Bioactive Peptides and Proteins from Centipede Venoms

Han, Yijing; Kamau, Peter Muiruri; Lai, Ren; Luo, Lei

doi:10.3390/molecules27144423

Cited by 13 publications

(14 citation statements)

References 121 publications

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“…Centipedes belong to the phylum Arthropoda, subphylum Myriapoda, and the Chilopoda class [ 59 ]. There are approximately 3500 species of centipedes divided into five orders: Scutigeromorpha, Lithobiomorpha, Craterostigmomorpha, Geophilomorpha, and Scolopendromorpha [ 55 ].…”

Section: Toxic and Venomous Species Involved In Domestic Animal Poiso...mentioning

confidence: 99%

Zootoxins and Domestic Animals: A European View

Nagy,

Ardelean,

Chapuis

et al. 2024

Toxins

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Zootoxins are produced by venomous and poisonous species and are an important cause of poisoning in companion animals and livestock in Europe. Little information about the incidence of zootoxin poisoning is available in Europe, with only a few case reports and review papers being published. This review presents the most important zootoxins produced by European venomous and poisonous animal species responsible for poisoning episodes in companion animals and livestock. The main zootoxin-producing animal species, components of the toxins/venoms and their clinical effects are presented. The most common zootoxicoses involve terrestrial zootoxins excreted by the common toad, the fire salamander, the pine processionary caterpillar, and vipers. The lack of a centralized reporting/poison control system in Europe makes the evaluation of the epidemiology of zootoxin-induced poisonings extremely difficult. Even if there are many anecdotal reports in the veterinary community about the exposure of domestic animals to terrestrial and marine zootoxins, the number of published papers regarding these toxicoses is low. Climate change and its consequences regarding species distribution and human-mediated transportation are responsible for the emerging nature of some intoxications in which zootoxins are involved. Although new venomous or poisonous animal species have emerged in regions where they were previously unreported, zootoxins produced by native species remain the main concern in Europe. The diversity of poisonous and venomous animal species and the emerging nature of certain poisonings warrant the continuous update to such knowledge by veterinary professionals and animal owners. This review offers an overview about zootoxin-related poisonings in domestic animals in Europe and also provides important information from a health perspective.

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Section: Toxic and Venomous Species Involved In Domestic Animal Poiso...mentioning

confidence: 99%

Zootoxins and Domestic Animals: A European View

Nagy,

Ardelean,

Chapuis

et al. 2024

Toxins

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“…Due to a specific evolutionary process that occurs independently in many animal lineages, the great pharmacological qualities of toxins explain their major impact on the hemostatic, cardiovascular or peripheral nervous systems of prey. Toxins are largely known for their activities in ionic channels and the cardiovascular system, which have been reviewed for conus [ 55 ], snake [ 56 ], scorpion [ 57 ], spider [ 58 ], centipede [ 59 ] and sea anemone [ 60 ]. An increasing number of animal toxins have also been described to be active in GPCRs, with an interesting classification: agonist-mimicking toxins and non-related agonist toxins, as recently reviewed in [ 61 ].…”

Section: Natural Peptide Toxins Targeting V2rmentioning

confidence: 99%

Natural Peptide Toxins as an Option for Renewed Treatment of Type 2 Vasopressin Receptor-Related Diseases

Gilles

2023

Biology

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The type 2 vasopressin receptor (V2R) is expressed in the kidneys, and it is the keystone of water homeostasis. Under the control of the antidiuretic hormone vasopressin, the V2R ensures vital functions, and any disturbance has dramatic consequences. Despite decades of research to develop drugs capable of activating or blocking V2R function to meet real medical needs, only one agonist and one antagonist are virtually used today. These two drugs cover only a small portion of patients’ needs, leaving millions of patients without treatment. Natural peptide toxins known to act selectively and at low doses on their receptor target could offer new therapeutic options.

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“…As a medical invertebrate in China, most studies have focused on the captive breeding of S. mutilans and its medicinal aspects. To the best of our knowledge, there are currently very few explorations of the interactions between S. mutilans and the environment (Han et al, 2022; Tang et al, 2022; Wang et al, 2022). Investigations into the impacts of habitat fragmentation on the genetic diversity and gene flow of S. mutilans in urban ecosystems might contribute to the elucidation of its adaptation to urbanisation and conservation biodiversity.…”

Section: Introductionmentioning

confidence: 99%

Genetic diversity and gene flow of the soil arthropod (Scolopendra mutilans) in urban landscapes: The roles of rivers, mountains and fragmentation

Xu,

Zhou,

et al. 2023

Insect Conserv Diversity

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Soil invertebrates are a major element of soil biodiversity, which play critical roles in soil ecosystems. However, the impacts of urban landscapes on the genetic diversity and gene flows of soil arthropods remain unclear. Here, we studied the genetic diversity and gene flow of Scolopendra mutilans in an urban area using mitochondrial Cytb genes and eight novel microsatellite loci. A total of 22 haplotypes and 24 variation sites were identified based on 556 bp Cytb sequences from 84 individuals of five populations in Nanjing, Jiangsu Province, China. There were 5.63–8.00 alleles in the average of eight microsatellites found in the S. mutilans arthropod populations, which showed high genetic diversity in urban landscapes. There was no correlation between the natural habitat size and genetic diversity of S. mutilans. The global Fst value based on microsatellites was 0.115, which suggested a medium genetic differentiation and population isolation. The genetic structure of S. mutilans might be affected by urbanisation, as urban patches might hinder gene flow between populations. Ecological corridors preserved in cities might serve as pathways for population migration, which increases gene flow. The gene flows of S. mutilans might not be hindered by natural barriers within cities, as there were strong relationships between populations separated by rivers. These results may contribute to the conservation of S. mutilans diversity and elucidate its adaptation to urbanisation.

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Bioactive Peptides and Proteins from Centipede Venoms

Cited by 13 publications

References 121 publications

Zootoxins and Domestic Animals: A European View

Zootoxins and Domestic Animals: A European View

Natural Peptide Toxins as an Option for Renewed Treatment of Type 2 Vasopressin Receptor-Related Diseases

Genetic diversity and gene flow of the soil arthropod (Scolopendra mutilans) in urban landscapes: The roles of rivers, mountains and fragmentation

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