Bioactivities of serotonin transporter mediate antidepressant effects of Acorus tatarinowii Schott

Zhang, Fenghong; Wang, Zhimei; Liu, Yanting; Liang, Shuang; Wu, Hong‐Hua; Xu, Yan‐Tong

doi:10.1016/j.jep.2019.111967

Cited by 29 publications

(10 citation statements)

References 16 publications

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“…The chemical constituents of the EOs of ATR mainly contain lignans, phenylpropanoids, and terpenoids. , Among them, asarone-based phenylpropanoids (α-asarone and β-asarone) are the characteristic constituents. As a type of solvent extraction device, a Soxhlet extractor (Figure S1) has its own advantages in EO extraction .…”

Section: Resultsmentioning

confidence: 99%

GC–MS Analysis of Essential Oil Extracted from Acori tatarinowii Rhizoma: An Experiment in Natural Product Analysis

Zhang

Wang

et al. 2021

J. Chem. Educ.

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A comprehensive undergraduate experiment about extraction, separation, and identification of essential oils (EOs) from a natural plant is described. Acori tatarinowii Rhizoma (ATR) was used as the raw plant material. Two devices (Soxhlet and Clevenger) with different extraction principles were employed for EO extraction from ATR, separately. The chemical compounds of the extracted EOs were separated and identified by gas chromatography−mass spectrometry (GC−MS). The differences in the chemical components obtained by the two extraction devices were compared. The experiment can give students a deep insight into the difference between the extraction methods. Additionally, the experiment can enable students to learn how to use GC−MS to identify the chemical structures of the extracted complex samples. The grouped students who performed this experiment gained a deep understanding of extraction and detection techniques, as well as the benefits of teamwork.

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Section: Resultsmentioning

confidence: 99%

GC–MS Analysis of Essential Oil Extracted from Acori tatarinowii Rhizoma: An Experiment in Natural Product Analysis

Zhang

Wang

et al. 2021

J. Chem. Educ.

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“…In addition, in the tail suspension test that evaluates the antidepressant property of KG-HE extract, KG-treated rats showed a significantly reduced immobility time compared to untreated controls. An increase in immobility time is usually referred to as behavioral despair in animals and is claimed to represent human depression [36][37][38], suggesting that the KG-treated rats were prevented from depressive-like behaviors. Previous studies by Gardier and colleague [39] showed that a decrease in immobility was linked to antidepressant activity [40][41][42].…”

Section: Discussionmentioning

confidence: 99%

<i>Khaya grandifololia</i> Improves Cognition and Prevents Scopolamine-Induced Impairment of Brain Functions by Activating the Cholinergic and Antioxidant Systems in Rats

Ella¹,

Fewou²,

Koloko³

et al. 2022

AJBLS

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Alzheimer's disease (AD) is a multifactorial, progressive neurodegenerative disorder with dementia and persistent impairment of cognitive functions as the main clinical characteristics. Although signs of progress are being made in developing AD therapy, there is no effective drug capable of stopping and/or slowing down the progression of the disease. We have previously indicated in an in vitro setting of AD that Khaya grandifololia (KG) crude extract possesses antioxidant, antiinflammatory, and neuroprotective activities. In the current work, we have evaluated the activity of KG hydroethanolic (KG-HE) extract in preventing cognitive impairment and promoting memory improvement in vivo. Results from behavioral tests indicated a significant improvement in memory performance and a delay in depression-like behavior upon treatment of rats with KG-HE extract (5, 25, and 50 mg/kg) or donepezil (1 mg/kg) as standard. Because scopolamine (1 mg/kg) impaired cognitive performance in the tail suspension test, Morris Water Maze test, and Novelty Suppressed Feeding Test, KG-HE extract (5, 25, and 50 mg/kg) or donepezil (1 mg/kg) treatment prevented scopolamine-induced performance impairment. Moreover, both KG-HE extract (5, 25, and 50 mg/kg) and donepezil (1 mg/kg) prevented the scopolamine-induced cognitive impairment by inhibiting the acetylcholinesterase activity. In addition, the brain parameters of stress oxidation (SOD, CAT, and GSH) reduced by scopolamine treatment were regulated by the administration of KG-HE extract or the standard drug donepezil. An increase in the MDA level and the phosphatase activity both in the serum and brain due to scopolamine treatment was restored by the administration of KG-HE extract or donepezil. Taken together, these results suggest that KG-HE extract improves cognition and relieves the scopolamine-induced cognitive impairment via activation of the cholinergic and anti-oxidation systems in rats.

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“…angustatus shows antidepressant-like effects in the FST and TST, but not in the OFT [35][36][37]. Using these same tests, Han et al [35] demonstrated that the essential oil from the rhizomes of the plant, along with its major compounds, principally β-asarone (47, Fig. 6S, Supplementary Information), exert antidepressantlike effects.…”

Section: Experimental Studies In Animals or Cellsmentioning

confidence: 94%

“…Both the essential oil and the water extract of Acorus calamus var. angustatus shows antidepressant-like effects in the FST and TST, but not in the OFT [35][36][37]. Using these same tests, Han et al [35] demonstrated that the essential oil from the rhizomes of the plant, along with its major compounds, principally β-asarone (47, Fig.…”

Section: Experimental Studies In Animals or Cellsmentioning

confidence: 97%

Untitled

2021

Planta Med

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Depression is a syndrome characterized by profound sadness and a global inhibition of psychic functions. It is also the most common mental alteration among the general population, affecting about 322 million people worldwide [1]. It is estimated that the number of people living with depression increased by roughly 18 % between 2005 and 2015, making it one of the great epidemics of the 21st century [2]. Depression manifests itself as sadness, hopelessness, apathy, and anhedonia, with feelings of worthless-

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Bioactivities of serotonin transporter mediate antidepressant effects of Acorus tatarinowii Schott

Cited by 29 publications

References 16 publications

GC–MS Analysis of Essential Oil Extracted from Acori tatarinowii Rhizoma: An Experiment in Natural Product Analysis

GC–MS Analysis of Essential Oil Extracted from Acori tatarinowii Rhizoma: An Experiment in Natural Product Analysis

<i>Khaya grandifololia</i> Improves Cognition and Prevents Scopolamine-Induced Impairment of Brain Functions by Activating the Cholinergic and Antioxidant Systems in Rats

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Bioactivities of serotonin transporter mediate antidepressant effects of Acorus tatarinowii Schott

Cited by 29 publications

References 16 publications

GC–MS Analysis of Essential Oil Extracted from Acori tatarinowii Rhizoma: An Experiment in Natural Product Analysis

GC–MS Analysis of Essential Oil Extracted from Acori tatarinowii Rhizoma: An Experiment in Natural Product Analysis

&lt;i&gt;Khaya grandifololia&lt;/i&gt; Improves Cognition and Prevents Scopolamine-Induced Impairment of Brain Functions by Activating the Cholinergic and Antioxidant Systems in Rats

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<i>Khaya grandifololia</i> Improves Cognition and Prevents Scopolamine-Induced Impairment of Brain Functions by Activating the Cholinergic and Antioxidant Systems in Rats