Bioactive profile, health benefits and safety evaluation of sea buckthorn (Hippophae rhamnoides L.): A review

Wani, Touseef Ahmed; Wani, Shoib Mohmad; Ahmad, Mukhtar; Ahmad, Mudasir; Gani, Adil; Masoodi, F.A.

doi:10.1080/23311932.2015.1128519

Cited by 49 publications

(42 citation statements)

References 42 publications

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“…The search for agents that turn off the production of virulent factors or diminish their expression can bring about a new generation of species-specific antivirulent drugs. In the case of SBT products, they have applications in the supportive therapy of local skin lesions, mucosal infections, and associated inflammatory symptoms in wound healing and other conditions [ 8 , 9 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 ], directions that are in part reflected in the topics of ongoing clinical trials [ 10 ]. However, the sites of possible action of SBT-derived compounds in human body are the niches richly inhabited by many microorganisms constituting natural microbiota, which play a significant role in the host immune system [ 19 , 20 ].…”

Section: Resultsmentioning

confidence: 99%

Phenolic and Nonpolar Fractions of Elaeagnus rhamnoides (L.) A. Nelson Extracts as Virulence Modulators—In Vitro Study on Bacteria, Fungi, and Epithelial Cells

et al. 2018

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Butanol extracts from leaves, twigs, and fruits of Elaeagnus rhamnoides (L.) A. Nelson (sea buckthorn, SBT) were fractionated into phenolic and nonpolar lipid components, the chemical composition of which was analyzed. Assuming that an effect on natural microbiota and host epithelial cells needs to be assessed, regardless of the purpose of using SBT formulations in vivo, the minimal inhibitory/biocidal/fungicidal concentrations (MICs/MBCs/MFCs) of the fractions and reference phytocompounds were screened, involving 17 species of Gram-positive and Gram-negative bacteria and Candida species. The MICs of SBT extracts were in the range of 0.25–2.0 mg∙mL−1. Since direct antimicrobial activity of the extracts was quite low and variable, the impact of subMIC on the important in vivo persistence properties of model microorganisms S. aureus and C. albicans was evaluated. Tests for adhesion and biofilm formation on an abiotic surface and on surfaces conditioned with fibrinogen, collagen, plasma, or artificial saliva showed the inhibitory activity of the fractions. The effects on fluorescein isothiocyanate (FITC)-labeled staphylococci adhesion to fibroblasts (HFF-1) and epithelial cells (Caco-2), and on fungal morphogenesis, indicated that SBT extracts have high antivirulence potential. Cytotoxicity tests (MTT reduction) on the standard fibroblast cell line showed variable biological safety of the fractions depending on their composition and concentration. The new information afforded by this study, additional to that already known, is of potential practical value in the application of SBT-derived preparations as antivirulence agents.

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Section: Resultsmentioning

confidence: 99%

Phenolic and Nonpolar Fractions of Elaeagnus rhamnoides (L.) A. Nelson Extracts as Virulence Modulators—In Vitro Study on Bacteria, Fungi, and Epithelial Cells

et al. 2018

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“…The antioxidant activity of sea buckthorn (H. rhamnoides L.) is mainly due to the redox characteristics of polyphenolic compounds, which mainly contain flavonoids, phenolic acids and tannins. In particular, kaempferol, quercetin, isorhamnetin, catechin, procyanidins and gallic acid are commonly present as bioactive compounds [11]. H. rhamnoides L. is a good source of active phenols for human consumption, and it plays an important role in many physiological and metabolic processes.…”

Section: Introductionmentioning

confidence: 99%

Advanced Research on the Antioxidant Activity and Mechanism of Polyphenols from Hippophae Species—A Review

Gong

et al. 2020

Molecules

108

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Oxidation is a normal consequence of metabolism in biological organisms. The result is the formation of detrimental reactive oxygen species (ROS) and reactive nitrogen species (RNS). A large number of studies have shown that polyphenolic compounds have good antioxidant properties. Hippophae species plants have high polyphenolic content and are widely used in food, medicinal, or the cosmetic field. The main polyphenols in Hippophae species are flavonoids, phenolic acids and tannins, which have multiple effects. However, there is a limited number of studies on polyphenols in Hippophae species plants. This review systematically summarizes the polyphenols compounds and antioxidant activity of Hippophae species plants, and it is noteworthy that the main mechanisms of the polyphenols of Hippophae with antioxidant activity have been summarized as follows: regulating enzyme activity, affect the antioxidant reaction of cells, and others. This review provides useful information for the further study and application of Hippophae species polyphenols and their antioxidant activity.

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“…The broad spectrum of activity of FAs makes them attractive antibacterial and antioxidant agents for various applications in medicine, agriculture and food preservation, especially when the use of conventional antibiotics and antioxidants is undesirable or prohibited. Due to its richness in bioactive compounds like FAs, the sea buckthorn was used traditionally against various diseases Stobdan et al 2013;Wani et al 2016).…”

Section: Introductionmentioning

confidence: 99%

Benefits of sea buckthorn (Hippophae rhamnoides) pulp oil‐based mouthwash on oral health

Smida

Pentelescu

et al. 2019

J Appl Microbiol

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Aim The purpose of this study was to conduct phytochemical analysis of sea buckthorn pulp oil and to evaluate the antimicrobial, anti‐biofilm and antioxidant activities of its mouthwash form. Methods and Results Fatty acid composition of the sea buckthorn pulp oil was determined by GC‐MS analysis, which revealed that, mono‐unsaturated fatty acid, palmitoleic acid and saturated fatty acid, palmitic acid, were the major constituents. The antimicrobial and the anti‐biofilm capacities of sea buckthorn pulp oil mouthwash form were evaluated against Streptococcus gordonii, Porphyromonas gingivalis, Actinomyces viscosus and Candida albicans, according to the European Norms, and the Biofilm Ring Test®, respectively. These activities were then compared with those of chlorhexidine and herbal mouthwashes. The sea buckthorn‐based mouthwash was bactericidal against S. gordonii and P. gingivalis, bacteriostatic against A. viscosus and showed no antifungal effect. Regardless of the strains used, complete inhibition of biofilm formation was achieved. The antioxidant activity of this experimental mouthwash was also assessed by DPPH and NBT assays. Conclusion Sea buckthorn mouthwash showed anti‐biofilm activities against select single and multiple oral bacterial species. Significance and Impact of the Study In this study, a mouthwash derived from sea buckthorn (Hippophae rhamnoides) pulp oil has been experimented, for the first time, in order to overcome the problem of a large number of available synthetic mouthwashes which have side effects on teeth, gums and mucous membranes. This mouthwash seemed to be a suitable alternative for a preventive agent for periodontal inflammation.

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Bioactive profile, health benefits and safety evaluation of sea buckthorn (Hippophae rhamnoides L.): A review

Cited by 49 publications

References 42 publications

Phenolic and Nonpolar Fractions of Elaeagnus rhamnoides (L.) A. Nelson Extracts as Virulence Modulators—In Vitro Study on Bacteria, Fungi, and Epithelial Cells

Phenolic and Nonpolar Fractions of Elaeagnus rhamnoides (L.) A. Nelson Extracts as Virulence Modulators—In Vitro Study on Bacteria, Fungi, and Epithelial Cells

Advanced Research on the Antioxidant Activity and Mechanism of Polyphenols from Hippophae Species—A Review

Benefits of sea buckthorn (Hippophae rhamnoides) pulp oil‐based mouthwash on oral health

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