Bioactive Terpenes from Marine-Derived Fungi

Abstract

Marine-derived fungi continue to be a prolific source of secondary metabolites showing diverse bioactivities. Terpenoids from marine-derived fungi exhibit wide structural diversity including numerous compounds with pronounced biological activities. In this review, we survey the last five years’ reports on terpenoidal metabolites from marine-derived fungi with particular attention on those showing marked biological activities.

Selected Fungal Natural Products with Antimicrobial Properties

“…The broad-spectrum activity of these two compounds was linked with their action as inhibitors of glucan biosynthesis [110]. The majority of bioactive fungal terpenes and terpenoids discovered in the past decade were isolated from marine fungi and fungi associated with algae [111]. For instance, peribysins 50-56 ( Figure 5) are sesquiterpenes which were isolated from the dothideomycete Periconia byssoides, and are able to inhibit the development of leukemia cancer cells even at low concentrations, making compounds in this family potential anti-cancer drugs [112].…”

Marine Pharmacology in 2014–2015: Marine Compounds with Antibacterial, Antidiabetic, Antifungal, Anti-Inflammatory, Antiprotozoal, Antituberculosis, Antiviral, and Anthelmintic Activities; Affecting the Immune and Nervous Systems, and Other Miscellaneous Mechanisms of Action

“…In 2014-2015, several reviews covered general and/or specific areas of marine preclinical pharmacology: (a) Marine pharmacology and marine pharmaceuticals: new marine natural products and relevant biological activities published in 2014 and 2015 [311,312]; marine peptides, bioactivities and applications [313]; bioactive terpenes from marine-derived fungi [314]; bioactive marine natural products from actinobacteria with unique chemical structures [315]; Baltic cyanobacteria as a source of biologically active compounds [316]; biological targets of marine cyanobacteria natural products [317]; marine mussels as a source for bioactive compounds for human health [318]; pharmacological potential of cephalopod ink in drug discovery [319]; pharmacologically active Brazilian octocorals [320]; bioactive natural products isolated from marine microorganisms from Brazil [321]; statistical analysis of marine natural product bioactivity from 1985-2012 [322]; metagenomics and marine natural products drug discovery [323]; new horizons for selected marine natural products as drug leads [324]; marine-sourced agents in clinical and late preclinical development [325]; the global marine pharmaceutical pipeline in 2019: approved compounds and those in Phase I, II, and III of clinical development https://www.midwestern.edu/departments/marinepharmacology.xml. (b) Antimicrobial marine pharmacology: biophysical properties of anti-lipopolysaccharide antimicrobial peptides isolated from marine fish [326]; marine peptides and their anti-microbial activities [327]; marine membrane-active peptides as antimicrobials [328]; marine fungi antibacterial compounds [329].…”

Antartin, a Cytotoxic Zizaane-Type Sesquiterpenoid from a Streptomyces sp. Isolated from an Antarctic Marine Sediment

“…Sesquiterpenes comprise an important class of natural products with diverse bioactivities including antibacterial, antifungal, antiviral, antitumor, cytotoxic, and immunosuppressive activities [ 1 , 2 , 3 , 4 , 5 , 6 ]. As secondary metabolites, sesquiterpenes are commonly produced from terrestrial organisms.…”