Bioactivity of Aqueous Extract of Pulp ofCrysophyllum albidium(G. Don-Holl.) on Isoproterenol Treated Albino Rats

Abstract

Cardiovascular disorder is one of the causes of death globally. Quite a number of medicinal plants have been demonstrated to possess and exhibit beneficial effects on cardiovascular system throuhg their antioxidant properties. The study investigated the in vivo antioxidant properties of aqueous C. albidium pulp extract on isoproterenol-induced cardiotoxicity in albino rats. Cardiotoxicity was induced in rats by subcutaneous injection of ISO (85 mg/kg bwt) into adult albino rats and treated with the extract (100 and 200 mg/kg bwt). The levels of nitrite, lipid peroxidation, reduced glutathione total protein and activities of glutathione peroxidase, catalase and superoxide dismutase were evaluated using standard methods. The concentration of total protein was also determined. Administration of ISO (85 mg/kg body weight) caused significant (p < 0.05) reduction in the antioxidant status of animals. The enzymatic and non-enzymatic antioxidants perturbed by the administration of ISO were restored in the C. albidium treated rats. The study concludes that the aqueous extract of C. albidum pulp protected against Isoproterenol-induced cardiotoxicity in adult male Albino rats.

Studies on Phytochemicals and Bioactivities of Methanolic Extract of Leucaena leucocephala (Lam.) de Wit Fruit Pods

“…The antioxidants act through the transfer of hydrogen atoms and by transfer of electrons or chelating of metals [29,30]. The LLFPME showed strong DPPH scavenging activity, ferric reducing antioxidant power and total antioxidant capacity; which compared favourably with the standard drugs used and are consistent with earlier studies [28,29,31,32]. Olarewaju et al [32] reported that total antioxidant capacity of a vegetable is primarily due to the presence of flavonoids and related polyphenols while ferric reducing antioxidant power of selected plant leaves were dose dependent.…”

“…Olarewaju et al [32] reported that total antioxidant capacity of a vegetable is primarily due to the presence of flavonoids and related polyphenols while ferric reducing antioxidant power of selected plant leaves were dose dependent. Fajobi et al [29] and Morakinyo et al [31] also reported dose dependent activities of Pterocarpus mildbraedii and Aframomum melegueta leaves respectively on DPPH and H2O2 radicals, TAC and FRAP.…”

Comparative Hypolipidemic Evaluation of Aframomum Melegueta Seeds and Moringa Oleifera Leaves

“…The significance of this study is also centered on the need to establish an easily accessible natural remedy for the prophylaxis of several cardiovascular diseases. Since recent studies on Moringa oleifera leaves and Aframomum melegueta seeds have shown significant lipid lowering effect [3,4], there is an urgent need to compare the lipid lowering properties of both crude drugs and in turn establish a possible additive, synergistic or antagonistic effect when both crude drugs are used simultaneously.…”