1994
DOI: 10.1016/0196-9781(94)90218-6
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Bioactive peptides in anterior pituitary cells

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Cited by 64 publications
(40 citation statements)
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“…Moreover, the pituitary gland contains several growth factors (17,18), such as insulin-like growth factor (IGF-I/II) (19), epidermal growth factor (20,21), basic ®broblast growth factor (22±24) and transforming growth factor-a/b (18). These growth factors may affect the function and proliferation of pituitary cells through autocrine or paracrine actions in the pituitary (25). We have shown stimulating effects of CRH, AVP, basic ®broblast growth factor, epidermal growth factor and IGF-I on the proliferation of a murine corticotrophic tumour cell line (AtT20) (26).…”
Section: Introductionmentioning
confidence: 95%
“…Moreover, the pituitary gland contains several growth factors (17,18), such as insulin-like growth factor (IGF-I/II) (19), epidermal growth factor (20,21), basic ®broblast growth factor (22±24) and transforming growth factor-a/b (18). These growth factors may affect the function and proliferation of pituitary cells through autocrine or paracrine actions in the pituitary (25). We have shown stimulating effects of CRH, AVP, basic ®broblast growth factor, epidermal growth factor and IGF-I on the proliferation of a murine corticotrophic tumour cell line (AtT20) (26).…”
Section: Introductionmentioning
confidence: 95%
“…Elevated follistatin expression is most likely a result of increased activin levels present in the ActA-only treated group, given that follistatin is an activin antagonist (Shimonaka et al 1991). As activin is known to increase the amount of FSHR available (Findlay 1993, Houben & Denef 1994, Figure 4 Expression of follistatin, activin bA and bB subunits, and FSH receptor in rat ovaries cultured for 10 days. All mRNA was normalized to Gapdh mRNA expression.…”
Section: Controlmentioning
confidence: 99%
“…In addition to control by hypothalamic and systemic factors, secretion of hormones by the anterior pituitary (AP) appears to be influenced by intercellular interactions within the gland itself [for reviews, see 1, 2]. In a growing number of cases, factors, which have a demonstrated effect when added exogenously to AP cells, have been found to be expressed by AP cells.…”
Section: Introductionmentioning
confidence: 99%