Bioactive Phytochemicals of Leaf Essential Oils of Cinnamomum osmophloeum Prevent Lipopolysaccharide/<scp>d</scp>-Galactosamine (LPS/<scp>d</scp>-GalN)-Induced Acute Hepatitis in Mice

Tung, Yu Tang; Huang, Chi‐Chang; Ho, Shang Tse; Kuo, Yueh Hsiung; Lin, Chi Chen; Lin, Chien Tsong; Wu, June H.

doi:10.1021/jf2018935

Cited by 48 publications

(29 citation statements)

References 23 publications

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“…Humulene has been reported to produce anti-inflammatory effect and also has inhibitory effect on tumor necrosis factor- α -/(TNF- α ) and interleukin-1 β (IL1B) [ 30 ]. α -Cadinol is an antifungal [ 31 ] and hepatoprotective [ 32 ]. C 14 H 14 O is arachidic acid, a saturated fatty acid [ 33 ], C 20 H 40 O 2 is phytanic acid, a branched fatty acid, and its metabolites have been reported to bind or activate transcription factors [ 34 ].…”

Section: Discussionmentioning

confidence: 99%

Effect ofCentella asiaticaLeaf Extract on the Dietary Supplementation in TransgenicDrosophilaModel of Parkinson’s Disease

Siddique

Naz

Jyoti

et al. 2014

Parkinson's Disease

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The role of Centella asiatica L. leaf extract was studied on the transgenic Drosophila model flies expressing normal human alpha synuclein (h-αS) in the neurons. The leaf extract was prepared in acetone and was subjected to GC-MS analysis. C. asiatica extract at final concentration of 0.25, 0.50, and 1.0 μL/mL was mixed with the diet and the flies were allowed feeding on it for 24 days. The effect of extract was studied on the climbing ability, activity pattern, lipid peroxidation, protein carbonyl content, glutathione content, and glutathione-S-transferase activity in the brains of transgenic Drosophila. The exposure of extract to PD model flies results in a significant delay in the loss of climbing ability and activity pattern and reduced the oxidative stress (P < 0.05) in the brains of PD flies as compared to untreated PD flies. The results suggest that C. asiatica leaf extract is potent in reducing the PD symptoms in transgenic Drosophila model of Parkinson's disease.

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Section: Discussionmentioning

confidence: 99%

Effect ofCentella asiaticaLeaf Extract on the Dietary Supplementation in TransgenicDrosophilaModel of Parkinson’s Disease

Siddique

Naz

Jyoti

et al. 2014

Parkinson's Disease

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“…Terpinenes: Borneol; camphene; camphor; limonene; linalool; myrcene; p-cymene; spathulenol; viridiflorol; b-caryophyllene; b-pinene; d-cadinene; ⍺-cadinol; ⍺pinene; ⍺-terpineol [176] [209] Kaempferol glycosides: [210] Anticancer, [130,211] antidiabetic, [212,213] antidyslipidaemic, [214] antiinflammatory, [209,215] antimicrobial [216,217] , antioxidant, [213,218] cardioprotective, [219] cytotoxicity, [220] hair growth, [221] hepatoprotective, [222] hypolipidaemic effect, [223] hypouricaemic effects, [224] immunomodulatory, [225] larvicidal, [29] pancreas-protective effect, [226] tyrosinase, [220,227] wound healing, [227] xanthine oxidase inhibitory [224] Arthritis, [228] cough and cold, [228] diabetes, [228] infection, [222] inflammation, [228] nerve pains, [228] pyrexia [228] Bark Flavonoids: (E)-Cinnamaldehyde; (Z)cinnamaldehyde. [229] Hydrocarbon: Phenol; c-muurolene [229] Flavonoids: cis-Cinnamaldehyde; transcinnamaldehyde [5,230,231] ; cinnamaldehyde.…”

Section: Leavesmentioning

confidence: 99%

Pharmacological properties and their medicinal uses of Cinnamomum: a review

Kumar

Kumari

Mishra

2019

Journal of Pharmacy and Pharmacology

110

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Objectives Cinnamomum (Family Lauraceae) is traditionally used for flavouring food and in pharmaceutical preparations against various ailments. Detailed literature on the ethnobotanical and pharmacological properties of Cinnamomum is segregated and not present in well-documented form. In the present review, we have been trying to gather its detailed medicinal as well as pharmacological properties. The ethnobotanical and pharmacological properties of Cinnamomum were collected by searching several scientific databases, that is PubMed, Elsevier, Google Scholar, Science Direct and Scopus. Key findings The plant extracts have been reported to possess astringent, warming stimulant, carminative, blood purifier, digestive, antiseptic, antifungal, antiviral, antibacterial, antioxidant, anti-inflammatory and immunomodulatory properties and also help to reduce cholesterol and blood sugar levels. A wide range of phytochemical compounds including aldehydes,

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“…Among them include 9, 12-Octadecadienoic acid (Z, Z)-, methyl ester, a fatty acid methyl ester detected in M. capensis methanol extract has been showed to exhibit antibacterial activity [13]. α-cadinol a sesquiterpene found in the extract of the understudy plant reported to possess antifungal and as hepatoprotective agents [14,15].…”

Section: Resultsmentioning

confidence: 99%

Chemical Constituents, Antioxidative, Cytotoxic, and Genotoxic Effects of Miscanthus Capensis Roots Extract

Sagbo

Otang-Mbeng

2019

Asian J Pharm Clin Res

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Objective: Miscanthus capensis (Nees) Andersson (Poaceae family) is used in traditional medicine to treat pimples, wounds, eczema, acne, and other ailments. The present study investigates the possible chemical constituents, antioxidant, cytotoxic, and genotoxic effects of the methanol extract of the M. capensis roots. Methods: Gas chromatography-mass spectrometry (GC-MS) analysis was carried out to identify the chemical constituents of the plant extract. Cytotoxicity and mode of cell death toward human dermal fibroblasts (MRHF) cells were assessed using the ImageXpress® Micro XLS analysis system. Genotoxic effect toward Vero cells was also investigated using micronucleus assay. Furthermore, ferric reducing power (Ferric reducing antioxidant potential [FRAP]) and reactive oxygen species (ROS) levels in MRHF cells were used to estimate the antioxidant activity of the plant extract. Results: The GC-MS results showed a maximum amount of bioactive components (77 compounds) with rosifoliol (33.66%) being the major component detected. However, the extract was not toxic to MRHF cells but demonstrated anti-proliferation rather than cell death at the tested concentrations (25, 50, and 100 μg/ml). In addition, the plant extract also displayed non-genotoxic toward Vero cells with no significant increase in micronucleus formation at the tested concentration while a concentration dependence response in FRAP values and ROS levels in MRHF cells lines were observed indicating better antioxidant activities of the plant extract. Conclusion: The results suggest that M. capensis could be a promising candidate for preventing or eradicating skin and oxidative-stress related diseases.

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Bioactive Phytochemicals of Leaf Essential Oils of Cinnamomum osmophloeum Prevent Lipopolysaccharide/d-Galactosamine (LPS/d-GalN)-Induced Acute Hepatitis in Mice

Cited by 48 publications

References 23 publications

Effect ofCentella asiaticaLeaf Extract on the Dietary Supplementation in TransgenicDrosophilaModel of Parkinson’s Disease

Effect ofCentella asiaticaLeaf Extract on the Dietary Supplementation in TransgenicDrosophilaModel of Parkinson’s Disease

Pharmacological properties and their medicinal uses of Cinnamomum: a review

Chemical Constituents, Antioxidative, Cytotoxic, and Genotoxic Effects of Miscanthus Capensis Roots Extract

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