Bioactivity and antidiabetic properties of Malva parviflora L. leaves extract and its nano-formulation in streptozotocin-induced diabetic rats

Mohammed, Dina Mostafa; Elsayed, Nesren; Baker, Doha H. Abou; Ahmed, Kawkab A.; Sabry, Bassem A.

doi:10.1016/j.heliyon.2022.e12027

Cited by 12 publications

(8 citation statements)

References 58 publications

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“…A diet high in vegetables and, eventually, antioxidant components was widely established to lessen the incidence of numerous illnesses such as cancer and coronary artery disease. Identification of the substances that promote a healthy diet was thus crucial [ 49 ].…”

Section: Resultsmentioning

confidence: 99%

The protective effects of some herbs on mitigating HFD-induced obesity via enhancing biochemical indicators and fertility in female rats

Abdoon,

Hegazy,

Abdel-Azeem

et al. 2024

Heliyon

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Section: Resultsmentioning

confidence: 99%

The protective effects of some herbs on mitigating HFD-induced obesity via enhancing biochemical indicators and fertility in female rats

Abdoon,

Hegazy,

Abdel-Azeem

et al. 2024

Heliyon

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“…The peel extracts were transformed into a nanoemulsion using a modified version of the method described in a previous study [ 23 ]. To create the emulsion, 3% (w/v) carboxy-methylcellulose (CMC-food grade) was dissolved in double-distilled water and mechanically stirred for 4 h at 40 °C.…”

Section: Methodsmentioning

confidence: 99%

Validating the protective role of orange and tangerine peel extracts foramending food safety against microorganisms’ contamination using molecular docking

Sabry,

Badr,

Mohammed

et al. 2024

Heliyon

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“…The samples were investigated using a transmission electron microscope (TEM) (JEM − 1234) with a 120 KV operating voltage, a magnification power of 600,000 x, a resolving power of 0.3 nm, a CCD camera, and a programmed heating/cooling facility ranging from − 190 0 C to 1000 0 C. On a copper grid with a carbon coating, samples were kept [ 45 , 46 ].…”

Section: Methodsmentioning

confidence: 99%

Mitigation of intrahepatic cholestasis induced by 17α-ethinylestradiol via nanoformulation of Silybum marianum L.

Salem,

Mohammed,

Hammam

et al. 2024

BMC Complement Med Ther

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Background Cholestasis is an important predisposing factor for hepatocyte damage, liver fibrosis, primary biliary cirrhosis, and even liver failure. Silybum marianum L. (SM) plant is used in teas or eaten in some countries due to its antioxidant and hepatoprotective properties. Because of its low and poor oral bioavailability, so we improve the therapeutic activity of Silybum marianum L. extract (SM) by studying the potential effects of nanoformulation of Silybum marianium L. extract (nano-SM) on 17α-ethinylestradiol (EE)-induced intrahepatic cholestasis. Methods Thirty female Sprague-Dawley rats were divided into 5 groups (6 rats/group). Group I: Rats were received the treatment vehicle and served as normal group. Group II:Rats were injected daily with EE (10 mg/kg) for five successive days. Group III-V: Rats were injected daily with EE (10 mg/kg) and treated with either Ursodeoxycholic acid (UDCA) (40 mg/kg), SM (100 mg/kg) and nano-SM (100 mg/kg) orally once/day throughout the trialfor five successive days, respectively. Results Nano-SM greatly dampened the increase in serum levels of total and direct bilirubin, alanine aminotransaminase, aspartate aminotransaminase, and alkaline phosphatase caused by EE. Furthermore, nano-SM increased the hepatic contents of reduced glutathione (GSH) and catalase (CAT) and also upregulated the relative hepatic gene expressions of Rho-kinase (ROCK-1), myosin light chain kinase (MLCK), and myosin phosphatase target subunit (MYPT1) compared to the EE-induced group. Administration of nano-SM reduced hepatic lipid peroxidation and downregulated the relative hepatic expressions of the nuclear factor-kappa B (NF-ҡB) and interleukin-1β (IL-1β). In addition, nano-SM improved the histopathological changes induced by EE. Conclusion Nano-SM possessed a superior effect over SM, which can be considered an effective protective modality against EE-induced cholestatic liver injury through its antioxidant, anti-inflammatory activities, and enhancing bile acid (BA) efflux.

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Bioactivity and antidiabetic properties of Malva parviflora L. leaves extract and its nano-formulation in streptozotocin-induced diabetic rats

Cited by 12 publications

References 58 publications

The protective effects of some herbs on mitigating HFD-induced obesity via enhancing biochemical indicators and fertility in female rats

The protective effects of some herbs on mitigating HFD-induced obesity via enhancing biochemical indicators and fertility in female rats

Validating the protective role of orange and tangerine peel extracts foramending food safety against microorganisms’ contamination using molecular docking

Mitigation of intrahepatic cholestasis induced by 17α-ethinylestradiol via nanoformulation of Silybum marianum L.

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