Bioactivity and osseointegration study of calcium phosphate ceramic of different chemical composition

Manjubala, I.; Sivakumar, M.; Sureshkumar, R.; Sastry, T. P.

doi:10.1002/jbm.10128.abs

Cited by 18 publications

(27 citation statements)

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“…22 Synthetic calcium phosphate ceramics are biocompatible, have bioactive properties and, thus, have been widely used, presenting good clinical and histologic results. 12,13,24 Their inorganic chemical constitution is similar to that of natural bone, which makes them promising bone substitutes in the orthopedic and maxillofacial fields, [25][26][27][28][29][30][31][32][33][34] acting as a framework for the implantation of osteoblasts and deposition of bone matrix, favoring the formation of bone trabeculae in the midst of the particles of material, because of the properties of osteoconduction. 26 The process of new bone formation begins at the periphery of the graft area, through the differentiation of undifferentiated mesenchymal cells into osteoblasts and their migration towards the biomaterial.…”

Section: Introductionmentioning

confidence: 99%

“…Hydroxyapatite (HA) and tricalcium phosphate (TCP) are widely used calcium phosphate ceramics. 12,16,24,26 These biomaterials are non-toxic 22,23,[25][26][27][28] and have excellent osteoconductive activity. They differ in their composition and in relation to their metabolism, presenting different times of degradation.…”

Section: Introductionmentioning

confidence: 99%

“…They differ in their composition and in relation to their metabolism, presenting different times of degradation. 28 HA has a biologically significant drawback which is its low solubility, which interferes with its degradation and replacement by new formed bone. 29 TCP is available in two forms 28,30 : -TCP and ß-TCP, which are produced at temperatures above or below 1125 • C, respectively.…”

Section: Introductionmentioning

confidence: 99%

“…28 HA has a biologically significant drawback which is its low solubility, which interferes with its degradation and replacement by new formed bone. 29 TCP is available in two forms 28,30 : -TCP and ß-TCP, which are produced at temperatures above or below 1125 • C, respectively. In contrast to -TCP, ß-TCP is thermodynamically stable 27,28 and biodegradades faster in a biologic environment and within a normal temperature range.…”

Section: Introductionmentioning

confidence: 99%

“…29 TCP is available in two forms 28,30 : -TCP and ß-TCP, which are produced at temperatures above or below 1125 • C, respectively. In contrast to -TCP, ß-TCP is thermodynamically stable 27,28 and biodegradades faster in a biologic environment and within a normal temperature range. 28,30 Highly porous TCP materials presente low volumetric stability after implantation, thus, these materials have been associated with other ceramics, such as HA, which can maintain its mechanical resistance until the resorption is achieved.…”

Section: Introductionmentioning

confidence: 99%

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Effects of methods of hydration of a biphasic ceramic graft on bone regeneration of extraction socket defects

Santos

Santana

Alves

et al. 2018

Journal of Periodontology

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Background Alveolar volumetric changes are inherent to the healing process after tooth extraction and filling of the extraction site with biomaterials can reduce these volumetric changes and provide a more favorable environment for the future prosthetic restoration with implants. Among the biomaterials available, biphasic ceramic compounds have shown promissing clinical results, however, histologic evaluation of bone tissue response to different hydration and incorporation methods are limited. The objective of this study was to comparatively evaluate in vivo the osteoconductive potential of the biphasic ceramic bone substitute (SBC) composed of beta‐tricalcium phosphate and hydroxyapatite after different hydration methodologies in rat extraction sockets. Methods Wistar rats (n = 20) were randomly distributed in two subgroups (G1, G2) according to the hydration methods used. After extraction of the right upper central incisor the alveoli were filled with SBC hydrated by two different methods. Group 1: biomaterial hydrated in blood; Group 2: biomaterial hydrated in physiologic saline. The animals were euthanized after 1 and 6 weeks for removal of the bone blocks containing the biomaterial and were submitted to histologic processing. Five‐μm‐thick demineralized sections of the samples were stained with hematoxylin and eosin (HE) and subjected to histomorphometric analysis. Results Bone formation was limited 7 days after the extraction procedure and increased in both groups between 7 and 42 days from surgery, demonstrating a time dependent increase of bone volume throughtout the experimental period (p < 0.05). Conclusions The hydration of SBC with saline significantly increased new bone formation and reduced connective tissue volume after 42 days demonstrating that hydration method may significantly influence bone healing in such defects, and, thus should be carefully performed.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Effects of methods of hydration of a biphasic ceramic graft on bone regeneration of extraction socket defects

