diseases such as atherosclerosis and aortic stenosis.

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Surface modification of metal oxide nanoparticles to realize biological applications

Yadav¹,

Bhagat²,

Singh³

2023

Encyclopedia of Nanomaterials

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Bioactive peptide functionalized superparamagnetic iron oxide nanoparticles (SPIONs) for targeted imaging with MRI

Cited by 3 publications

References 3 publications

Assessment of Superparamagnetic Iron Oxide Nanoparticle Poly(Ethylene Glycol) Coatings on Magnetic Resonance Relaxation for Early Disease Detection

Assessment of Superparamagnetic Iron Oxide Nanoparticle Poly(Ethylene Glycol) Coatings on Magnetic Resonance Relaxation for Early Disease Detection

Targeted Nanoparticle Binding to Hydroxyapatite in a High Serum Environment for Early Detection of Heart Disease

Surface modification of metal oxide nanoparticles to realize biological applications

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