2023
DOI: 10.1002/mabi.202300153
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Bioactive Phenylboronic Acid‐Functionalized Hyaluronic Acid Hydrogels Induce Chondro‐Aggregates and Promote Chondrocyte Phenotype

Abstract: Hydrogels are extensively investigated as biomimetic extracellular matrix (ECM) scaffolds in tissue engineering. The physiological properties of ECM affect cellular behaviors, which is an inspiration for cell‐based therapies. Photocurable hyaluronic acid (HA) hydrogel (AHAMA‐PBA) modified with 3‐aminophenylboronic acid, sodium periodate, and methacrylic anhydride simultaneously is constructed in this study. Chondrocytes are then cultured on the surface of the hydrogels to evaluate the effect of the physicochem… Show more

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Cited by 5 publications
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“…This library, specifically created for soft hydrogels (E = 10-50 kPa), can be employed to encapsulate various cells, such as human chondrocytes. [56] Low-stiffness hyaluronic acid hydrogels modified with phenylboronic acid (E < 5 kPa) promote a transparent phenotype in chondrocytes, [57] while a stiffer matrix (E > 20 kPa) may be more suitable for the deposition of cartilaginous matrix based on chondrocytes. [58,59] Polyethylene glycol hydrogels, simulating a gradient stiffness characteristic of cartilage (2-60 kPa), can induce specific responses in chondrocytes, promoting ECM deposition in simulated cartilage-like tissue.…”
Section: Discussionmentioning
confidence: 99%
“…This library, specifically created for soft hydrogels (E = 10-50 kPa), can be employed to encapsulate various cells, such as human chondrocytes. [56] Low-stiffness hyaluronic acid hydrogels modified with phenylboronic acid (E < 5 kPa) promote a transparent phenotype in chondrocytes, [57] while a stiffer matrix (E > 20 kPa) may be more suitable for the deposition of cartilaginous matrix based on chondrocytes. [58,59] Polyethylene glycol hydrogels, simulating a gradient stiffness characteristic of cartilage (2-60 kPa), can induce specific responses in chondrocytes, promoting ECM deposition in simulated cartilage-like tissue.…”
Section: Discussionmentioning
confidence: 99%