Santos

Santana

Alves

et al. 2018

Journal of Periodontology

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Bioactivity tests of calcium phosphates with variant molar ratios of main components

Pluta

Sobczak-Kupiec

Poltorak

et al. 2018

J Biomedical Materials Res

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Calcium phosphates constitute attractive materials of biomedical applications. Among them particular attention is devoted to bioactive hydroxyapatite (HAp) and bioresorbable tricalcium phosphate (TCP) that possess ability to bind to living bones and can be used clinically as important bone substitutes. Notably, in vivo bone bioactivity can be predicted from apatite formation of bone immersed in SBF fluids. Thus, analyses of behavior of calcium phosphates immersed in various bio fluids are of great importance. Recently, stoichiometric HAp and TCP structures have been widely studied, whereas only limited number of publications have been devoted to analyses of nonstoichiometric calcium phosphates. Here, we report physicochemical analysis of natural and synthetic phosphates with variable Ca/P molar ratios. Subsequently attained structures were subjected to incubation in either artificial saliva or Ringer's fluids. Both pH and conductivity of such fluids were determined before and after incubation. Furthermore, the influence of the Ca/P values on such parameters was exemplified. Physicochemical analysis of received materials was performed by XRD and FT-IR characterization techniques. Their potential antibacterial activity and behavior in the presence of infectious microorganisms as Escherichia coli and Staphylococcus aureus was also evaluated. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 1941-1950, 2018.

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HA/TCP compounding of a porous CaP biomaterial improves bone formation and scaffold degradation—A long‐term histological study

et al. 2005

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In the present study, two biphasic calcium phosphate biomaterials (BCP) with HA/TCP ratios of 50/50 and 30/70 were obtained from a pure HA biomaterial. The biomaterials which showed the same three-dimensional geometry were implanted into corticocancellous costal defects of sheep. In the specimens of all three biomaterials, abundant bone formation, mineral dissolution from the biomaterial scaffolds, and active cellular resorption of the scaffolds was present after 6 and 12 months. Backscattered electron microscopy showed bone invasion into the pores of the scaffolds and micromechanical interlocking at the bone/biomaterial interface without intervening soft tissue. The pattern of bone formation and scaffold resorption was different for cortical and cancellous bone. No time-based effect, however, was observed. Overall, the BCP biomaterials had formed significantly more bone than the HA biomaterial. Also, scaffold resorption, which was followed by a replacement with newly formed bone, was significantly higher in the BCP biomaterials. Although no significant differences were observed between both BCP biomaterials, the present study had confirmed the assumption that HA/TCP compounding was suitable to improve bone formation and scaffold resorption in the investigated biomaterials and at the same time maintain the osteoconductive properties of the scaffolds.

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Bioactivity and osseointegration study of calcium phosphate ceramic of different chemical composition

Cited by 18 publications

References 0 publications

Effects of methods of hydration of a biphasic ceramic graft on bone regeneration of extraction socket defects

Effects of methods of hydration of a biphasic ceramic graft on bone regeneration of extraction socket defects

Bioactivity tests of calcium phosphates with variant molar ratios of main components

HA/TCP compounding of a porous CaP biomaterial improves bone formation and scaffold degradation—A long‐term histological study

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