Bioactivity-guided isolation of anti-hepatitis B virus active sesquiterpenoids from the traditional Chinese medicine: Rhizomes of Cyperus rotundus

Xu, Hongbo; Ma, Yun‐Bao; Huang, Xiaoyan; Geng, Chang‐An; Wang, Hao; Zhao, Yong; Yang, Tonghua; Chen, Xing‐Long; Yang, Cheng-Ao; Zhang, Xuemei

doi:10.1016/j.jep.2015.05.040

Cited by 60 publications

(16 citation statements)

References 56 publications

(54 reference statements)

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“…Naturally occurring oplopanane sesquiterpenoids are rarely reported [ 16 , 17 ]. Literature searching showed that there were no more than 20 such type sesquiterpenoids reported up to now, distributed among the families of Alismataceae [ 16 , 17 ], Araliaceae [ 18 ], Araceae [ 19 ], Asteraceae [ 20 ], Chloranthaceae [ 21 ], Cyperaceae [ 22 ], Magnoliaceae [ 23 ], Meliaceae [ 24 ], Schisandraceae [ 25 ], Salicaceae [ 26 ], and Zingiberaceae [ 27 ]. In this study, six oplopananes ( 1 – 6 ), including four new ( 1 – 4 ) and one 3,5- seco -oplopanane ( 6 ), were discovered from the rhizomes of H. occulta .…”

Section: Resultsmentioning

confidence: 99%

Sesquiterpenoids from the Rhizomes of Homalomena occulta

Yang

Zhao

Shi

2016

Nat. Prod. Bioprospect.

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Naturally occurring oplopanane sesquiterpenoids are rarely reported. A phytochemical investigation on the rhizomes of Homalomena occulta (Lours) has resulted in the discovery of six oplopanane sesquiterpenoids (1–6), including four new (1–4) and one 3,5-seco-oplopanane (6), together with three previously reported sesquiterpenoids (7−9). In addition three new oplopananes (2a–4a) were also obtained by chemical transformation. All structures of these sesquiterpenoids were established based on the comprehensive spectroscopic analyses, including NMR, MS, and IR, and comparing with the literatures.Graphical AbstractElectronic supplementary materialThe online version of this article (doi:10.1007/s13659-016-0104-8) contains supplementary material, which is available to authorized users.

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Section: Resultsmentioning

confidence: 99%

Sesquiterpenoids from the Rhizomes of Homalomena occulta

Yang

Zhao

Shi

2016

Nat. Prod. Bioprospect.

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“…[28] Scientists have reported that rhizomes and tubers of C. rotundus possess antidiarrheal, antioxidant, anti-inflammatory, anti-mutagenic, antiperiodic, anticonvulsant, anti-saturative, anti-pyretic, antifungal, antidiabetic, antimalarial, anti lipidemic, anti-bacterial, antiviral, anti-tumour, cardio protective and wound-healing properties. [29] Recently, Xu et al, [30] revealed the anti-hepatitis B virus as bioactivity of C.rotundus rhizomes. In addition to, the work of Zhou et al, [31] whom purified two new cycloartane glycosides from rhizomes of C. rotundus and evaluated their anti-depressant activity in mice models.…”

Section: World Journal Of Pharmaceutical Researchmentioning

confidence: 99%

Efficacy of Cyperus Rotundus Rhizomes-Tubers Extracts Against Protoscoleces of Echinococcus Granulosus

Shnawa¹

2017

WJPR

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“…Thirty-seven sesquiterpenoids were isolated from the fraction of C. rotundus using liquid chromatography-mass spectrometry (LC-MS). Six of those sesquiterpenoids may contribute to the anti-HBV activity of C. rotundus (32). Plants of the genus Swertia (Gentianaceae), annual or perennial herbs, are thought to have hepatoprotective activity but whether they contained anti-HBV compounds was unclear.…”

Section: Cells (19)mentioning

confidence: 99%