Bioactive polymer coatings to improve bone repair

Hélary, G.; Migonney, Véronique

doi:10.1533/9781845696610.2.309

Cited by 4 publications

(2 citation statements)

References 37 publications

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“…A promising alternative method involves grafting, where covalent immobilization of compound takes place to create a resilient film on the material surface. Currently, two main grafting methods are employed: "grafting to" and "grafting from" [126].…”

Section: Polymer Coatingsmentioning

confidence: 99%

Strategies to Enhance Biomedical Device Performance and Safety: A Comprehensive Review

Sánchez-Bodón,

Diaz-Galbarriatu,

Pérez-Álvarez

et al. 2023

Coatings

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This paper reviews different approaches to obtain biomaterials with tailored functionalities and explains their significant characteristics that influence their bioactivity. The main goal of this discussion underscores the significance of surface properties in materials, with a particular emphasis on their role in facilitating cell adhesion in order to obtain good biocompatibility and biointegration, while preventing adverse effects, such as bacterial contamination and inflammation processes. Consequently, it is essential to design strategies and interventions that avoid bacterial infections, reducing inflammation and enhancing compatibility systems. Within this review, we elucidate the most prevalent techniques employed for surface modification, notably emphasizing surface chemical composition and coatings. In the case of surface chemical composition, we delve into four commonly applied approaches: hydrolysis, aminolysis, oxidation, and plasma treatment. On the other hand, coatings can be categorized based on their material composition, encompassing ceramic-based and polymer-based coatings. Both types of coatings have demonstrated efficacy in preventing bacterial contamination, promoting cell adhesion and improving biological properties of the surface. Furthermore, the addition of biological agents such as drugs, proteins, peptides, metallic ions plays a pivotal role in manifesting the prevention of bacterial infection, inflammatory responses, and coagulation mechanism.

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Section: Polymer Coatingsmentioning

confidence: 99%

Strategies to Enhance Biomedical Device Performance and Safety: A Comprehensive Review

Sánchez-Bodón,

Diaz-Galbarriatu,

Pérez-Álvarez

et al. 2023

Coatings

View full text Add to dashboard Cite

show abstract

“…Specifically, the incorporation of nanoscale topographical features aims to interact with specific celltransmembrane receptors (i.e integrins) in attempt to modulate cell adhesion and cytoskeletal tension. These are considered processes that are of vital importance in osteogenesis and osteoconduction However, encapsulation of metallic implants by fibrous tissue, a physiological process that protects the body from foreign bodies, frequently results in arrested bone repair and subsequent implant failure [4][5][6] . To address this challenge, bioactive surfaces have been explored, functional approaches that rely on the formation of a chemically stable bond between the biomaterial surface and the surrounding bone extra cellular matrix without triggering a fibrotic response.…”

Section: Introductionmentioning

confidence: 99%

Enhanced osteoconductivity on electrically charged titanium implants treated by physicochemical surface modifications methods

Fernández‐Yagüe

Antoñanzas

Roa

et al. 2019

Nanomedicine: Nanotechnology, Biology and Medicine

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Following implantation, dental implant stability can become compromised due to poor bone tissue integration and reactive foreign-body encapsulation. A key tenet of bone tissue engineering is biomimetic design, and in particular, the development of responsive surfaces that promote ion exchange with interfacing tissues, facilitating the ionic events that occur naturally during bone repair, hold promise as orthopedic fixation strategies. Herein, simple thermochemical and oxygen plasma processes are described and assessed in vivo as functional approaches for the development of dental implants with enhanced integration potential. Non-bioactive titanium dental implants treated by shot-blasting and acid-etching (AE) (to produce micro to nanoscale hierarchical topographic structure) induced higher bone implant contact (BIC=53% and 68%) compared to shot-blasted treated (SB) implants (BIC=47% and 49%) at weeks 4 and 8, respectively. Plasma (PL) or thermochemical (BIO) processes were subsequently used to produce a bioactive charged surface by selective ion adsorption as indicated by surface zeta potential changes from-34 mV (SB) to-20mV (PL) or-10 mV (BIO). In addition, an increase on the polar component of surface energy was obtained due to higher number of surface hydroxyl groups as indicated by X-ray photoelectron spectroscopy (XPS) and energy-dispersive X-ray spectroscopy analyses (EDX). In vivo results showed that charged implants exhibited enhanced osteoconductivity through ionic surface-tissue exchange (PL, BIC= 69% and 73% and BIO, BIC= 83% and 86 % at weeks 4 and 8 respectively). Furthermore, charged bioactive surfaces (PL and BIO) obtained functional mechanical stability as early as 4 weeks post implantation via increased total bone area (BAT=56% and 59%) ingrowth compared to SB (BAT=35%) and AE (BAT=35%) surfaces. This results correlated positively with clinical evaluation of osseointegration using resonance frequency analysis (RFA). This study describes the development and application of surface functionalization methods to selectively modulate surface charges and enhance implant-bone tissue integration.

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Bioactive Polymers and Surfaces: A Solution for Implant Devices

Migonney¹

2014

Biomaterials

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Bioactive polymer coatings to improve bone repair

Cited by 4 publications

References 37 publications

Strategies to Enhance Biomedical Device Performance and Safety: A Comprehensive Review

Strategies to Enhance Biomedical Device Performance and Safety: A Comprehensive Review

Enhanced osteoconductivity on electrically charged titanium implants treated by physicochemical surface modifications methods

Bioactive Polymers and Surfaces: A Solution for Implant Devices

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