Bioactive polysaccharides promote gut immunity <i>via</i> different ways

Wu, Xincheng; Huang, Xiao‐Jun; Ma, Wanning; Li, Mingzhi; Wen, Jinkun; Chen, Chunhua; Liu, Liandi; Nie, Shaoping

doi:10.1039/d2fo03181g

Cited by 24 publications

(9 citation statements)

References 45 publications

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“…Increasing evidence has demonstrated that Christensenellaceae_R-7_group and norank_f__Muribaculaceae positively regulate nutrient metabolism, whereas Gastranaerophilales and Clostridia_UCG-014 are related to metabolic diseases. 21 In the current study, association analysis revealed that Bacteroidota and Prevotellaceae_NK3B31_group had positive relationships with beta-D-glucosamine, 1-butylamine, leucine, and glutamic acid in plasma. According to these results, FeSuc supplementation may affect critical metabolites such as beta-D-glucosamine, 1-butylamine, leucine, and glutamic acid via modulating the structure of the microbial composition in sows.…”

Section: Papersupporting

confidence: 48%

Ferrous–sucrose complex supplementation regulates maternal plasma metabolism and the fecal microbiota composition and improves neonatal immunity and placental glucose transportation by activating the EGF/PI3K/AKT signaling pathways in sows

Dong,

Liu,

Wan

et al. 2024

Food Funct.

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Section: Papersupporting

confidence: 48%

Ferrous–sucrose complex supplementation regulates maternal plasma metabolism and the fecal microbiota composition and improves neonatal immunity and placental glucose transportation by activating the EGF/PI3K/AKT signaling pathways in sows

Dong,

Liu,

Wan

et al. 2024

Food Funct.

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“…57 Monoglobus also promotes the production of SCFAs. 58 Compared to the normal group, Lachnospiraceae_UCG-006, Turicibacter, and Bifidobacterium were more abundant in the Zein-TSP treatment group (Fig. 6(C)).…”

Section: Species Difference Analysismentioning

confidence: 87%

Fabrication of zein–tamarind seed polysaccharide–curcumin nanocomplexes: their characterization and impact on alleviating colitis and gut microbiota dysbiosis in mice

Xie,

Zhu,

Zeng

et al. 2024

Food Funct.

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“…Monoglobus is a specialized bacterium that breaks down pectin, the main non-cellulosic component of plant cell wall polysaccharides (47,48). Monoglobus promotes the production of short-chain fatty acids and improves the intestinal microenvironment (49). Gut microbes and their metabolites are hubs connecting the liver-brain-reproductive signaling axis to nutritional strategies that regulate laying hen performance, health, and welfare.…”

Section: Discussionmentioning

confidence: 99%

Effects of herbal dregs supplementation of Salvia miltiorrhiza and Isatidis Radix residues improved production performance and gut microbiota abundance in late-phase laying hens

Li,

Ma,

Gong

et al. 2024

Front. Vet. Sci.

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The present study was designed to evaluate the effect of a mixture of Chinese medicinal residues (CMRs) consisting of Salvia miltiorrhiza residues (SMR) and Isatidis Radix residues (IRR) on productive performance, egg quality, serum lipid and hormone levels, liver and blood antioxidant capacity, oviduct inflammation levels, and gut microbiota in the late-laying stage. A total of 288 fifty-four-week-old BaShang long-tailed hens were divided into four groups. The feed trial period was 8 weeks. The control group was fed the basic diet as a CCMR group, supplemented with 3, 4, and 6% for the experimental groups LCMR, MCMR, and HCMR. The egg production rate of the MCMR group was 8.1% higher than that of the CCMR group (p < 0.05). Serum triglyceride (TG) levels of hens of the CMR-supplemented group were significantly decreased than those of the CCMR group (p < 0.05). The group supplemented with different levels of CMR had significantly higher serum HDL-C levels compared with the control group (p < 0.05). Follicle-stimulating hormone (FSH) and luteinizing hormone (LH) levels were remarkably increased for the LCMR and MCMR groups and significantly decreased for the HCMR group compared to CCMR (p < 0.05). Serum and liver glutathione peroxidase (GSH-PX) activities were significantly increased, and malondialdehyde (MDA) levels were significantly decreased in the MCMR group compared to the CCMR group (p < 0.05). The expression levels of tubal inflammatory factor markers (IL-4, IL-1β, TNF-α) in the MCMR and HCMR groups were consistent with the pathological findings of the sections. As for cecal microbiota, supplementation with CMR affected the alpha diversity of the cecum microbiome at the genus level. The Shannon index was significantly higher in the MCMR group than in the CCMR and HCMR groups (p < 0.05). Supplementation with different levels of CMR mainly regulated the ratio of intestinal Firmicutes to Bacteroidetes and the abundance of phyla such as Proteobacteria. In addition, CMR supplementation at different levels in the diet enriched lipid-metabolizing bacteria, such as Bacteroides and Ruminococcus_gnavus_group. Furthermore, according to linear discriminant analysis (LDA) effect size (LEfSe) analysis, the MCMR group showed an increase in the number of short-chain fatty acid-producing bacteria Romboutsia and fiber-degrading specialized bacteria Monoglobus. Therefore, supplementation of appropriate amounts of CMR to the diet of laying hens enhanced reproductive hormone levels, hepatic antioxidant capacity, and lipid metabolism, alleviated the levels of oviductal inflammatory factors, and modulated the abundance structure of bacterial flora to improve the late-laying performance and egg quality. The results of the current study showed that CMR is a beneficial feed supplement for chickens when added in moderation.

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Bioactive polysaccharides promote gut immunity via different ways

Abstract: Our study revealed that different polysaccharides promote gut immunity in different ways and provided a guideline for the development of superior intestinal immunomodulatory polysaccharides.

Cited by 24 publications

References 45 publications

Ferrous–sucrose complex supplementation regulates maternal plasma metabolism and the fecal microbiota composition and improves neonatal immunity and placental glucose transportation by activating the EGF/PI3K/AKT signaling pathways in sows

Ferrous–sucrose complex supplementation regulates maternal plasma metabolism and the fecal microbiota composition and improves neonatal immunity and placental glucose transportation by activating the EGF/PI3K/AKT signaling pathways in sows

Fabrication of zein–tamarind seed polysaccharide–curcumin nanocomplexes: their characterization and impact on alleviating colitis and gut microbiota dysbiosis in mice

Effects of herbal dregs supplementation of Salvia miltiorrhiza and Isatidis Radix residues improved production performance and gut microbiota abundance in late-phase laying hens

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