Bioactive Prenylated Xanthones from the Young Fruits and Flowers of <i>Garcinia cowa</i>

Sriyatep, Teerayut; Siridechakorn, Ittipon; Maneerat, Wisanu; Pansanit, Acharavadee; Ritthiwigrom, Thunwadee; Andersen, Raymond J.; Laphookhieo, Surat

doi:10.1021/np5008476

Cited by 50 publications

(41 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The other tested compounds were less effective, with IC 50 values ranging from 11.7 ± 0.1 to 55.3 ± 0.2 mM[55]. The 12 xanthones 81 and 102e112 isolated from the bark of G. xanthochymus exhibited a strong activity in the inhibition of a-glucosidase, except for compounds 81 and 104 which were inactive in this assay.…”

mentioning

confidence: 88%

“…Plants of the Garcinia species (Clusiaceae family) are known to possess oxygenated and prenylated xanthones. The structures isolated from different parts of eight species (G. mangostana [44], G. nobilis [54], G. cowa [55], G. xanthochymus [62], G. oblongifolia [63], G. fusca [42], G. paucinervis [45] and G. hanburyi [49]) and their inhibitory activity against a-glucosidase are presented in Table 4.…”

Section: Xanthone Derivatives As A-glucosidase Inhibitorsmentioning

confidence: 99%

“…Inhibitory effect of isolated xanthones 65e145 from the fruit case Garcinia mangostana [44], stem bark of Garcinia nobilis [54], young fruits and flowers of Garcinia cowa [55], bark of Garcinia xanthochymus [62], twigs of Garcinia oblongifolia [63], roots of G. fusca [42], leaves of G. paucinervis [45] and from the resin of Garcinia hanburyi [49] on…”

Section: Tablementioning

confidence: 99%

See 2 more Smart Citations

A comprehensive review on xanthone derivatives as α-glucosidase inhibitors

Santos

Freitas

Fernandes

2018

European Journal of Medicinal Chemistry

165

View full text Add to dashboard Cite

a-Glucosidase plays an important role in carbohydrate metabolism and is therefore an attractive therapeutic target for the treatment of diabetes, obesity and other related complications. In the last two decades, considerable interest has been given to natural and synthetic xanthone derivatives in this field of research. Herein, a comprehensive review of the literature on xanthones as inhibitors of a-glucosidase activity, their mechanism of action, experimental procedures and structure-activity relationships have been reviewed for more than 280 analogs. With this overview we intend to motivate and challenge researchers (e.g. chemistry, biology, pharmaceutical and medicinal areas) for the design of novel xanthones as multipotent drugs and exploit the properties of this class of compounds in the management of diabetic complications.

show abstract

mentioning

confidence: 88%

Section: Xanthone Derivatives As A-glucosidase Inhibitorsmentioning

confidence: 99%

Section: Tablementioning

confidence: 99%

See 1 more Smart Citation

A comprehensive review on xanthone derivatives as α-glucosidase inhibitors

Santos

Freitas

Fernandes

2018

European Journal of Medicinal Chemistry

165

View full text Add to dashboard Cite

show abstract

“…The reaction was incubated at 37°C for 20 min and stopped by the addition of 1 mL 1 M of Na 2 CO 3 solution. The α-glucosidase activity was determined by measuring the amount of p-nitrophenol released from p-NPG at 405 nm using a microplate reader (SPECTROstar Nano) [16]. Blanks were prepared by adding solvent instead of samples.…”

Section: Dpph Radical Scavenging Assaymentioning

confidence: 99%

“…The latter compounds were founds as major phytochemicals in this genus and many of these compounds had broad spectrum biological activities such as anti-inflammatory [4] and anti-HIV activities [7], cholinesterase [5] and PDE5 inhibitory activities [8], and their antimicrobial [9], cytotoxic [10], and antioxidant [2] activities. In the course of our ongoing search for bioactive compounds from natural resources from the northern part of Thailand [12][13][14][15][16], we report here the first phytochemical investigation of the twig extracts of M. fruticosa (Roxb.) Corner (Figure 1) collected from Doi Tung, Chiang Rai Province, Thailand resulting in the isolation and identification of a new xanthone (1) together with 14 known compounds (2-15) ( Figure 2).…”

mentioning

confidence: 99%

Antioxidant, Cytotoxic and α-Glucosidase Inhibitory Activities of Compounds isolated from the Twig Extracts of Maclura fruticosa

Polbuppha

Maneerat

Sripisut

et al. 2017

Natural Product Communications

Self Cite

View full text Add to dashboard Cite

The first phytochemical investigation of the twig extracts of Maclura fruticosa led to the isolation and identification of a new xanthone, maclurafruticosone (1), together with 14 known compounds (2-15). All compounds were elucidated using spectroscopic methods as well as through comparisons made with data reported in the literature. Some isolated compounds were evaluated for their antioxidant, α-glucosidase inhibitory and cytotoxic activities. Compound 4, 6 and 7 showed significant antioxidant activity against DPPH radicals with IC 50 values ranging from 7.45-16.12 µM. Compound 4 also exhibited potent activity against ABTS + scavenging activity with an IC 50 value of 0.55 ± 0.01 µM which was better than positive control (ascorbic acid, IC 50 2.35 ± 0.17 µM). Compound 12 showed significant α-glucosidase inhibitory activity with an IC 50 value of 0.02 ± 0.37 mM. Compounds 5, 6 and 12 showed weak cytotoxic activities against a colon cancer cell line with IC 50 values ranging from 22.35-47.62 µM.

show abstract

Garcinia gummi‐gutta: Phytochemicals and pharmacological applications

et al. 2023

View full text Add to dashboard Cite

Garcinia gummi-gutta, also known as Garcinia cambogia, is a member of the Guttiferae family. Garcinia is a polygamous genus consisting 200 species of trees and shrubs. It is found in different zones of the planet including Asia's tropical regions. In India alone, around 30 species have been discovered. They are widely used as a flavoring agent to garnish fish curry in southern India, particularly in Kerala and Karnataka. The fruit rind of G. gummi-gutta has traditionally been used to treat gastrointestinal problems, diarrhea, and ulcers. South Indian people have been utilizing it traditionally as evidenced by its ethnobotanical properties. In vivo and in vitro effects of the crude fruit extract showed anti-inflammatory, anti-cancer, anthelmintic, anti-microbial, and antioxidant activities. G. gummi-gutta fruit rind is medicinally significant and is frequently used in ayurvedic and traditional medicine for many diseases. Various secondary metabolites such as organic acids-hydroxycitric acid (HCA), flavonoids, terpenes, polysaccharides and polyisoprenylated benzophenonesgarcinol, xanthochymol, guttiferone, benzophenone, xanthone, biflavonoids, alkaloids, tannins, phenols, and saponins isolated from the G. gummi-gutta have diverse pharmacological activities. This review provides a summary of G. gummi-gutta, including its biological activities, phytochemistry, and ethnobotanical applications.

show abstract

Bioactive Prenylated Xanthones from the Young Fruits and Flowers of Garcinia cowa

Cited by 50 publications

References 23 publications

A comprehensive review on xanthone derivatives as α-glucosidase inhibitors

A comprehensive review on xanthone derivatives as α-glucosidase inhibitors

Antioxidant, Cytotoxic and α-Glucosidase Inhibitory Activities of Compounds isolated from the Twig Extracts of Maclura fruticosa

Garcinia gummi‐gutta: Phytochemicals and pharmacological applications

Contact Info

Product

Resources

About