Bioactive Phytochemicals from Nigella sativa Oil Processing By-Products

Ustun-Argon, Zeliha; Gümüş, Zinar Pınar; Çelenk, Veysel Umut; Ramadan, Mohamed Fawzy

doi:10.1007/978-3-030-63961-7_29-1

Cited by 2 publications

(3 citation statements)

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“…sativa is widely known and used in the Arab world, where it is called kalonji and Habbatul Barakah, meaning "seed of blessing" in Arabic. The seeds are often used as an ingredient in bread and pastries, and a dessert made from it is prepared by mixing it with flour and roasting it in the oven (Figure 3) [13,57]. Historical records from various scientific and religious texts have documented the curative properties of N. sativa.…”

Section: Medicinal Plants Used In the Treatment Of Skin Diseasesmentioning

confidence: 99%

“…sativa and thymoquinone have been shown to have a wide range of therapeutic benefits (Figure 4). These characteristics, which include anti-inflammatory, anti-allergic, antioxidant, anticancer, and antibacterial properties among others, have been proven through a variety of in vitro and animal studies [8,57,72]. The positive effects of thymoquinone on skin wound healing are primarily due to the induction of angiogenesis, anti-inflammatory, antioxidant, and antibacterial effects, as well as an increase in fibroblast proliferation and collagen synthesis.…”

Section: The Beneficial Wound-healing Effects Of Thymoquinonementioning

confidence: 99%

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How Thymoquinone from Nigella sativa Accelerates Wound Healing through Multiple Mechanisms and Targets

Kmail,

Said,

Saad

2023

CIMB

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Wound healing is a multifaceted process necessitating the collaboration of numerous elements to mend damaged tissue. Plant and animal-derived natural compounds have been utilized for wound treatment over the centuries, with many scientific investigations examining these compounds. Those with antioxidant, anti-inflammatory, and antibacterial properties are particularly noteworthy, as they target various wound-healing stages to expedite recovery. Thymoquinone, derived from Nigella sativa (N. sativa)—a medicinal herb with a long history of use in traditional medicine systems such as Unani, Ayurveda, Chinese, and Greco-Arabic and Islamic medicine—has demonstrated a range of therapeutic properties. Thymoquinone exhibits antimicrobial, anti-inflammatory, and antineoplastic activities, positioning it as a potential remedy for skin pathologies. This review examines recent research on how thymoquinone accelerates wound healing and the mechanisms behind its effectiveness. We carried out a comprehensive review of literature and electronic databases, including Google Scholar, PubMed, Science Direct, and MedlinePlus. Our aim was to gather relevant papers published between 2015 and August 2023. The main criteria for inclusion were that the articles had to be peer reviewed, original, written in English, and discuss the wound-healing parameters of thymoquinone in wound repair. Our review focused on the effects of thymoquinone on the cellular and molecular mechanisms involved in wound healing. We also examined the role of cytokines, signal transduction cascades, and clinical trials. We found sufficient evidence to support the effectiveness of thymoquinone in promoting wound healing. However, there is no consensus on the most effective concentrations of these substances. It is therefore essential to determine the optimal treatment doses and the best route of administration. Further research is also needed to investigate potential side effects and the performance of thymoquinone in clinical trials.

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Section: Medicinal Plants Used In the Treatment Of Skin Diseasesmentioning

confidence: 99%

Section: The Beneficial Wound-healing Effects Of Thymoquinonementioning

confidence: 99%

How Thymoquinone from Nigella sativa Accelerates Wound Healing through Multiple Mechanisms and Targets

Kmail,

Said,

Saad

2023

CIMB

View full text Add to dashboard Cite

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“…The evidenced therapeutic properties reflect its valuable constituents [ 19 ]. Nigella sativa contains various nutrients, such as protein, carbohydrate, fats and fibers, in addition to different amino acids, and minerals, including calcium, copper, iron, zinc and folic acid [ 20 ]. Moreover, NS contains up to 34% fixed oils and 2.5% essential oils.…”

Section: Introductionmentioning

confidence: 99%

Development and Optimization of Nigella sativa Nanoemulsion Loaded with Pioglitazone for Hypoglycemic Effect

2022

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Diabetes mellitus (DM) is a metabolic disorder associated with an increased blood glucose level. The world health burden of DM has increased as a result of numerous causes that necessitates suitable treatment. Pioglitazone (PGZ) is a generally prescribed medication for managing type II diabetes. However, its low solubility creates complications for its formulation. Therefore, the aim of the current study was to incorporate PGZ into a nanoemulsion (NE) formulation prepared with Nigella sativa oil (NSO) to boost the action of PGZ. To our knowledge, no previous study has addressed the combination and synergistic effect of PGZ and NSO as a hypoglycemic NE formulation intended for oral administration. An experiment was designed to test several PGZ-loaded NE formulations, varying factors such as NSO, surfactant and co-surfactant concentrations. These factors were investigated for their influence on responses including particle size and in vitro release. An optimized PGZ-loaded NE was selected and examined for its morphology, kinetic activity and stability. Further, the anti-diabetic effect of the optimized formulation was evaluated using diabetically induced rats. The optimized formula exhibited a good particle size of 167.1 nm and in vitro release of 89.5%. A kinetic study revealed that the drug release followed the Korsmeyer–Peppas mechanism. Additionally, the PGZ-loaded NE formulation was found to be stable, showing non-significant variation in the evaluated parameters when stored at 4 and 25 °C for a period of 3 months. In vivo investigation of the PGZ-loaded NE formulation showed a significant reduction in blood glucose level, which appeared to be enhanced by the presence of NSO. In conclusion, NS-NE could be a promising nanocarrier for enhancing the hypoglycemic effect of PGZ.

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Bioactive Phytochemicals from Nigella sativa Oil Processing By-Products

Cited by 2 publications

References 93 publications

How Thymoquinone from Nigella sativa Accelerates Wound Healing through Multiple Mechanisms and Targets

How Thymoquinone from Nigella sativa Accelerates Wound Healing through Multiple Mechanisms and Targets

Development and Optimization of Nigella sativa Nanoemulsion Loaded with Pioglitazone for Hypoglycemic Effect

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