Bioactivity-guided isolation of cytotoxic secondary metabolites from the roots of Glycyrrhiza glabra and elucidation of their mechanisms of action

Glycyrrhiza Genus: Enlightening Phytochemical Components for Pharmacological and Health‐Promoting Abilities

“…In addition, Jo et al [ 121 ] also concluded that Glycyrrhiza glabra L. roots exhibited preventive activity against breast cancer. Glycyrrhiza glabra L. extract also demonstrated cytotoxicity against hepatocellular, breast, and colorectal cancer cell lines with IC 50 values in the range of 5.6 to 33.6 μ g/mL [ 122 ]. It was also revealed that the cytotoxic activity of the methanol extract of licorice roots against immortal human keratinocyte, lung adenocarcinoma, and liver carcinoma cell lines varied depending on geographical origin [ 123 ].…”

Valorisation of liquorice (Glycyrrhiza) roots: antimicrobial activity and cytotoxicity of prenylated (iso)flavonoids and chalcones from liquorice spent (G. glabra, G. inflata, and G. uralensis)

“…51 Previously, it was shown that G. glabra solvent-based root extracts were cytotoxic between 7.4-34 µg mL −1 in colorectal cancer cells. 52 Additionally, Jo et al evaluated cytotoxicity of…”

“…Our observed cytotoxicity is in line with reported cytotoxicity of glab against other cell lines. 52,55 Cytotoxic mode of action of structural similar compounds 4′-OH-methylglabridin and glabrene was related to changes in cell cycle signalling pathways, ultimately leading to apoptotic cell death via different mechanisms. 52,56 It could be hypothesized that, due to structural similarity, glab shows a similar cytotoxic mode of action.…”

“…52,55 Cytotoxic mode of action of structural similar compounds 4′-OH-methylglabridin and glabrene was related to changes in cell cycle signalling pathways, ultimately leading to apoptotic cell death via different mechanisms. 52,56 It could be hypothesized that, due to structural similarity, glab shows a similar cytotoxic mode of action. Our observed cytotoxicity of licoA at 12.5 µg mL −1 is in line with previously reported cytotoxicity in different cancer cell lines.…”

Three New Compounds, Licopyranol A–C, Together with Eighteen Known Compounds Isolated from Glycyrrhiza glabra L. and Their Antitumor Activities

“…Flavonoids of licorice showed important inhibitory effects on colorectal, breast, prostate, liver, stomach, bladder, and lung cancers [ 12 ]. Furthermore, the isolated compounds from the methanolic and ethyl acetate extract of G. glabra were found to show significant cytotoxic and anticancer properties [ 13 , 14 ].…”