Bioactive Secondary Metabolites from a Thai Collection of Soil and Marine-Derived Fungi of the Genera Neosartorya and Aspergillus

Zin, War War May; Prompanya, Chadaporn; Buttachon, Suradet; Kijjoa, Anake

doi:10.2174/1567201813666160303104641

Cited by 16 publications

(5 citation statements)

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“…Noteworthy, these derivatives showed higher potency than the natural product neoscalin A (2), (tested by the same group with the same conditions). 32,47,48 None of the pure enantiomers was active against the fungi tested.…”

Section: Microbiologymentioning

confidence: 99%

New marine-derived indolymethyl pyrazinoquinazoline alkaloids with promising antimicrobial profiles

et al. 2020

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Section: Microbiologymentioning

confidence: 99%

New marine-derived indolymethyl pyrazinoquinazoline alkaloids with promising antimicrobial profiles

et al. 2020

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“…In our research program with an objective to search for new bioactive compounds from marine-derived fungi, we investigated several members of the genus Neosartorya (Trichocomaceae) isolated from different marine organisms such as sponges, coral, and algae. Many different chemical classes of secondary metabolites, such as polyketides, isocoumarins, ergosterol derivatives, meroditerpenes, pyripyropenes, benzoic acid derivatives, prenylated indole derivatives, tryptoquivalines, fiscalins, phenylalanine-derived alkaloids, and cyclopeptides, have been isolated and investigated for their anticancer and antibacterial activities [ 5 , 6 , 7 ]. Therefore, in our ongoing search for new natural antibiotics from marine-derived fungi, we investigated secondary metabolites from the culture of N. spinosa KUFA 1047, isolated from a marine sponge Mycale sp., which was collected from the Samae San Island in the Gulf of Thailand.…”

Section: Introductionmentioning

confidence: 99%

Anthraquinones, Diphenyl Ethers, and Their Derivatives from the Culture of the Marine Sponge-Associated Fungus Neosartorya spinosa KUFA 1047

et al. 2021

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Previously unreported anthraquinone, acetylpenipurdin A (4), biphenyl ether, neospinosic acid (6), dibenzodioxepinone, and spinolactone (7) were isolated, together with (R)-6-hydroxymellein (1), penipurdin A (2), acetylquestinol (3), tenellic acid C (5), and vermixocin A (8) from the culture of a marine sponge-associated fungus Neosartorya spinosa KUFA1047. The structures of the previously unreported compounds were established based on an extensive analysis of 1D and 2D NMR spectra as well as HRMS data. The absolute configurations of the stereogenic centers of 5 and 7 were established unambiguously by comparing their calculated and experimental electronic circular dichroism (ECD) spectra. Compounds 2 and 5–8 were tested for their in vitro acetylcholinesterase and tyrosinase inhibitory activities as well as their antibacterial activity against Gram-positive and Gram-negative reference, and multidrug-resistant strains isolated from the environment. The tested compounds were also evaluated for their capacity to inhibit biofilm formation in the reference strains.

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“…Recent research shows that marine fungi contain a high diversity of putatively novel taxa (Comeau et al, 2016; Ishino et al, 2016; Picard, 2017), some of which may have medical applications (Hasan et al, 2015; Zin et al, 2016). Perhaps the best-described communities of reef-associated fungi are those growing on or in corals.…”

Section: Introductionmentioning

confidence: 99%

Fungi associated with mesophotic macroalgae from the ‘Au‘au Channel, west Maui are differentiated by host and overlap terrestrial communities

Wainwright

Zahn

Spalding

et al. 2017

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Mesophotic coral ecosystems are an almost entirely unexplored and undocumented environment that likely contains vast reservoirs of undescribed biodiversity. Twenty-four macroalgae samples, representing four genera, were collected from a Hawaiian mesophotic reef at water depths between 65 and 86 m in the ‘Au‘au Channel, Maui, Hawai‘i. Algal tissues were surveyed for the presence and diversity of fungi by sequencing the ITS1 gene using Illumina technology. Fungi from these algae were then compared to previous fungal surveys conducted in Hawaiian terrestrial ecosystems. Twenty-seven percent of the OTUs present on the mesophotic coral ecosystem samples were shared between the marine and terrestrial environment. Subsequent analyses indicated that host species of algae significantly differentiate fungal community composition. This work demonstrates yet another understudied habitat with a moderate diversity of fungi that should be considered when estimating global fungal diversity.

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Bioactive Secondary Metabolites from a Thai Collection of Soil and Marine-Derived Fungi of the Genera Neosartorya and Aspergillus

Cited by 16 publications

References 0 publications

New marine-derived indolymethyl pyrazinoquinazoline alkaloids with promising antimicrobial profiles

New marine-derived indolymethyl pyrazinoquinazoline alkaloids with promising antimicrobial profiles

Anthraquinones, Diphenyl Ethers, and Their Derivatives from the Culture of the Marine Sponge-Associated Fungus Neosartorya spinosa KUFA 1047

Fungi associated with mesophotic macroalgae from the ‘Au‘au Channel, west Maui are differentiated by host and overlap terrestrial communities

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