Bioactivity and cytocompatibility of zirconia (ZrO2) films fabricated by cathodic arc deposition

Liu, Xuanyong; Huang, Anping; Ding, Chuanxian; Chu, Paul K.

doi:10.1016/j.biomaterials.2006.03.007

Cited by 107 publications

(62 citation statements)

References 33 publications

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“…The surface charge of the ZrO 2 is generally regarded to be negative [22,45]. Filtered cathodic arc deposition is a very efficient method for producing nanostructured films and the AFM result indicated that the TiO 2 and ZrO 2 films deposited by filtered cathodic arc deposition have a nanostructured surface.…”

Section: Discussionmentioning

confidence: 99%

“…The as-deposited films were fabricated in the laboratory of Shanghai Institute of Ceramics using a filtered cathodic arc system [22]. The samples were processed with deposition using filtered Ti cathodic arc plasma sources for TiO 2 films and Zr cathodic arc plasma sources for ZrO 2 films in oxygen atmosphere.…”

Section: Materials Preparationmentioning

confidence: 99%

“…ZrO 2 thin films deposited on Si wafers using plasmaassisted cathodic arc deposition has also been proved to be bioactive and cytocompatible [22]. But ZrO 2 films deposited by cathodic arc deposition for surface modification of Ti substrates are rarely reported.…”

Section: Introductionmentioning

confidence: 99%

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Biological Behavior of Osteoblast-like Cells on Titania and Zirconia Films Deposited by Cathodic Arc Deposition

Zhang

Sun

et al. 2012

Biointerphases

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Cathodic arc deposition technique was used to deposit zirconia (ZrO2) films and titania (TiO2) films on titanium (Ti) disks respectively. The surface topography was characterized by scanning electron microscopy and atomic force microscopy. The element composition of the films was detected by X-ray photoelectron spectroscopy. The phase of films was identified by thin film X-ray diffraction. The biological behavior of osteoblast-like MG63 cells cultured on Ti, TiO2 and ZrO2 was investigated and the possible signaling molecules involved was studied by the gene expressions of integrin β1, extracellular related kinase 1/2 (ERK1/2), and c-fos. The results indicated that both the TiO2 and ZrO2 films were amorphous. Scanning electron microscopy study showed that the adhesion of MG63 cells on TiO2 and ZrO2 films was significantly enhanced compared to Ti. The CCK8 assay indicated that the TiO2 and ZrO2 films promoted the proliferation of MG-63 cells. The alkaline phosphatase (ALP) activity test and the production of type collagen I (COLI) by immunofluorescence showed that both the TiO2 and ZrO2 films can enhance ALP activity and COLI expression of MG-63 cells. In addition, the ALP activity on ZrO2 films was higher than on TiO2 films at day 4, which indicate ZrO2 films may lead to promotion of a more osteoblastic phenotype of MG-63 cells than TiO2 films. Real-time polymerase chain reaction analysis demonstrated that The gene expression of integrin β1, ERK1/2, and c-fos was higher on TiO2 and ZrO2 films than on Ti. The present work suggests that the amorphous ZrO2 films produced by cathodic arc deposition may be favorable for orthopedic implant applications and worth further study.

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Section: Discussionmentioning

confidence: 99%

Section: Materials Preparationmentioning

confidence: 99%

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Biological Behavior of Osteoblast-like Cells on Titania and Zirconia Films Deposited by Cathodic Arc Deposition

Zhang

Sun

et al. 2012

Biointerphases

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“…Spośród wszystkich porcelan tlenek cyrkonu cechuje się najwyższą wytrzymałością mechaniczną, a odporność na złamania osiąga wartość do 2000N [5]. Prócz tego jest ogniotrwały (temperatura topnienia 2850°C), moduł Younga podobny do stopów stali nierdzewnej, odporny na korozję w kwaśnym środowisku, posiada bardzo dobre właściwości izolacyjne [6]. Tlenek cyrkonu jest materiałem biozgodnym, a jego barwa jest biała, dzięki czemu znalazł tak szerokie zastosowanie w stomatologii (uzupełnienia protetyczne) i ortopedii (implant stawu biodrowego) [5,6].…”

Section: Symulacja Obróbki Laserowej Zrounclassified

Precise laser machining of difficult to cut materials

Wyszyński¹

2015

Mechanik

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“…The oxides of metals such as Al, Ti, Zr, Nb and Ta satisfy all these properties to some degree [3][4][5]. Indeed, some of these metal oxides are used in medicine independently without a metal substrate, such as implant constructions from sapphire (a single-crystal modification of Al 2 O 3 ) [6,7].…”

Section: Introductionmentioning

confidence: 99%

The application of niobium and tantalum oxides for implant surface passivation

Стариков¹

2007

JBPC

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The corrosion of the surfaces of metallic implants is a very aggressive process, which can cause inflammation and deposition of metal in the surrounding live tissue. Prevention of corrosion and improvement of the functional characteristics of different coatings for application on implant surfaces is essential. Niobium and tantalum anodic oxides of optimal thickness have enabled the manufacture of a new generation of bioengineering products displaying minimal corrosion.

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Bioactivity and cytocompatibility of zirconia (ZrO2) films fabricated by cathodic arc deposition

Cited by 107 publications

References 33 publications

Biological Behavior of Osteoblast-like Cells on Titania and Zirconia Films Deposited by Cathodic Arc Deposition

Biological Behavior of Osteoblast-like Cells on Titania and Zirconia Films Deposited by Cathodic Arc Deposition

Precise laser machining of difficult to cut materials

The application of niobium and tantalum oxides for implant surface passivation

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