Bioactive Phenolic Amides from Celtis africana

Al‐Taweel, Areej Mohammad; Perveen, Shagufta; El-Shafae, Azza M.; Fawzy, Ghada Ahmed; Malik, Abdul; Afza, Nighat; Iqbal, Lubna; Latif, Mehreen

doi:10.3390/molecules17032675

Cited by 62 publications

(52 citation statements)

References 11 publications

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“…The known compounds ( 2 – 7 ) were identified, through comparison of their spectroscopic and physical properties with literature values, as the sesquiterpene (−)-guaiol ( 2 ) [ 18 ], the aporphine alkaloid (+)-isocorydine ( 3 ) [ 19 ], the azafluorenones cyathocaline ( 4 ) [ 20 ], and isoursoline ( 5 ) [ 21 ] and the cinnamoyl tyramides N - trans -coumaroyltyramine ( 6 ) [ 22 ] and N - trans -feruloyltyramine ( 7 ) [ 23 ].…”

Section: Resultsmentioning

confidence: 99%

A New Benzophenone C-Glucoside and Other Constituents of Pseuduvaria fragrans and Their α-Glucosidase Inhibitory Activity

et al. 2018

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Phytochemical investigations of the leaves and stems of Pseuduvaria fragrans led to the isolation of a new benzophenone C-glucoside named pseuduvarioside (1), together with six known compounds including (−)-guaiol (2), (+)-isocorydine (3), cyathocaline (4), isoursoline (5), N-trans-coumaroyltyramine (6), and N-trans-feruloyltyramine (7). Their structures were characterized by NMR spectroscopy and mass spectrometry. All of the isolates were evaluated for inhibitory activity against the enzyme α-glucosidase. N-trans-coumaroyltyramine and N-trans-feruloyltyramine showed higher activity than the drug acarbose. Kinetic studies revealed that both tyramine-derived amides were uncompetitive inhibitors of the enzyme.

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Section: Resultsmentioning

confidence: 99%

A New Benzophenone C-Glucoside and Other Constituents of Pseuduvaria fragrans and Their α-Glucosidase Inhibitory Activity

et al. 2018

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“…30 On the basis of our results and those published in previous reports, phenolic amide derivatives isolated from T. terrestris could be potential candidates for development as an anti-inflammatory agent that exerts its therapeutic effects through inhibition of NO production.…”

Section: -15mentioning

confidence: 51%

Phenolic Amides from the Fruits of Tribulus terrestris and Their Inhibitory Effects on the Production of Nitric Oxide

Hong¹,

Jeong²,

Kwon³

et al. 2013

Bulletin of the Korean Chemical Society

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“…N-trans-ρ-caffeoyl tyramine (CT) is one of the compounds isolated from T. terrestris (7). A previous study reported that CT acts as an antioxidant and moderately inhibits acetylcholinesterase in vitro and in vivo (8). However, the anti-inflammatory effects of CT have not yet been completely elucidated.…”

Section: Introductionmentioning

confidence: 99%

N-trans-ρ-caffeoyl tyramine isolated from Tribulus terrestris exerts anti-inflammatory effects in lipopolysaccharide-stimulated RAW 264.7 cells

Ahn

2015

International Journal of Molecular Medicine

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Inflammation is induced by the expression of cyclooxygenase‑2 (COX‑2), which is an important mediator of chronic inflammatory diseases, such as rheumatoid arthritis, asthma and inflammatory bowel disease. Tribulus terrestris (T. terrestris) is known to have a beneficial effect on inflammatory diseases. In this study, we investigated the effects of N‑trans‑ρ‑caffeoyl tyramine (CT) isolated from T. terrestris on the production of nitric oxide (NO), and the expression of pro‑inflammatory cytokines and COX‑2 in lipopolysaccharide (LPS)‑stimulated RAW 264.7 cells. We also aimed to elucidate the molecular mechanisms involved. We found that the ethanolic extract of T. terrestris (EETT) and CT inhibited the production of NO, tumor necrosis factor‑α (TNF‑α), interleukin (IL)‑6 and IL‑10 in the LPS‑stimulated RAW 264.7 cells in a dose‑dependent manner. They were determined by reverse transcription-polymerase chain reaction (RT-PCR) and enzyme-linked immunosorbent assay (ELISA). In addition, CT markedly suppressed the expression of COX‑2 and the production of prostaglandin E2 (PGE2) in response to LPS stimulation. Furthermore, CT markedly decreased p‑c‑Jun N‑terminal kinase (p‑JNK) protein expression in LPS‑stimulated RAW 264.7 cells. COX-2 and p-JNK were measured by western blot analysis. Taken together, these findings indicate that CT isolated from T. terrestris is a novel and potent modulator of inflammatory responses. Thus, it may prove benefiical to further evaluate CT as a possible treatment for chronic inflammatory diseases.

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Bioactive Phenolic Amides from Celtis africana

Cited by 62 publications

References 11 publications

A New Benzophenone C-Glucoside and Other Constituents of Pseuduvaria fragrans and Their α-Glucosidase Inhibitory Activity

A New Benzophenone C-Glucoside and Other Constituents of Pseuduvaria fragrans and Their α-Glucosidase Inhibitory Activity

Phenolic Amides from the Fruits of Tribulus terrestris and Their Inhibitory Effects on the Production of Nitric Oxide

N-trans-ρ-caffeoyl tyramine isolated from Tribulus terrestris exerts anti-inflammatory effects in lipopolysaccharide-stimulated RAW 264.7 cells

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