Bioactivity guided isolation of antiinflammatory, analgesic, and antipyretic constituents from the leaves of Pedilanthus tithymaloides (L.)

Ghosh, Soma; Chattopadhyay, Debprasad; Mandal, Anurup; Kaity, Sudipta; Samanta, Amalesh

doi:10.1007/s00044-012-0449-4

Cited by 22 publications

(32 citation statements)

References 38 publications

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“…These findings suggested the central antinociceptive activity of TMEF. It is known that nociception takes place in two phases; the early phase pain (0–5 min) is induced by chemical stimulation of the C‐fibers, while the late phase pain (15–30 min) is caused by the production of inflammatory mediators like prostaglandins, histamine, and bradykinin [Ghosh et al, ]. In this study, the late phase response (after 120 min) demonstrated that the anti‐nociceptive activity of TMEF is due to the inhibition of inflammatory mediators.…”

Section: Discussionsupporting

confidence: 49%

“…These writhes are correlated to the elevation in prostaglandin levels [Deraedt et al, ]. Therefore, the analgesic activity of TMEF is possibly due to the inhibition of the cyclooxygenase enzyme (COX‐2), with subsequent inhibition of prostaglandins [Ghosh et al, ]. The effect of TMEF on central pain was evaluated using the hot‐plate test, a model of supraspinal reflex, which is considered as an important tool for the evaluation of central anti‐nociceptive activity by thermal stimuli [Yaksh and Rudy, ; Ghosh et al, ].…”

Section: Discussionmentioning

confidence: 99%

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Anti‐Inflammatory and Analgesic Activities of Terminalia Muelleri Benth. (Combretaceae)

Fahmy

Al‐Sayed

Abdel-Daim

et al. 2017

Drug Development Research

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Preclinical Research The anti-inflammatory and analgesic activities of a polyphenol-rich fraction (TMEF) obtained from Terminalia muelleri Benth. were measured. The analgesic activity of TMEF was tested using acetic acid-induced writhing and hot plate models in mice. The anti-inflammatory activity was assessed using carrageenan-induced paw edema model by measuring PGE , TNF-α, IL-1β, and IL-6 plasma levels as well as the paw thickness. TMEF was tested at doses of 100, 200, and 400 mg/kg p.o. and diclofenac sodium was used as a standard (100 mg/kg) in all experiments. The group treated with 400 mg/kg of TMEF showed a greater inhibition in the number of writhes (by 63%) than the standard-treated group (61%). Pretreatment with TMEF increased the analgesic effect in hot plate test in a dose-dependent manner with a maximum effect after 120 min. TMEF pretreatment alos reduced the edema thickness by 48, 53, and 62% at the tested doses, respectively. TMEF administration inhibited the carrageenan-induced elevations in PGE (by 34, 43, and 47%), TNF-α (18, 28, and 41%), IL-1β (14, 22, and 29%), and IL-6 (26, 31, and 46%). Four phenolic compounds were isolated from Terminalia muelleri for the first time. Drug Dev Res 78 : 146-154, 2017. © 2017 Wiley Periodicals, Inc.

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Section: Discussionsupporting

confidence: 49%

Section: Discussionmentioning

confidence: 99%

Anti‐Inflammatory and Analgesic Activities of Terminalia Muelleri Benth. (Combretaceae)

Fahmy

Al‐Sayed

Abdel-Daim

et al. 2017

Drug Development Research

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“…and the isolated compound ASE-1 (50 and 100 mg/ kg, b.w.). The animals were observed continuously in the first 2-24 h for toxic symptoms and up to 72 h for mortality (Litchfield and Wilcoxon, 1949;Ghosh et al, 2013).…”

Section: Experimental Animalsmentioning

confidence: 99%

“…The animals of the test groups were orally administered with 10 and 20 mg/kg of ASE-1, while indomethacin (10 mg/kg) or CMC (0.3 %) was administered to the drug or vehicle control group, respectively, 30 min prior to the sub-plantar injection of carrageenan (0.02 ml) in normal saline into the right hind paw of each mouse (Ghosh et al, 2013). Paw volume was measured with a plethysmometer immediately and thereafter at hourly intervals till 5 h after carrageenan injection.…”

Section: Evaluation Of Anti-inflammatory Activitymentioning

confidence: 99%

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Bioassay directed isolation of a novel anti-inflammatory cerebroside from the leaves of Aerva sanguinolenta

Mandal

Ojha²,

Lalee

et al. 2014

Med Chem Res

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This paper attempts to evaluate the antiinflammatory potential and the possible mechanism of action of the leaf extracts and isolated compound(s) of Aerva sanguinolenta (Amaranthaceae), traditionally used in ailments related to inflammation. The anti-inflammatory activity of ethanol extract (ASE) was evaluated by acute, subacute and chronic models of inflammation, while a new cerebroside ('trans', ASE-1), isolated from the bioactive ASE and characterized spectroscopically, was tested by carrageenan-induced mouse paw oedema and protein exudation model. To understand the underlying mechanism, we measured the release of pro-inflammatory mediators such as nitric oxide (NO) and prostaglandin (PG)E2, along with the cytokines like tumour necrosis factor (TNF)-a, and interleukins(IL)-1b, IL-6 and IL-12 from lipopolysaccharide (LPS)-stimulated peritoneal macrophages. The results revealed that ASE at 400 mg/kg caused significant reduction of rat paw oedema, granuloma and exudative inflammation, while the inhibition of mouse paw oedema and exudative inflammation by ASE-1 (20 mg/kg) was comparable to that of the standard drug indomethacin (10 mg/kg). Interestingly, both ASE and ASE-1 showed significant inhibition of the expressions of iNOS2 and COX-2, and the down-regulation of the expressions of IL-1b, IL-6, IL-12 and TNF-a, in LPS-stimulated macrophages, via the inhibition of COX-2-mediated PGE2 release. Thus, our results validated the traditional use of A. sanguinolenta leaves in inflammation management.

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Flavonoids and Triterpenoids Isolated From the Ethyl Acetate Extract of M. quadrangulata Leaves

de Aguilar,

Veríssimo Morais Quintão,

Camargo

et al. 2024

Chemistry & Biodiversity

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The new flavonoid 4’‐O‐methylepigallocatechin 5‐O‐β‐D‐glucopyranoside (1), along with four known triterpenes (2‐4), a steroid (6), and a flavonoid (7) were isolated from the ethyl acetate extract of Maytenus quadrangulata leaves. The chemical structures of the isolated compounds were determined through analysis of 1D NMR (1H and 13C) spectroscopic data, in addition to 2D NMR and spectrometric (MS) data for compound 1. This is the first report of the isolation of compounds 3‐O‐β‐D‐glucosyl‐β‐sitosterol (6) and 4’‐O‐methylepigallocatechin (7) from this species. Compounds 1 and 7 were evaluated against the bacteria Staphylococcus aureus and Klebsiella pneumoniae, but neither exhibited activity even at the highest concentration tested.

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Bioactivity guided isolation of antiinflammatory, analgesic, and antipyretic constituents from the leaves of Pedilanthus tithymaloides (L.)

Cited by 22 publications

References 38 publications

Anti‐Inflammatory and Analgesic Activities of Terminalia Muelleri Benth. (Combretaceae)

Anti‐Inflammatory and Analgesic Activities of Terminalia Muelleri Benth. (Combretaceae)

Bioassay directed isolation of a novel anti-inflammatory cerebroside from the leaves of Aerva sanguinolenta

Flavonoids and Triterpenoids Isolated From the Ethyl Acetate Extract of M. quadrangulata Leaves

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