Bioactivities of isolated and synthetic riparins of Aniba riparia (NEES) MEZ (LAURACEAE): A brief review

Barbosa, Cristina Rodrigues dos Santos; Bezerra, Antônio Henrique; Bezerra, Suieny Rodrigues; Macêdo, Nair Silva; Oliveira-Tintino, Cícera Datiane de Morais; Costa, José Galberto Martins da; Coutinho, Henrique Douglas Melo; Santos, Hélcio Silva dos; Cunha, Francisco Assis Bezerra da

doi:10.1016/j.phytol.2022.10.009

Cited by 5 publications

(2 citation statements)

References 57 publications

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“…Riparins are found in several plant species with economic and ethnopharmacological values, especially those from the Aniba gender (Rang et al, 2012). Indeed, riparins I, II, and III have been isolated from Aniba riparia (Nees) Mez (Barbosa et al, 2022). Riparins I and III present antidepressant and anxiolytic properties, while riparin II presents only the anxiolytic effect (de Sousa et al 2005;2007;Vasconcelos et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

New insights about the antidepressant-like effects of riparin A in a chronic murine model of depression

Prinholato da Silva,

Oliveira,

Benincasa

et al. 2024

Behavioural Pharmacology

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Riparin A is a synthetic form of natural riparins. Acute scale studies that take into consideration the structure–activity relationship have shown preliminary evidence of antidepressant and anxiolytic effects of riparin A, similar to that already known for other riparins. However, for better pharmacological characterization of this new compound, further studies are required. The aim of this work was to evaluate the effect of chronic treatment with riparin A (10 mg/kg; intraperitoneally) on depressive-like behavior in the forced swimming test and tail suspension test, as well as the reduction of anhedonia in the sucrose preference test, and on anxiety-like behavior in the open field and elevated plus maze apparatus, triggered in rats previously subjected to unpredictable chronic mild stress by 4 weeks. In addition, a pentobarbital-induced sleep time test was also used. Riparin A reduced the duration of immobility in both the forced swimming test and tail suspension test, as well as attenuated the anhedonia in the sucrose preference test. Furthermore, riparin A appears to produce anxiolytic effects in rats exposed to an open field and elevated plus maze, while increasing the alertness/vigilance in rats submitted to pentobarbital-induced sleep time test, without altering their locomotor integrity. Our results suggest that chronic riparin A appears to be a potential pharmacological target for new studies on the control of depression- and anxiety-like behaviors in stressed rats.

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Section: Introductionmentioning

confidence: 99%

New insights about the antidepressant-like effects of riparin A in a chronic murine model of depression

Prinholato da Silva,

Oliveira,

Benincasa

et al. 2024

Behavioural Pharmacology

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“…Among these are the synthetic prototypes isolated from the green fruit of Aniba riparia (Nees) Mez, Lauraceae, a typical plant from the Amazon region, where it is popularly known as “louro” [ 2 , 3 ]. A. riparia is of great interest as a medicinal plant due to its chemical composition of alkaloids of the alkamide type known as riparins, which have an amide function formed from the condensation of a saturated fatty acid and an amine group, with few representatives in nature [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Improving Riparin-A Dissolution through a Laponite Based Nanohybrid

et al. 2023

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(1) Background: Riparin-A presents several pharmacological activities already elucidated, such as antimicrobial modulator, antileishmania, anxiolytic, anti-inflammatory, antinociceptive, and antioxidant. Even with important bioactive effects, the applicability of Riparin-A is limited due to its low solubility in water, impairing its dissolution in biological fluids. Thus, the objective of this study was to develop a nanohybrid based on Riparin-A and Laponite to obtain a better dissolution profile and evaluate its cytotoxic potential. (2) Methods: The formation of a hybrid system was highlighted by X-ray powder diffraction, infrared spectroscopy, and thermal analysis. Solubility, dissolution, and cytotoxicity studies were performed; (3) Results: An increase in the solubility and aqueous dissolution rate of Riparin-A was observed in the presence of clay. Diffractometric analysis of the hybrid system suggests the amorphization of Riparin-A, and thermal analyses indicated attenuation of decomposition and melting of the Riparin-A after interaction with clay. Furthermore, the nanosystem did not exhibit cytotoxic activity on normal and tumorigenic lines. (4) Conclusions: These results are promising for the development of the Riparin-A/Laponite nanosystem for therapeutic purposes, suggesting an increase in the range of possible routes of administration and bioavailability of this bioactive compound.

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Alkaloids from Houttuynia cordata Thunb. and their chemotaxonomic significance

Pham

Cao

et al. 2023

Biochemical Systematics and Ecology

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Bioactivities of isolated and synthetic riparins of Aniba riparia (NEES) MEZ (LAURACEAE): A brief review

Cited by 5 publications

References 57 publications

New insights about the antidepressant-like effects of riparin A in a chronic murine model of depression

New insights about the antidepressant-like effects of riparin A in a chronic murine model of depression

Improving Riparin-A Dissolution through a Laponite Based Nanohybrid

Alkaloids from Houttuynia cordata Thunb. and their chemotaxonomic significance

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